WormBase Tree Display for Gene: WBGene00015574

WBGene00015574 SMap: S_parent: Sequence: C07G3
  Identity: Version: 2
    Name: CGC_name: irg-1 Person_evidence: WBPerson3965
      Sequence_name: C07G3.2
      Molecular_name: C07G3.2
        C07G3.2.1
        CE07993
      Other_name: CELE_C07G3.2 Accession_evidence: NDB BX284605
      Public_name: irg-1
    DB_info: Database: AceView gene 5D999
        WormQTL gene WBGene00015574
        WormFlux gene WBGene00015574
        NDB locus_tag CELE_C07G3.2
        NCBI gene 182379
        RefSeq protein NM_071582.5
        TREEFAM TREEFAM_ID TF316991
        TrEMBL UniProtAcc O16327
        UniProt_GCRP UniProtAcc O16327
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:56 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 13 Jul 2009 13:51:47 WBPerson9133 Name_change: CGC_name: irg-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: irg
    Allele: WBVar01986405
      WBVar01499528
      WBVar01499167
      WBVar00275780
      WBVar01499740
      WBVar02052507
      WBVar01500129
      WBVar01615940
      WBVar01615941
      WBVar00256408
      WBVar01615942
      WBVar01615943
      WBVar01615944
      WBVar02123282
      WBVar00454176
      WBVar00454177
      WBVar00454178
      WBVar00454179
      WBVar00264192
      WBVar00454180
      WBVar00206477
      WBVar00206478
      WBVar00206479
      WBVar02124044
      WBVar02121470
      WBVar01499483
      WBVar01498943
      WBVar01498944
      WBVar01499496
      WBVar01499316
      WBVar00999445
      WBVar00999446
      WBVar00999447
      WBVar00999448
      WBVar00999449
      WBVar00999450
      WBVar01500066
    RNASeq_FPKM (74)
    GO_annotation: 00027834
      00027835
      00105960
      00105967
      00105968
    Ortholog (32)
    Paralog: WBGene00007440 Caenorhabditis elegans From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00020747 Caenorhabditis elegans From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00010436 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00012927 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00012968 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00016495 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00020052 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: irg-1 encodes a protein containing a conserved DUF1768 domain, a domain of unknown function found as a stand-alone domain in bacterial and bacteriophage proteins as well as fused to proteins involved in riboflavin biosynthesis in bacteria and plants; irg-1 expression is induced in response to infection with pathogenic Pseudomonas aeruginosa, in a manner independent of the p38 MAPK pathway, but dependent upon the ZIP-2 bZIP transcription factor; irg-1 expression is also induced at a low level in response to cadmium exposure, in a manner that is dependent upon pmk-1. Paper_evidence: WBPaper00028789
            WBPaper00035891
          Curator_confirmed: WBPerson1843
          Date_last_updated: 08 Feb 2010 00:00:00
      Automated_description: Involved in antibacterial innate immune response and defense response to Gram-negative bacterium. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C07G3.2
    Corresponding_transcript: C07G3.2.1
    Other_sequence: CBC16326_1
    Associated_feature: WBsf231582
  Experimental_info: RNAi_result: WBRNAi00040026 Inferred_automatically: RNAi_primary
      WBRNAi00010403 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8898
      Expr1028122
      Expr1144099
      Expr2012816
      Expr2031055
    Drives_construct: WBCnstr00005926
      WBCnstr00013591
      WBCnstr00028740
    Construct_product: WBCnstr00020134
      WBCnstr00028740
    Microarray_results (19)
    Expression_cluster: WBPaper00032479:CB4856vsN2_LifeStageProfile_Variation
      WBPaper00037950:intestine_larva_enriched
      WBPaper00037950:intestine_larva_SelectivelyEnriched
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00038237:age-1_upregulated_intestine_rescue
      WBPaper00038237:age-1_upregulated_neuron_rescue
      WBPaper00038237:age-1_upregulated_nontransgenic
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00040285:H2S_24hr_downregulated
      WBPaper00040560:hpl-2_L3_downregulated
      WBPaper00041954:ethanol_upregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00042561:smgl-2(RNAi)_upregulated
      WBPaper00043945:MeHg_downregulated
      WBPaper00044030:nhr-8(hd117)_upregulated
      WBPaper00044316:CH3HgCl_7.5uM_upregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044760:somatic_specific
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045257:bar-1(ga80)_upregulated
      WBPaper00045417:128Q-huntingtin_downreglated
      WBPaper00045934:wrn-1(gk99)_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00046509:lin-35(n745)_upregulated
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00049018:ham-3(RNAi)_downregulated
      WBPaper00049134:hpk-1(pk1393)_upregulated
      WBPaper00049290:rsks-1(sv31)_upregulated
      WBPaper00049334:CE_intestine_enriched
      WBPaper00049377:MWCNT_downregulated
      WBPaper00049905:Age_variant_expression
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049920:hyl-2(tm2031)_upregulated
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00049954:BPA_upregulated
      WBPaper00049954:BPS_upregulated
      WBPaper00050182:lmn-1(L535P)_upregulated
      WBPaper00050193:cec-4(ok3124)_upregulated_L1
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050504:hrp-2(RNAi)_upregulated
      WBPaper00050686:glp-1(e2141)_upregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050801:SET-4_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:hypodermis_enriched
      WBPaper00050990:hypodermis_expressed
      WBPaper00051021:4-bromodiphenyl-ether_upregulated
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053020:sid-3(ok973)_upregulated
      WBPaper00053020:sta-1(ok587)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053402:his-3(RNAi)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053771:up_at_24h-NaCl
      WBPaper00053810:clk-1(qm30)_downregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053810:sod-2(ok1030)_upregulated
      WBPaper00053888:drh-3(rrr2)_downregulated
      WBPaper00054191:H3.3(null)_L1_downregulated
      WBPaper00054810:deoxynivalenol_upregulated
      WBPaper00055137:S.maltophilia_upregulated
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055386:daf-2(e1370)_downregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056034:pals-25(jy9)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056167:Cry5B_downregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_L4
      WBPaper00056218:daf-16(mu86)_downregulated_Day5
      WBPaper00056218:daf-16(mu86)_downregulated_Day7
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056330:glycine_downregulated
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056586:kri-1(ok1251)_upregulated
      WBPaper00056617:adr-1_upregulated_embryo_transcript
      WBPaper00056826:hmc_biased
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00057041:spc-1(cas971)_downregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057068:Cadmium_upregulated
      WBPaper00057068:ints-4(RNAi)_upregulated
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057265:metaformin_downregulated_OP50
      WBPaper00057265:metaformin_downregulated_OP50-MR
      WBPaper00057347:nhr-14(tm1473)_upreglated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_OP50
      WBPaper00058948:PA14_downregulated
      WBPaper00058955:heatshock_upregulated_CE
      WBPaper00059175:hlh-17p-XBP-1_upregulated
      WBPaper00059231:alh-6(lax105)_L4_downregulated
      WBPaper00059253:sucrose_downregulated
      WBPaper00059253:sucrose_stearic-acid_downregulated
      WBPaper00059378:cec-4(ok3124);lmn-1(Y59C)_vs_lmn-1(Y59C)_downregulated
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059735:glucose_downregulated_lpin-1(RNAi)
      WBPaper00059735:glucose_downregulated_N2
      WBPaper00059739:hira-1(gk835598)_downregulated_L1
      WBPaper00059754:E.faecalis_OG1RF_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:CoCl2_6hr_upregulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060434:pH4.33_vs_pH6.33_uprgulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060764:swsn-9(ok1354)_upregulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640)
      WBPaper00061081:skpo-1(ok1640)_upregulated_OG1RF
      WBPaper00061106:endu-2(tm4977)_upregulated
      WBPaper00061274:hypergravity_15xg_downregulated
      WBPaper00061340:AIZ
      WBPaper00061340:Rectal_gland
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061390:daf-22(ok693)_ascarosides_upregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061466:nath-10(icb99)_downregulated
      WBPaper00061527:C10C5.2-Y58A7A.3
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00061613:human-amyloid-beta_downregulated
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061902:camt-1(ok515)_regulated_BAG
      WBPaper00061995:mter-4(syb3662syb3403)_upregulated
      WBPaper00062056:lin-35(n745)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062354:H.zoospora_12h_regulated
      WBPaper00062440:crh-1(syb385)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062456:doxycycline_upregulated_CB4856_transcript
      WBPaper00062456:doxycycline_upregulated_N2_transcript
      WBPaper00062497:xpf-1(tm2842)_upregulated
      WBPaper00062520:qui-1(db104)_downregulated
      WBPaper00062590:Aging_upregulated_intestine
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00062684:pathogen_upregulated_N2
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064130:Beta-Amyloid_8h_downregulated_mRNA
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064505:tamoxifen_downregulated
      WBPaper00064509:static-magnetic-field_upregulated
      WBPaper00064532:pals-22(jy3)_upregulated
      WBPaper00064532:pals-25(icb98)_upregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064637:cox-5B(RNAi)_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064871:PA14_upregulated_AWA
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00064999:miR-229-64-65-66_upregulated
      WBPaper00065029:cadmium_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
      WBPaper00065288:mdt-15(tm2182)_upregulated
      WBPaper00065315:mating_upregulated_Day2-7
      WBPaper00065331:100nM-ivermectin_upregulated
      WBPaper00065392:Lb.delbrueckii_upregulated
      WBPaper00065560:E.coli-HB101_upregulated_P0
      WBPaper00065734:unc-25(e156)_upregulated
      WBPaper00065746:tmc-1(rg1003)_upregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2
      WBPaper00065841:13_0
      WBPaper00065841:30_0
      WBPaper00065841:106_0
      WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066004:ceh-14(ch3)_downregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066204:CdCl2_upregulated_mRNA
      WBPaper00066232:hsf-1(RNAi)_upregulated_WT
      cgc4489_group_23
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026952:class_E
      WBPaper00026980:intestine_enriched
      WBPaper00027111:eri-1(mg366)_upregulated
      WBPaper00028482:PA14_upregulated
      WBPaper00028789:PA14_vs_gacA_upregulated_4hr
      WBPaper00028789:PA14_vs_gacA_upregulated_8hr
      WBPaper00028789:PA14_vs_OP50_upregulated_4hr
      WBPaper00028789:PA14_vs_OP50_upregulated_8hr
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035891:PA_induced_zip-2_dependent
      WBPaper00035891:zip-2(RNAi)_downregulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_D
      WBPaper00036383:ash-2_L3_regulated
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00037695:LD_3-day
      WBPaper00038172:crh-1null_up_regulated
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038304:octr-1_regulated
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040998:nhr-66_regulated
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041876:daf-10(m79)_downreglated
      WBPaper00041906:I-4317_vs_OP50_10d
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042067:Cu2+_upregulated_kgb-1_top50
      WBPaper00042067:Cu2+_upregulated_kgb-1_top66
      WBPaper00042067:Cu2+_upregulated_WT
      WBPaper00042128:gei-8(ok1671)_upregulated
      WBPaper00044013:nasp-1_downregulated
      WBPaper00044091:Bpseudomallei_induced_2h
      WBPaper00044091:Bpseudomallei_induced_4h
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00044091:Bpseudomallei_induced_12h
      WBPaper00044535:male_upregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00046083:pmk-1(km25)_OP50_downregulated
      WBPaper00046548:dafachronic-acid_downregulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated
      WBPaper00047070:DAF-16-dependent_UV_response
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00050515:nipi-3(fr4)_upregulated
      WBPaper00050520:lagr-1(gk327);hyl-1(ok976)_upregulated
      WBPaper00050650:mBmkTX_upregulated
      WBPaper00051448:P.aeruginosa_Liquid-Killing_upregulated
      WBPaper00051448:P.aeruginosa_Slow-Killing_upregulated
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
      [cgc6390]:Cluster_A
    Interaction (63)
    WBProcess: WBbiopr:00000008
      WBbiopr:00000039
  Map_info: Map: V Position: -10.3139 Error: 0.017317
    Positive: Positive_clone: C07G3 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (17)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene