| WBGene00003003 | SMap | S_parent | Sequence | T25C12 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | lin-14 | Person_evidence | WBPerson261 |
| | | Sequence_name | T25C12.1 |
| | | Molecular_name | T25C12.1a |
| | | | T25C12.1a.1 |
| | | | CE43285 |
| | | | T25C12.1b |
| | | | CE03734 |
| | | | T25C12.1b.1 |
| | | Other_name | CELE_T25C12.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | lin-14 |
| | DB_info | Database | AceView | gene | XM103 |
| | | | WormQTL | gene | WBGene00003003 |
| | | | WormFlux | gene | WBGene00003003 |
| | | | NDB | locus_tag | CELE_T25C12.1 |
| | | | NCBI | gene | 181337 |
| | | | RefSeq | protein | NM_077515.5 |
| | | | | | NM_077516.7 |
| | | | SwissProt | UniProtAcc | Q21446 |
| | | | TREEFAM | TREEFAM_ID | TF316913 |
| | | | UniProt_GCRP | UniProtAcc | Q21446 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lin |
| | Reference_allele | WBVar00089301 |
| | | WBVar00089587 |
| | Allele (337) |
| | Legacy_information (3) |
| | Strain (20) |
| | RNASeq_FPKM (74) |
| | GO_annotation (16) |
| | Ortholog (28) |
| | Structured_description | Concise_description | lin-14 encodes a novel protein whose activity is required for specifying the division timings of a specific group of cells during postembryonic development; lin-14 loss-of-function mutations result in the premature appearance of later larval lineages, while gain-of-function mutations result in reiteration of L1 larval stages lineages; in addition, lin-14 acts as a positive regulator of AVM, PVM, and FLP touch cell development; in regulating developmental timing, lin-14 acts, in part, by positively regulating the activity of lin-28, which encodes a cytoplasmic protein also required for proper developmental timing; at hatching, LIN-14 is detected in the nuclei of blast cells and neurons; later, from the late L1 to adult stages, LIN-14 levels are negatively regulated by translational repression mediated by lin-4, a 22-nt small temporal RNA (stRNA) that is complementary to sequences in the lin-14 3' UTR. | Paper_evidence | WBPaper00000620 |
| | | | | | WBPaper00001137 |
| | | | | | WBPaper00001468 |
| | | | | | WBPaper00001829 |
| | | | | | WBPaper00001848 |
| | | | | | WBPaper00003931 |
| | | | | | WBPaper00005159 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 02 Sep 2005 00:00:00 |
| | | Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and single-stranded DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of cell fate specification; and regulation of nematode larval development, heterochronic. Located in condensed nuclear chromosome. Expressed in several structures, including QL; QR; neurons; oocyte; and somatic nervous system. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | T25C12.1a |
| | | T25C12.1b |
| | Corresponding_CDS_history | T25C12.1a:wp196 |
| | Corresponding_transcript | T25C12.1a.1 |
| | | T25C12.1b.1 |
| | Other_sequence (11) |
| | Associated_feature | WBsf648548 |
| | | WBsf663342 |
| | | WBsf663343 |
| | | WBsf663344 |
| | | WBsf663345 |
| | | WBsf663346 |
| | | WBsf663347 |
| | | WBsf663348 |
| | | WBsf663349 |
| | | WBsf663350 |
| | | WBsf663351 |
| | | WBsf663352 |
| | | WBsf663353 |
| | | WBsf663354 |
| | | WBsf663355 |
| | | WBsf663356 |
| | | WBsf663357 |
| | | WBsf663358 |
| | | WBsf663359 |
| | | WBsf718702 |
| | | WBsf982235 |
| | | WBsf1007004 |
| | | WBsf1007005 |
| | | WBsf1007006 |
| | | WBsf1007007 |
| | | WBsf1007008 |
| | | WBsf1007009 |
| | | WBsf1007010 |
| | | WBsf1007011 |
| | | WBsf1007012 |
| | | WBsf1007013 |
| | | WBsf1007014 |
| | | WBsf1007015 |
| | | WBsf1007016 |
| | | WBsf1007017 |
| | | WBsf1007018 |
| | | WBsf1007019 |
| | | WBsf1007020 |
| | | WBsf1007021 |
| | | WBsf1007022 |
| | | WBsf1007023 |
| | | WBsf1023877 |
| | | WBsf1023878 |
| | | WBsf1023879 |
| | | WBsf1023880 |
| | | WBsf1023881 |
| | | WBsf1023882 |
| | | WBsf1023883 |
| | | WBsf1023884 |
| | | WBsf1023885 |
| | | WBsf1023886 |
| | | WBsf1023887 |
| | | WBsf1023888 |
| | | WBsf236380 |
| | | WBsf919695 |
| | Transcription_factor | WBTranscriptionFactor000395 |
| Experimental_info | RNAi_result (17) |
| | Expr_pattern (13) |
| | Drives_construct | WBCnstr00000926 |
| | | WBCnstr00007336 |
| | | WBCnstr00007627 |
| | | WBCnstr00015030 |
| | | WBCnstr00015050 |
| | | WBCnstr00015780 |
| | | WBCnstr00015781 |
| | | WBCnstr00036292 |
| | Construct_product | WBCnstr00000967 |
| | | WBCnstr00007627 |
| | | WBCnstr00019563 |
| | | WBCnstr00019564 |
| | | WBCnstr00021119 |
| | | WBCnstr00021910 |
| | | WBCnstr00036292 |
| | Regulate_expr_cluster | WBPaper00026952:class_A |
| | | WBPaper00026952:class_B |
| | | WBPaper00026952:class_C |
| | | WBPaper00026952:class_D |
| | | WBPaper00026952:class_E |
| | | WBPaper00026952:class_F |
| | | WBPaper00026952:class_G |
| | | WBPaper00026952:class_H |
| | Antibody | WBAntibody00000046 |
| | | WBAntibody00000337 |
| | | WBAntibody00000338 |
| | | WBAntibody00001031 |
| | | WBAntibody00001569 |
| | | WBAntibody00001873 |
| | Microarray_results (33) |
| | Expression_cluster | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040221:DAF-12_target_ALF9 |
| | | WBPaper00042194:nhr-114(RNAi)_downregulated |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00042561:smg-2(RNAi)_downregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045316:prg-1_upregulated_L2 |
| | | WBPaper00045390:tunicamycin_downregulated |
| | | WBPaper00045390:ubc-9(RNAi)_downregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049217:TCER-1_downregulated |
| | | WBPaper00049377:MWCNT_upregulated |
| | | WBPaper00049498:npr-1(ur89)_regulated_4 |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00050332:skn-1(RNAi)_downregulated |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050412:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:intestine_enriched |
| | | WBPaper00051404:alg-1(gk214)_upregulated |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:stavudine_72h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053771:up_at_dpy-7(e88) |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055827:daf-2(e1370)_downregulated |
| | | WBPaper00055827:pfd-6(gk493446)_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056617:adr-1(gv6)_upregulated_embryo_protein |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058691:set-2(bn129)_upregulated |
| | | WBPaper00058691:WDR-5.1_interacting_protein |
| | | WBPaper00058711:paraquat_downregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059203:CAR-1_interacting |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00060911:prx-5(RNAi)_upregulated_mRNA |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061081:E.faecalis_upregulated_N2 |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061340:I5 |
| | | WBPaper00061340:XXX |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:HDA-1_interacting_protein |
| | | WBPaper00061527:tub-2_4713-daf-2_5288 |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062354:H.zoospora_6h_regulated |
| | | WBPaper00064005:starvation_downregulated_aptf-1(gk794)_protein |
| | | WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064055:trl-1(cas1077)_upregulated_non-starved |
| | | WBPaper00064055:trl-1(cas1077)_upregulated_starved |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064156:lbp-3(overexpress)_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064871:hypoxia_downregulated_F2 |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4489_group_22 |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00027111:rrf-1(pk1417)_upregulated |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00040876:mir-35_downregulated |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00045294:0.1uM_DBAA_downregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00047070:N2_UV_upregulated |
| | | WBPaper00048989:N2_allantoin_downregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00051304:CEH-23_repressed |
| | | WBPaper00056330:mrps-5(RNAi)_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | Interaction (256) |
| | WBProcess | WBbiopr:00000031 |
| | | WBbiopr:00000057 |
| | | WBbiopr:00000083 |
| Map_info | Map | X | Position | 3.78431 | Error | 0.060767 |
| | Well_ordered |
| | Positive | Inside_rearr | nDf19 |
| | | | yDp8 |
| | | | yDp10 |
| | | Positive_clone | PPE4 |
| | | | T25C12 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 251 |
| | | | 492 |
| | | | 636 |
| | | | 637 |
| | | | 688 |
| | | | 3648 |
| | | | 3652 |
| | | Multi_point (22) |
| | | Pos_neg_data | 3918 |
| | | | 3920 |
| | | | 654 |
| | | | 668 |
| | | | 3155 |
| | | | 294 |
| | | | 1831 |
| | | | 8427 |
| Reference (365) |
| Method | Gene |
