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WormBase Tree Display for Gene: WBGene00006788

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Name Class

WBGene00006788SMapS_parentSequenceCHROMOSOME_II
IdentityVersion1
NameCGC_nameunc-53Person_evidenceWBPerson261
Sequence_nameF45E10.1
Molecular_name (24)
Other_nameCELE_F45E10.1Accession_evidenceNDBBX284602
Public_nameunc-53
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:42WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Reference_alleleWBVar00143183
AlleleWBVar00143183Inferred_automaticallyFrom strain object: CB404
From strain object: DG1255
WBVar00089600Inferred_automaticallyFrom strain object: MT1580
From strain object: ST13
From strain object: ST30
WBVar00597508Inferred_automaticallyFrom strain object: VC2036
WBVar00144851
WBVar00000326
WBVar00766705
WBVar01376395
WBVar00766706
WBVar00093838
WBVar01477989
WBVar00766707
WBVar01499702
WBVar01477990
WBVar00766708
WBVar00766709
WBVar00766710
WBVar00766711
WBVar01394127
WBVar01500075
WBVar00252100
WBVar00229699
WBVar00766712
WBVar01538652
WBVar00766713
WBVar01538653
WBVar00766714
WBVar01538654
WBVar00766715
WBVar00766716
WBVar01538655
WBVar00766717
WBVar00766718
WBVar00089288
WBVar00766719
WBVar00766720
WBVar00766721
WBVar00089294
WBVar01817679
WBVar00766722
WBVar00766723
WBVar00766724
WBVar02125085
WBVar00766725
WBVar00766726
WBVar00766727
WBVar00766543
WBVar00766728
WBVar00766544
WBVar00766545
WBVar01498435
WBVar00766729
WBVar00766730
WBVar00766546
WBVar00766731
WBVar01604981
WBVar00766547
WBVar00766732
WBVar01604982
WBVar00766548
WBVar00766733
WBVar00766549
WBVar00766550
WBVar00766734
WBVar00766735
WBVar00766551
WBVar00766736
WBVar00766552
WBVar00766737
WBVar00766553
WBVar00766554
WBVar00766555
WBVar00229748
WBVar00766556
WBVar00766557
WBVar00766558
WBVar00234899
WBVar00305220
WBVar00766559
WBVar00766560
WBVar01912169
WBVar01825451
WBVar00766561
WBVar00229760
WBVar00766562
WBVar00229761
WBVar00766563
WBVar00766564
WBVar00766565
WBVar01895352
WBVar00766566
WBVar00229766
WBVar00766567
WBVar01895353
WBVar00766568
WBVar01895354
WBVar00766569
WBVar01895355
WBVar01895356
WBVar00766570
WBVar00766571
WBVar01895357
WBVar00766572
WBVar00766573
WBVar00766574
WBVar00766575
WBVar00766576
WBVar00766577
WBVar00766578
WBVar00766579
WBVar00766580
WBVar01851260
WBVar00766581
WBVar00766582
WBVar00766583
WBVar00766584
WBVar01792280
WBVar00766585
WBVar01943563
WBVar00766586
WBVar00275813
WBVar01846659
WBVar00766587
WBVar02068245
WBVar00766588
WBVar00766589
WBVar00766590
WBVar01784511
WBVar00766591
WBVar00766592
WBVar01784512
WBVar00766593
WBVar01784513
WBVar00766594
WBVar01784514
WBVar00766595
WBVar01784515
WBVar00229820
WBVar01784516
WBVar00766596
WBVar00766597
WBVar00766598
WBVar00766599
WBVar00766600
WBVar00766601
WBVar01960264
WBVar00766602
WBVar01960265
WBVar00766603
WBVar00766604
WBVar00377592
WBVar00276580
WBVar00766605
WBVar00276581
WBVar00377593
WBVar00766606
WBVar00377594
WBVar00766607
WBVar00766608
WBVar00377595
WBVar01499235
WBVar00766609
WBVar00377596
WBVar00766610
WBVar00377597
WBVar00377598
WBVar00766611
WBVar00377599
WBVar00766612
WBVar00598482
WBVar00377600
WBVar00309777
WBVar00598483
WBVar00144830
WBVar00766613
WBVar00766614
WBVar00377601
WBVar01935590
WBVar01546923
WBVar00766615
WBVar00377602
WBVar01935591
WBVar00377603
WBVar01935592
WBVar01546924
WBVar00766616
WBVar00766617
WBVar01546925
WBVar01935594
WBVar00377604
WBVar00766618
WBVar00377605
WBVar01546926
WBVar00377606
WBVar01546927
WBVar00766619
WBVar00766620
WBVar01546928
WBVar00377607
WBVar00377608
WBVar01546930
WBVar00766621
WBVar00377609
WBVar01546931
WBVar01254662
WBVar00766622
WBVar01902629
WBVar00377610
WBVar00766623
WBVar01902630
WBVar00377611
WBVar00766624
WBVar00766625
WBVar01902631
WBVar00377612
WBVar01311347
WBVar00766626
WBVar00377613
WBVar00766627
WBVar01311358
WBVar00377614
WBVar00766628
WBVar01311359
WBVar00377615
WBVar01311360
WBVar00377616
WBVar00766629
WBVar00262886
WBVar00766630
WBVar00377617
WBVar01254673
WBVar00377618
WBVar00766631
WBVar01311363
WBVar00766632
WBVar00377619
WBVar01311364
WBVar00377620
WBVar01311368
WBVar00766633
WBVar00377621
WBVar01989346
WBVar01311369
WBVar00766634
WBVar00377622
WBVar01311370
WBVar00766635
WBVar00766636
WBVar00377623
WBVar02033539
WBVar00377624
WBVar00766637
WBVar00377625
WBVar00766638
WBVar01254684
WBVar00552866
WBVar00377626
WBVar00766639
WBVar00766640
WBVar00377627
WBVar01826637
WBVar00552877
WBVar00766641
WBVar00377628
WBVar00766642
WBVar00377629
WBVar01413903
WBVar00377630
WBVar00766643
WBVar00766644
WBVar00377631
WBVar00377632
WBVar00766645
WBVar00377633
WBVar00766646
WBVar00766647
WBVar00377634
WBVar00377635
WBVar00766648
WBVar00766649
WBVar00175593
WBVar00377636
WBVar00175594
WBVar00229896
WBVar00377637
WBVar00766650
WBVar00175595
WBVar00377638
WBVar00766651
WBVar00377639
WBVar00766652
WBVar00175596
WBVar00766653
WBVar00377640
WBVar00105956
WBVar00229901
WBVar00175599
WBVar00105957
WBVar00766654
WBVar00377641
WBVar00175600
WBVar00142567
WBVar00175601
WBVar00377642
WBVar00257943
WBVar00766655
WBVar00105958
WBVar00175602
WBVar00377643
WBVar00766656
WBVar00229910
WBVar00766657
WBVar00377644
WBVar00175603
WBVar00766658
WBVar00377645
WBVar00175604
WBVar00766659
WBVar00175605
WBVar00377646
WBVar00766660
WBVar00175606
WBVar00377647
WBVar00377648
WBVar00175607
WBVar00766661
WBVar02130692
WBVar00175608
WBVar00377649
WBVar00766662
WBVar02130693
WBVar00766663
WBVar00377650
WBVar00766664
WBVar00377651
WBVar00377652
WBVar00766665
WBVar00377653
WBVar00766666
WBVar00766667
WBVar00377654
WBVar00766668
WBVar00238688
WBVar00377655
WBVar02052787
WBVar00766669
WBVar01244469
WBVar00377656
WBVar00377657
WBVar00766670
WBVar00766671
WBVar00377658
WBVar00377659
WBVar00766672
WBVar01244480
WBVar01685366
WBVar00377660
WBVar00766673
WBVar01244482
WBVar01685367
WBVar00377661
WBVar01244483
WBVar00766674
WBVar01244484
WBVar00766675
WBVar00377662
WBVar00766676
WBVar00377663
WBVar00766677
WBVar00238697
WBVar01244486
WBVar00377664
WBVar00766678
WBVar01439775
WBVar01244490
WBVar00377665
WBVar00377666
WBVar01439780
WBVar01244492
WBVar00766679
WBVar00766680
WBVar00377667
WBVar01439782
WBVar02086346
WBVar00377668
WBVar00766681
WBVar01498940
WBVar01439783
WBVar01439785
WBVar00377669
WBVar00766682
WBVar01439787
WBVar00766683
WBVar00377670
WBVar00377671
WBVar01439788
WBVar00766684
WBVar01439790
WBVar00766685
WBVar01439792
WBVar00766686
WBVar00307718
WBVar01439794
WBVar00766687
WBVar01439796
WBVar00766688
WBVar00766689
WBVar00766690
WBVar00766691
WBVar00766692
WBVar01998884
WBVar00766693
WBVar00766694
WBVar01496744
WBVar00766695
WBVar00766696
WBVar00766697
WBVar00766698
WBVar00766699
WBVar00766700
WBVar00766701
WBVar00106005
WBVar00766702
WBVar00766703
WBVar00766704
Legacy_informatione404 : sluggish poor backing dumpyish somewhat Egl; males have abnormal bursal anatomy. ES2 ME0. NA4 (n152 n166 n569).
See also e2432, e2499, n152, n166, n569
[C.elegansII] e404 : sluggish, poor backing, dumpyish; somewhat Egl; multiple defects in neuronal outgrowth, branching; also defects in excretory canal extension, gonad arm growth; males have abnormal bursal anatomy. ES2 ME0. OA>5: n152, n166, n569 (synergizes with sem-5(n177) to give strong Sem migration defect),e2432, e2499, etc. Null phenotype uncertain; some lethality in strong alleles. Cloned: multiple transcripts (different 5' ends); one encodes 1528 aa protein, predicted to bind actin, ATP/GTP; may interact with SEM-5. Transgene overexpression leads to extension of growth cones along a-p axis. [Hedgecock et al. 1987; Hekimi and Kershaw 1993; UG]
StrainWBStrain00026706
WBStrain00026870
WBStrain00032757
WBStrain00034470
WBStrain00034483
WBStrain00037045
WBStrain00004162
WBStrain00004572
WBStrain00005655
RNASeq_FPKM (74)
GO_annotation (21)
Ortholog (46)
Structured_descriptionConcise_descriptionunc-53 encodes at least five large (~1200-1600 residue) proteins, orthologous to human NAV1, NAV2/RAINB1 (OMIM:607026), and NAV3, and homologous to Drosophila CG10662; UNC-53 proteins are required for anteroposterior guidance of migrating cells, axons, and excretory cell canals; unc-53 mutations affect egg laying, backward locomotion, body size, and male mating; UNC-53 proteins vary in their N-terminal regions but share common C-terminal sequences with a AAA-ATPase domain; the UNC-53 N-terminus physically interacts with ABI-1, suggesting that UNC-53 may function as a scaffold to link the ARP2/3 complex to ABI-1; UNC-53 also interacts both physically and genetically with SEM-5; unc-53 is expressed in those cells requiring it, suggesting that its function is cell-autonomous; overexpression of unc-53 induces excess cellular outgrowth.Paper_evidence (11)
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated13 Nov 2012 00:00:00
Automated_descriptionPredicted to enable actin filament binding activity. Involved in several processes, including backward locomotion; positive regulation of locomotion; and reproductive behavior. Located in cytoplasm. Expressed in several structures, including excretory cell; hermaphrodite distal tip cell; neurons; non-striated muscle; and socket cell. Is an ortholog of human NAV1 (neuron navigator 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:2559Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:15998)
Molecular_infoCorresponding_CDSF45E10.1a
F45E10.1b
F45E10.1c
F45E10.1d
F45E10.1e
F45E10.1f
F45E10.1g
F45E10.1h
Corresponding_CDS_historyF45E10.1:wp82
Corresponding_transcriptF45E10.1a.1
F45E10.1b.1
F45E10.1c.1
F45E10.1d.1
F45E10.1e.1
F45E10.1f.1
F45E10.1g.1
F45E10.1h.1
Other_sequence (27)
Associated_feature (66)
Experimental_infoRNAi_result (14)
Expr_pattern (12)
Drives_construct (25)
Construct_productWBCnstr00009444
WBCnstr00010519
WBCnstr00010520
WBCnstr00010521
WBCnstr00034150
AntibodyWBAntibody00001615
WBAntibody00001625
Microarray_results (40)
Expression_cluster (219)
Interaction (103)
Anatomy_functionWBbtf0113
WBbtf0114
WBbtf0118
WBbtf0119
Map_infoMapIIPosition3.16568Error0.005694
Well_ordered
PositivePositive_cloneF45E10Inferred_automaticallyFrom sequence, transcript, pseudogene data
T28D2
Mapping_data2_point43
Multi_point (11)
Pos_neg_data2145
2146
2159
2163
4533
4534
4535
4536
4539
10562
Reference (99)
MethodGene