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WormBase Tree Display for Gene: WBGene00006741

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Name Class

WBGene00006741SMapS_parentSequenceK03E6
IdentityVersion1
NameCGC_nameunc-1Person_evidenceWBPerson261
Sequence_nameK03E6.5
Molecular_nameK03E6.5a
K03E6.5a.1
CE28585
K03E6.5b
CE42275
K03E6.5b.1
Other_nameunc-102
CELE_K03E6.5Accession_evidenceNDBBX284606
Public_nameunc-1
DB_infoDatabaseAceViewgeneXB678
WormQTLgeneWBGene00006741
WormFluxgeneWBGene00006741
NDBlocus_tagCELE_K03E6.5
PanthergeneCAEEL|WormBase=WBGene00006741|UniProtKB=Q21190
familyPTHR10264
NCBIgene180458
RefSeqproteinNM_001129690.5
NM_075801.7
SwissProtUniProtAccQ21190
TrEMBLUniProtAccG5ED08
UniProt_GCRPUniProtAccQ21190
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:41WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Allele (97)
Legacy_informationlass 1 (loss-of-function) e719 : putative null recessive kinker. ES3 NA (recessive) > 10. unc-1 Class 3 (neomorph/antimorph) e94sd (former reference allele) : recessive kinker e94/+ is weak coiler ES2 ME2; e1598dm (pka unc-102) : both homozygote and e1598/+ are strong coilers resistant to aldicarb (cholinesterase inhibitor); intragenic revertants of e1598 have Class 1 phenotype. ES3 ME0. NA (dominant) > 8. Complex complementation among unc-1 alleles.
See unc-1.
See also e1598, e2380, e2381, n494, n496, n774, n775, n779, n782, n783, n784, n1166, n1167, n1200, n1201, n1202, n1203, n1204, n1205, n1206, n1207, n1208, n1209
[C.elegansII] e719 : recessive kinker, putative null. Suppresses anaesthetic hypersensitivity of unc-79 and unc-80 mutants. ES3 ME1. OA>10(recessive): e50, e68, e114 (anomalous allele, transdominant suppressor of n494sd), etc. Also neomorph/antimorph gf alleles: e94sd (former reference allele, recessive kinker; e94/+ is weak coiler. ES2 ME2), e1598dm (pka unc-102, both homozygote and e1598/+ are strong Ric coilers; intragenic revertants of e1598 resemble e719. ES3 ME0). OA>8 (dominant and semidominant);n496, n775 (strongly dominant), n494 (weaklysemidominant), etc. Complex complementation among unc-1 alleles. [Park and Horvitz 1986a; Morgan and Sedensky 1994; CW]
Strain (37)
RNASeq_FPKM (74)
GO_annotation (15)
Ortholog (29)
ParalogWBGene00003166Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006063Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006064Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006065Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006066Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006067Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006068Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006761Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006061Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionunc-1 encodes one of ten C. elegans stomatin-like proteins (SLPs) homologous to human erythrocyte surface protein band 7.2 (EPB72/Stomatin) (OMIM:133090; deficient in stomatocytosis); UNC-1 activity regulates electrical coupling between body wall muscles and is required in neurons for normal locomotion; unc-1 is also required for anesthetic sensitivity; an unc-1 promoter::DsRED2 fusion is expressed in body wall muscle, vulval muscle, anal-depressor muscle, stomatointestinal muscle, nearly all ventral cord motor neurons and the nerve ring; in neurons and body wall muscle, UNC-1 colocalizes with UNC-9, an innexin, at intercellular junctions; unc-24, which also encodes a stomatin homolog, is epistatic to unc-1 and required for UNC-1 localization in the nerve ring.Paper_evidenceWBPaper00000031
WBPaper00004649
WBPaper00030879
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated18 Jul 2008 00:00:00
Automated_descriptionEnables ion channel regulator activity. Involved in positive regulation of cell communication by electrical coupling and response to xenobiotic stimulus. Located in axon and gap junction. Expressed in several structures, including enteric muscle; ganglia; head neurons; somatic nervous system; and vulval muscle.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS290 version of WormBase
Date_last_updated11 Sep 2023 00:00:00
Molecular_infoCorresponding_CDSK03E6.5a
K03E6.5b
Corresponding_CDS_historyK03E6.5:wp188
Corresponding_transcriptK03E6.5a.1
K03E6.5b.1
Other_sequence (59)
Associated_featureWBsf670099
WBsf1003931
WBsf1003932
WBsf1022206
WBsf1022207
WBsf1022208
WBsf236994
WBsf236995
WBsf236996
Experimental_infoRNAi_resultWBRNAi00103042Inferred_automaticallyRNAi_primary
WBRNAi00049837Inferred_automaticallyRNAi_primary
Expr_patternExpr527
Expr887
Expr3407
Expr4819
Expr1022667
Expr1032816
Expr1153550
Expr2017854
Expr2035990
Drives_constructWBCnstr00012258
WBCnstr00012259
WBCnstr00012423
WBCnstr00014590
WBCnstr00019884
WBCnstr00034181
Construct_productWBCnstr00012423
WBCnstr00023065
WBCnstr00034181
WBCnstr00042106
Antibody (3)
Microarray_results (22)
Expression_cluster (191)
Interaction (129)
Map_infoMapXPosition-18.7759Error0.006952
Well_ordered
PositiveInside_rearrmnDp69
meDf3
meDf5
mnDp52
yDp13
yDp15
meDf2
meDf6
Positive_cloneC04D1
K03E6Author_evidence(rescues when
Inferred_automaticallyFrom sequence, transcript, pseudogene data
NegativeNegative_cloneC55D6
T17A11
Mapping_data2_point (12)
Multi_point (38)
Pos_neg_data (46)
Landmark_gene
Reference (109)
MethodGene