WormBase Tree Display for Gene: WBGene00006741
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| WBGene00006741 | SMap | S_parent | Sequence | K03E6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-1 | Person_evidence | WBPerson261 | |||||
| Sequence_name | K03E6.5 | ||||||||
| Molecular_name | K03E6.5a | ||||||||
| K03E6.5a.1 | |||||||||
| CE28585 | |||||||||
| K03E6.5b | |||||||||
| CE42275 | |||||||||
| K03E6.5b.1 | |||||||||
| Other_name | unc-102 | ||||||||
| CELE_K03E6.5 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | unc-1 | ||||||||
| DB_info | Database | AceView | gene | XB678 | |||||
| WormQTL | gene | WBGene00006741 | |||||||
| WormFlux | gene | WBGene00006741 | |||||||
| NDB | locus_tag | CELE_K03E6.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006741|UniProtKB=Q21190 | |||||||
| family | PTHR10264 | ||||||||
| NCBI | gene | 180458 | |||||||
| RefSeq | mRNA | NM_001129690.5 | |||||||
| NM_075801.7 | |||||||||
| protein | NP_508202.1 | ||||||||
| NP_001123162.1 | |||||||||
| SwissProt | UniProtAcc | Q21190 | |||||||
| TrEMBL | UniProtAcc | G5ED08 | |||||||
| UniProt_GCRP | UniProtAcc | Q21190 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Allele (97) | |||||||||
| Legacy_information | lass 1 (loss-of-function) e719 : putative null recessive kinker. ES3 NA (recessive) > 10. unc-1 Class 3 (neomorph/antimorph) e94sd (former reference allele) : recessive kinker e94/+ is weak coiler ES2 ME2; e1598dm (pka unc-102) : both homozygote and e1598/+ are strong coilers resistant to aldicarb (cholinesterase inhibitor); intragenic revertants of e1598 have Class 1 phenotype. ES3 ME0. NA (dominant) > 8. Complex complementation among unc-1 alleles. | ||||||||
| See unc-1. | |||||||||
| See also e1598, e2380, e2381, n494, n496, n774, n775, n779, n782, n783, n784, n1166, n1167, n1200, n1201, n1202, n1203, n1204, n1205, n1206, n1207, n1208, n1209 | |||||||||
| [C.elegansII] e719 : recessive kinker, putative null. Suppresses anaesthetic hypersensitivity of unc-79 and unc-80 mutants. ES3 ME1. OA>10(recessive): e50, e68, e114 (anomalous allele, transdominant suppressor of n494sd), etc. Also neomorph/antimorph gf alleles: e94sd (former reference allele, recessive kinker; e94/+ is weak coiler. ES2 ME2), e1598dm (pka unc-102, both homozygote and e1598/+ are strong Ric coilers; intragenic revertants of e1598 resemble e719. ES3 ME0). OA>8 (dominant and semidominant);n496, n775 (strongly dominant), n494 (weaklysemidominant), etc. Complex complementation among unc-1 alleles. [Park and Horvitz 1986a; Morgan and Sedensky 1994; CW] | |||||||||
| Strain (37) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Ortholog (29) | |||||||||
| Paralog | WBGene00003166 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006063 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006064 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006065 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006066 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006067 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006068 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006761 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006061 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | unc-1 encodes one of ten C. elegans stomatin-like proteins (SLPs) homologous to human erythrocyte surface protein band 7.2 (EPB72/Stomatin) (OMIM:133090; deficient in stomatocytosis); UNC-1 activity regulates electrical coupling between body wall muscles and is required in neurons for normal locomotion; unc-1 is also required for anesthetic sensitivity; an unc-1 promoter::DsRED2 fusion is expressed in body wall muscle, vulval muscle, anal-depressor muscle, stomatointestinal muscle, nearly all ventral cord motor neurons and the nerve ring; in neurons and body wall muscle, UNC-1 colocalizes with UNC-9, an innexin, at intercellular junctions; unc-24, which also encodes a stomatin homolog, is epistatic to unc-1 and required for UNC-1 localization in the nerve ring. | Paper_evidence | WBPaper00000031 | |||||
| WBPaper00004649 | |||||||||
| WBPaper00030879 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 18 Jul 2008 00:00:00 | ||||||||
| Automated_description | Enables ion channel regulator activity. Involved in positive regulation of cell communication by electrical coupling and response to xenobiotic stimulus. Located in axon and gap junction. Expressed in several structures, including enteric muscle; ganglia; head neurons; somatic nervous system; and vulval muscle. | Curator_confirmed | WBPerson324 | ||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS285 version of WormBase | ||||||||
| Date_last_updated | 07 Jun 2022 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | K03E6.5a | |||||||
| K03E6.5b | |||||||||
| Corresponding_CDS_history | K03E6.5:wp188 | ||||||||
| Corresponding_transcript | K03E6.5a.1 | ||||||||
| K03E6.5b.1 | |||||||||
| Other_sequence (59) | |||||||||
| Associated_feature | WBsf670099 | ||||||||
| WBsf1003931 | |||||||||
| WBsf1003932 | |||||||||
| WBsf1022206 | |||||||||
| WBsf1022207 | |||||||||
| WBsf1022208 | |||||||||
| WBsf236994 | |||||||||
| WBsf236995 | |||||||||
| WBsf236996 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00103042 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00049837 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr527 | ||||||||
| Expr887 | |||||||||
| Expr3407 | |||||||||
| Expr4819 | |||||||||
| Expr1022667 | |||||||||
| Expr1032816 | |||||||||
| Expr1153550 | |||||||||
| Drives_construct | WBCnstr00012258 | ||||||||
| WBCnstr00012259 | |||||||||
| WBCnstr00012423 | |||||||||
| WBCnstr00014590 | |||||||||
| WBCnstr00019884 | |||||||||
| WBCnstr00034181 | |||||||||
| Construct_product | WBCnstr00012423 | ||||||||
| WBCnstr00023065 | |||||||||
| WBCnstr00034181 | |||||||||
| WBCnstr00042106 | |||||||||
| Antibody | WBAntibody00000361 | ||||||||
| WBAntibody00000750 | |||||||||
| WBAntibody00001262 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (173) | |||||||||
| Interaction (129) | |||||||||
| Map_info | Map | X | Position | -18.7759 | Error | 0.006952 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | mnDp69 | |||||||
| meDf3 | |||||||||
| meDf5 | |||||||||
| mnDp52 | |||||||||
| yDp13 | |||||||||
| yDp15 | |||||||||
| meDf2 | |||||||||
| meDf6 | |||||||||
| Positive_clone | C04D1 | ||||||||
| K03E6 | Author_evidence | (rescues when | |||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Negative | Negative_clone | C55D6 | |||||||
| T17A11 | |||||||||
| Mapping_data | 2_point (12) | ||||||||
| Multi_point (38) | |||||||||
| Pos_neg_data (46) | |||||||||
| Landmark_gene | |||||||||
| Reference (106) | |||||||||
| Method | Gene |
