WBGene00004921 | SMap | S_parent | Sequence | F31E8 |
| Identity | Version | 1 |
| | Name | CGC_name | snt-1 | Person_evidence | WBPerson508 |
| | | Sequence_name | F31E8.2 |
| | | Molecular_name | F31E8.2a |
| | | | F31E8.2a.1 |
| | | | CE02711 |
| | | | F31E8.2b |
| | | | CE28229 |
| | | | F31E8.2b.1 |
| | | Other_name | ric-2 |
| | | | unc-121 |
| | | | syt1 | Accession_evidence | EMBL | AJ303369 |
| | | | syt-1 |
| | | | CELE_F31E8.2 | Accession_evidence | NDB | BX284602 |
| | | Public_name | snt-1 |
| | DB_info | Database | AceView | gene | 2H105 |
| | | | WormQTL | gene | WBGene00004921 |
| | | | WormFlux | gene | WBGene00004921 |
| | | | NDB | locus_tag | CELE_F31E8.2 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00004921|UniProtKB=P34693 |
| | | | | family | PTHR10024 |
| | | | NCBI | gene | 174120 |
| | | | RefSeq | protein | NM_062993.9 |
| | | | | | NM_001026958.6 |
| | | | SwissProt | UniProtAcc | P34693 |
| | | | TrEMBL | UniProtAcc | Q95QH7 |
| | | | UniProt_GCRP | UniProtAcc | P34693 |
| | | | OMIM | gene | 600104 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | snt |
| | Allele (91) |
| | Legacy_information | [Rand JB] uncoordinated, slight shrinker, small, slow-growing, resistant to cholinesterase inhibitors. |
| | | [C.elegansII] md125 : (pka ric-2) uncoordinated, slight shrinker, small, slow-growing, resistant to cholinesterase inhibitors; some pumping and defecation defects. OA2: ad596 (pka unc-121, Unc, worse when starved; ME2), n2665. Cloned: encodes synaptotagmin (54% identity to mammalian synaptotagmin) [Nonet et al. 1993; Nguyen et al. 1995; NM; RM] |
| | Complementation_data | [Rand JB] complements unc-104(e1265), egl-27(n170), let-263(mn240) |
| | Strain (13) |
| | RNASeq_FPKM (74) |
| | GO_annotation (41) |
| | Ortholog (62) |
| | Paralog | WBGene00004922 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004923 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004924 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00011682 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004926 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004925 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004316 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00006306 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00020861 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | snt-1 encodes two proteins, SNT-1A and SNT-1B, orthologous to synaptotagmin; SNT-1 is required for synaptic vesicle exocytosis and neurotransmitter release as well as for synaptic vesicle recycling via clathrin-mediated endocytosis; accordingly, snt-1 activity is required for a variety of behaviors including pharyngeal pumping, locomotion, and defecation; SNT-1A and SNT-1B isoforms are expressed in neurons, with SNT-1A typically expressed at higher levels, and in a greater number of neurons, than SNT-1B; in addition, SNT-1B is exclusively expressed in the excretory duct cell and a group of tail neurons including DVB, a GABAergic neuron required for defecation. | Paper_evidence | WBPaper00001709 |
| | | | | | WBPaper00001750 |
| | | | | | WBPaper00002316 |
| | | | | | WBPaper00029143 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 16 Apr 2007 00:00:00 |
| | | Automated_description | Enables calcium ion sensor activity and calcium-dependent phospholipid binding activity. Involved in several processes, including defecation; regulation of pharyngeal pumping; and synaptic vesicle endocytosis. Located in synaptic vesicle. Expressed in several structures, including excretory gland cell; gonad; nervous system; pharyngeal gland cell; and rectal gland cell. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 7. Is an ortholog of human SYT1 (synaptotagmin 1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0110659 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11510) |
| | | DOID:3635 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11510) |
| Molecular_info | Corresponding_CDS | F31E8.2a |
| | | F31E8.2b |
| | Corresponding_transcript | F31E8.2a.1 |
| | | F31E8.2b.1 |
| | Other_sequence (64) |
| | Associated_feature (15) |
| Experimental_info | RNAi_result | WBRNAi00089992 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00046026 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090310 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00092941 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00112395 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00027612 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00076365 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00022346 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089812 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090151 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (11) |
| | Drives_construct | WBCnstr00003269 |
| | | WBCnstr00005350 |
| | | WBCnstr00005351 |
| | | WBCnstr00009600 |
| | | WBCnstr00009601 |
| | | WBCnstr00017690 |
| | | WBCnstr00035321 |
| | | WBCnstr00038765 |
| | | WBCnstr00038766 |
| | Construct_product | WBCnstr00001653 |
| | | WBCnstr00005350 |
| | | WBCnstr00005351 |
| | | WBCnstr00017690 |
| | | WBCnstr00019062 |
| | | WBCnstr00021442 |
| | | WBCnstr00035321 |
| | | WBCnstr00038765 |
| | | WBCnstr00038766 |
| | Antibody | WBAntibody00000070 |
| | | WBAntibody00000152 |
| | | WBAntibody00000347 |
| | | WBAntibody00000730 |
| | | WBAntibody00000906 |
| | | WBAntibody00001655 |
| | Microarray_results (31) |
| | Expression_cluster | WBPaper00024970:GABAergic_neuron_specific |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00035211:age-1_vs_age-1_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037682:sma-2_sma-4_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_embryo_enriched |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_embryo_enriched |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_embryo_enriched |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:BAG-neuron_embryo_enriched |
| | | WBPaper00037950:coelomocytes_embryo_enriched |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_CoreEnriched |
| | | WBPaper00037950:dopaminergic-neurons_embryo_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00044037:eat-2_upregulated |
| | | WBPaper00044656:tatn-1(qd182)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049001:EVN_enriched |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050231:male_enriched |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster4 |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055648:male-vas-deferens_expressed |
| | | WBPaper00055969:electromagnetic-field_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056284:ints-1(RNAi)_downregulated |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057041:spc-1(cas971)_downregulated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058711:wdr-5(ok1417)_upregulated |
| | | WBPaper00058948:npr-8(ok1439)_downregulated_OP50 |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059728:5ug_cholesterol_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ADF |
| | | WBPaper00061340:AIB |
| | | WBPaper00061340:AIY |
| | | WBPaper00061340:AIZ |
| | | WBPaper00061340:ALA |
| | | WBPaper00061340:ASH |
| | | WBPaper00061340:AUA |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:AVH |
| | | WBPaper00061340:AVL |
| | | WBPaper00061340:BAG |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:IL1 |
| | | WBPaper00061340:RIA |
| | | WBPaper00061340:RIM |
| | | WBPaper00061340:SMD |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:kin-29_2839-unc-9_3883 |
| | | WBPaper00061527:unc-13_19769-unc-13_278 |
| | | WBPaper00061651:AIZ_enriched |
| | | WBPaper00061651:AS_enriched |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:DB01_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:DVB_enriched |
| | | WBPaper00061651:HSN_enriched |
| | | WBPaper00061651:M5_enriched |
| | | WBPaper00061651:MC_enriched |
| | | WBPaper00061651:NSM_enriched |
| | | WBPaper00061651:PVC_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00061651:VA_enriched |
| | | WBPaper00061651:VB_enriched |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:hsf-1(RNAi)_downregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062520:qui-1(db104)_upregulated |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064871:hypoxia_downregulated_F1 |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065841:68_1 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | cgc4489_group_18 |
| | | cgc4489_male_enriched_neuronal_genes |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025032:cluster_155 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_A_Class |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00030985:Enterococcus_faecalis_downregulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00032948:StarveUp2 |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00036130:mir-243_up_regulated |
| | | WBPaper00040184:hcf-1up_sir-2.1up_daf-2up |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040876:mir-35_downregulated |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_EtBr-exposed_51h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_3h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-exposed_3h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00042258:DA1877_upregulated_GravidAdult |
| | | WBPaper00042548:miRISC_enriched |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00045960:L1-L4-lethargus_upregulated |
| | | WBPaper00045960:L4-lethargus_upregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc6390]:Cluster_A |
| | Interaction (77) |
| Map_info | Map | II | Position | 0.115793 | Error | 0.000262 |
| | Well_ordered |
| | Positive | Positive_clone | F31E8 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | F58D4 |
| | | | K10B7 |
| | Mapping_data | 2_point | 6025 |
| | | | 6167 |
| | | Multi_point | 2072 |
| | | | 2073 |
| | | | 2422 |
| | | | 2423 |
| | | | 2424 |
| | | Pos_neg_data (18) |
| Reference (115) |
| Remark | [Rand JB] structural gene for synaptotagmin (cosmid hybridization by Nonet M). Null alleles viable. 14 additional md alleles exist. |
| Method | Gene |