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WormBase Tree Display for Gene: WBGene00020930

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Name Class

WBGene00020930SMapS_parentSequenceCHROMOSOME_IV
IdentityVersion2
NameCGC_namehlh-30Person_evidenceWBPerson216
WBPerson1997
WBPerson346
Sequence_nameW02C12.3
Molecular_name (33)
Other_nameCELE_W02C12.3Accession_evidenceNDBBX284604
Public_namehlh-30
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:31:03WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
216 Jun 2006 16:28:49WBPerson2970Name_changeCGC_namehlh-30
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classhlh
AlleleWBVar01491607
WBVar01581019
WBVar01649638
WBVar01581020
WBVar01649639
WBVar01581021
WBVar01581022
WBVar01649640
WBVar01581023
WBVar01649641
WBVar01649642
WBVar01581024
WBVar02082348
WBVar01489059
WBVar01668679
WBVar01668680
WBVar00902259
WBVar01668681
WBVar00902260
WBVar01668682
WBVar00902261
WBVar00902262
WBVar00902263
WBVar00902264
WBVar00902265
WBVar01451993
WBVar00902266
WBVar00902267
WBVar01451995
WBVar00902268
WBVar02020473
WBVar00902269
WBVar02020474
WBVar02020475
WBVar00902270
WBVar02020476
WBVar00902271
WBVar02020477
WBVar00902272
WBVar00902273
WBVar02020478
WBVar00902274
WBVar00902275
WBVar01481718
WBVar01630534
WBVar00902276
WBVar01630535
WBVar01481719
WBVar01630536
WBVar00902277
WBVar01727264
WBVar00902278
WBVar01630537
WBVar01727265
WBVar01630538
WBVar00902279
WBVar01630539
WBVar01727266
WBVar00902280
WBVar00902281
WBVar01727267
WBVar01630540
WBVar01630541
WBVar00902282
WBVar01727268
WBVar00902283
WBVar01630542
WBVar01727269
WBVar01630543
WBVar00902284
WBVar01727270
WBVar01630544
WBVar00902285
WBVar01923064
WBVar01727271
WBVar01727272
WBVar01630545
WBVar00902286
WBVar01923065
WBVar01727273
WBVar01923066
WBVar01630546
WBVar00902287
WBVar01727274
WBVar00902288
WBVar01923067
WBVar01630547
WBVar01492404
WBVar01727275
WBVar01923068
WBVar01630548
WBVar00902289
WBVar02003817
WBVar00902290
WBVar01923069
WBVar01630549
WBVar02094348
WBVar02003818
WBVar01727276
WBVar02034486
WBVar01923070
WBVar02094349
WBVar00902291
WBVar01630550
WBVar02003819
WBVar01727277
WBVar01727278
WBVar01923071
WBVar00902292
WBVar01630551
WBVar01923072
WBVar00902293
WBVar01630552
WBVar01727279
WBVar01923073
WBVar00902294
WBVar01630553
WBVar01823640
WBVar01727280
WBVar00902295
WBVar01727281
WBVar01630554
WBVar01923074
WBVar01923075
WBVar01630555
WBVar00902296
WBVar01908512
WBVar01727282
WBVar01727283
WBVar01630556
WBVar00902297
WBVar01630557
WBVar00902298
WBVar00902299
WBVar00422479
WBVar01630558
WBVar00902300
WBVar01630559
WBVar00422480
WBVar00902301
WBVar01630560
WBVar00422481
WBVar00902302
WBVar01630561
WBVar00142324
WBVar00422482
WBVar00422483
WBVar01630562
WBVar00902303
WBVar00902304
WBVar01630563
WBVar00422484
WBVar00422485
WBVar00902305
WBVar01630564
WBVar00902306
WBVar01630565
WBVar00422486
WBVar00902307
WBVar00422487
WBVar02103566
WBVar00422488
WBVar00902308
WBVar02103567
WBVar00422489
WBVar00902309
WBVar00902310
WBVar00422490
WBVar00902311
WBVar02077781
WBVar00422491
WBVar00422492
WBVar00902312
WBVar00422493
WBVar00902313
WBVar01499790
WBVar00422494
WBVar00902314
WBVar00422495
WBVar00902315
WBVar00902316
WBVar00422496
WBVar00902317
WBVar00422497
WBVar00902318
WBVar00422498
WBVar00902319
WBVar00422499
WBVar01548995
WBVar00902320
WBVar00422500
WBVar00902321
WBVar00422501
WBVar00422502
WBVar00902322
WBVar00902323
WBVar00422503
WBVar00902324
WBVar00422504
WBVar00902325
WBVar00422505
WBVar00902326
WBVar00422506
WBVar00422507
WBVar00902327
WBVar00422508
WBVar00902328
WBVar00422509
WBVar00902329
WBVar00422510
WBVar00902330
WBVar00902331
WBVar00422511
WBVar00902332
WBVar00422512
WBVar00422513
WBVar01687931
WBVar00902333
WBVar00422514
WBVar00902334
WBVar00902335
WBVar00259208
WBVar00422515
WBVar00422516
WBVar00902336
WBVar00422517
WBVar00902337
WBVar00902338
WBVar00422518
WBVar00902339
WBVar00422519
WBVar00258108
WBVar00422520
WBVar00902340
WBVar01499633
WBVar00422521
WBVar00902341
WBVar01515336
WBVar00902342
WBVar00422522
WBVar00902343
WBVar00422523
WBVar01904325
WBVar01515337
WBVar00422524
WBVar00902344
WBVar01515338
WBVar01904326
WBVar00902345
WBVar00422525
WBVar01515339
WBVar00902346
WBVar00422526
WBVar01515340
WBVar02073340
WBVar01515341
WBVar00422527
WBVar00902347
WBVar01515342
WBVar00422528
WBVar00902348
WBVar00902349
WBVar00422529
WBVar00422530
WBVar00902350
WBVar00902351
WBVar01568593
WBVar00422531
WBVar00902352
WBVar01568594
WBVar00422532
WBVar00308087
WBVar02089994
WBVar01568595
WBVar00902353
WBVar00422533
WBVar02151184
WBVar00422534
WBVar01568596
WBVar00902354
WBVar02119993
WBVar00422535
WBVar01568597
WBVar00902355
WBVar00422536
WBVar01568598
WBVar00902356
WBVar00601416
WBVar00902357
WBVar01568599
WBVar02031140
WBVar01990796
WBVar00250938
WBVar00902358
WBVar01990797
WBVar00902359
WBVar00902360
WBVar01990798
WBVar00902361
WBVar02151560
WBVar01990799
WBVar00188260
WBVar00902362
WBVar01990800
WBVar00188261
WBVar01990801
WBVar00902363
WBVar00188262
WBVar00188263
WBVar01990802
WBVar00902364
WBVar00188264
WBVar01990803
WBVar00902365
WBVar00902366
WBVar00188265
WBVar01990804
WBVar00902367
WBVar00188266
WBVar01990805
WBVar00252974
WBVar00902368
WBVar00188267
WBVar01990806
WBVar00902369
WBVar00188268
WBVar01990807
WBVar00902370
WBVar01990808
WBVar00188269
WBVar00188270
WBVar01990809
WBVar00902371
WBVar00188271
WBVar00902372
WBVar00188272
WBVar00902373
WBVar00902374
WBVar00188273
WBVar00902375
WBVar00188274
WBVar00188275
WBVar00902376
WBVar00902377
WBVar00188276
WBVar00902378
WBVar00188277
WBVar00902379
WBVar00188278
WBVar00188279
WBVar00902380
WBVar00902381
WBVar00188280
WBVar00902382
WBVar00188281
WBVar00571933
WBVar00902383
WBVar00188282
WBVar00571938
WBVar00188283
WBVar00902384
WBVar00571940
WBVar00902385
WBVar00188284
WBVar01997204
WBVar00188285
WBVar00571952
WBVar00902386
WBVar01966138
WBVar01966139
WBVar01997205
WBVar00188286
WBVar00571953
WBVar00902387
WBVar00188287
WBVar01966140
WBVar00902388
WBVar00188288
WBVar01966141
WBVar00902389
WBVar01966142
WBVar00188289
WBVar00188290
WBVar01966143
WBVar00254477
WBVar01966144
WBVar01966145
WBVar01966146
WBVar01966147
WBVar01966148
WBVar01966149
WBVar01966150
WBVar02133691
WBVar02133692
WBVar02133693
WBVar02133694
WBVar02133695
WBVar02133696
StrainWBStrain00001702
WBStrain00002268
WBStrain00001379
WBStrain00002364
WBStrain00022468
WBStrain00051498
RNASeq_FPKM (74)
GO_annotation (43)
Ortholog (50)
Structured_descriptionConcise_descriptionhlh-30 encodes a predicted basic helix-loop-helix (bHLH) transcription factor, one of 42 such genes in the C. elegans genome, it is spliced to give 18 different transcripts; it is orthologous to human microphthalmia-associated transcription factor (HGNC:MITF); loss of hlh-30 activity via RNAi results in reduced fat storage; HLH-30 demonstrates sequence-specific DNA binding for the E box sequence CACGTG and likely binds DNA as a homodimer; expression profiles of hlh-30 mutants indicate that, like its human ortholog, HLH-30 regulates expression of genes involved in metabolism; at least one of the bHLH protein isoforms appears to be important for an infection-specific immune response to M. nematophilum, though the overall induction of this gene following infection was not appreciable (1.3-fold).Paper_evidenceWBPaper00005655
WBPaper00034761
WBPaper00027722
WBPaper00027046
Curator_confirmedWBPerson324
Date_last_updated30 Nov 2009 00:00:00
Automated_descriptionPredicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to bacterium; determination of adult lifespan; and positive regulation of metabolic process. Acts upstream of or within positive regulation of plasma membrane repair and positive regulation of xenophagy. Located in cytoplasm and nucleus. Expressed in several structures, including nerve ring; rectal valve cell; somatic cell; spermatheca; and vulva. Human ortholog(s) of this gene implicated in several diseases, including Tietz syndrome; Tietze's syndrome; and Waardenburg syndrome type 2A. Is an ortholog of human TFE3 (transcription factor binding to IGHM enhancer 3) and TFEC (transcription factor EC).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:4450Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11752)
DOID:14021Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7105)
DOID:6846Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7105)
DOID:0110950Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7105)
DOID:1909Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7105)
DOID:9258Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7105)
DOID:0090002Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7105)
Molecular_infoCorresponding_CDSW02C12.3a
W02C12.3b
W02C12.3c
W02C12.3d
W02C12.3e
W02C12.3f
W02C12.3g
W02C12.3h
W02C12.3i
W02C12.3j
Corresponding_transcript (13)
Other_sequence (16)
Associated_feature (50)
Transcription_factorWBTranscriptionFactor000085
Experimental_infoRNAi_result (28)
Expr_pattern (18)
Drives_construct (14)
Construct_productWBCnstr00016821
WBCnstr00016897
WBCnstr00018058
WBCnstr00018059
WBCnstr00018600
WBCnstr00022988
WBCnstr00024778
Regulate_expr_clusterWBPaper00034761:hlh-30_downregulated
WBPaper00034761:hlh-30_upregulated
WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
WBPaper00050468:hlh-30-dependent_Cry5B_regulated
WBPaper00065993:hlh-30(RNAi)-neuron_downregulated
WBPaper00065993:hlh-30(RNAi)-neuron_upregulated
Microarray_results (63)
Expression_cluster (171)
Interaction (63)
Map_infoMapIVPosition-1.01381Error0.019046
PositivePositive_cloneW02C12Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (102)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene