rab-11.1 encodes a small GTPase homologous to the Rab GTPases that function in endocytosis, membrane fusion, and vesicular trafficking events; RAB-11.1 activity is required for completion of the final stages of cytokinesis during early embryogenesis and for efficient uptake of yolk proteins during oocyte development; RAB-11.1 is also required for normal peripheral localization of nuclei in the synctial germ cell in the ovary and for regulated secretion of CAV-1-containing cortical granules following fertilization; RAB-11.1 localizes to recycling endosomes and to cortical granules.
Predicted to enable GTP binding activity and GTPase activity. Involved in several processes, including eggshell formation; membrane addition at site of mitotic cytokinesis; and vesicle-mediated transport. Located in Golgi trans cisterna membrane; cortical granule; and recycling endosome. Expressed in gonad. Is an ortholog of human RAB11A (RAB11A, member RAS oncogene family).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.