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WormBase Tree Display for Gene: WBGene00006741

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Name Class

WBGene00006741SMapS_parentSequenceK03E6
IdentityVersion1
NameCGC_nameunc-1Person_evidenceWBPerson261
Sequence_nameK03E6.5
Molecular_nameK03E6.5a
K03E6.5a.1
CE28585
K03E6.5b
CE42275
K03E6.5b.1
Other_nameunc-102
CELE_K03E6.5Accession_evidenceNDBBX284606
Public_nameunc-1
DB_infoDatabaseAceViewgeneXB678
WormQTLgeneWBGene00006741
WormFluxgeneWBGene00006741
NDBlocus_tagCELE_K03E6.5
PanthergeneCAEEL|WormBase=WBGene00006741|UniProtKB=Q21190
familyPTHR10264
NCBIgene180458
RefSeqproteinNM_001129690.5
NM_075801.7
SwissProtUniProtAccQ21190
TrEMBLUniProtAccG5ED08
UniProt_GCRPUniProtAccQ21190
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:41WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Allele (97)
Legacy_informationlass 1 (loss-of-function) e719 : putative null recessive kinker. ES3 NA (recessive) > 10. unc-1 Class 3 (neomorph/antimorph) e94sd (former reference allele) : recessive kinker e94/+ is weak coiler ES2 ME2; e1598dm (pka unc-102) : both homozygote and e1598/+ are strong coilers resistant to aldicarb (cholinesterase inhibitor); intragenic revertants of e1598 have Class 1 phenotype. ES3 ME0. NA (dominant) > 8. Complex complementation among unc-1 alleles.
See unc-1.
See also e1598, e2380, e2381, n494, n496, n774, n775, n779, n782, n783, n784, n1166, n1167, n1200, n1201, n1202, n1203, n1204, n1205, n1206, n1207, n1208, n1209
[C.elegansII] e719 : recessive kinker, putative null. Suppresses anaesthetic hypersensitivity of unc-79 and unc-80 mutants. ES3 ME1. OA>10(recessive): e50, e68, e114 (anomalous allele, transdominant suppressor of n494sd), etc. Also neomorph/antimorph gf alleles: e94sd (former reference allele, recessive kinker; e94/+ is weak coiler. ES2 ME2), e1598dm (pka unc-102, both homozygote and e1598/+ are strong Ric coilers; intragenic revertants of e1598 resemble e719. ES3 ME0). OA>8 (dominant and semidominant);n496, n775 (strongly dominant), n494 (weaklysemidominant), etc. Complex complementation among unc-1 alleles. [Park and Horvitz 1986a; Morgan and Sedensky 1994; CW]
Strain (37)
RNASeq_FPKM (74)
GO_annotation (15)
Ortholog (29)
ParalogWBGene00003166Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006063Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006064Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006065Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006066Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006067Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006068Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006761Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006061Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionunc-1 encodes one of ten C. elegans stomatin-like proteins (SLPs) homologous to human erythrocyte surface protein band 7.2 (EPB72/Stomatin) (OMIM:133090; deficient in stomatocytosis); UNC-1 activity regulates electrical coupling between body wall muscles and is required in neurons for normal locomotion; unc-1 is also required for anesthetic sensitivity; an unc-1 promoter::DsRED2 fusion is expressed in body wall muscle, vulval muscle, anal-depressor muscle, stomatointestinal muscle, nearly all ventral cord motor neurons and the nerve ring; in neurons and body wall muscle, UNC-1 colocalizes with UNC-9, an innexin, at intercellular junctions; unc-24, which also encodes a stomatin homolog, is epistatic to unc-1 and required for UNC-1 localization in the nerve ring.Paper_evidenceWBPaper00000031
WBPaper00004649
WBPaper00030879
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated18 Jul 2008 00:00:00
Automated_descriptionEnables ion channel regulator activity. Involved in positive regulation of cell communication by electrical coupling and response to xenobiotic stimulus. Located in axon and gap junction. Expressed in several structures, including enteric muscle; ganglia; head neurons; somatic nervous system; and vulval muscle.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS290 version of WormBase
Date_last_updated11 Sep 2023 00:00:00
Molecular_infoCorresponding_CDSK03E6.5a
K03E6.5b
Corresponding_CDS_historyK03E6.5:wp188
Corresponding_transcriptK03E6.5a.1
K03E6.5b.1
Other_sequence (59)
Associated_featureWBsf670099
WBsf1003931
WBsf1003932
WBsf1022206
WBsf1022207
WBsf1022208
WBsf236994
WBsf236995
WBsf236996
Experimental_infoRNAi_resultWBRNAi00103042Inferred_automaticallyRNAi_primary
WBRNAi00049837Inferred_automaticallyRNAi_primary
Expr_patternExpr527
Expr887
Expr3407
Expr4819
Expr1022667
Expr1032816
Expr1153550
Expr2017854
Expr2035990
Drives_constructWBCnstr00012258
WBCnstr00012259
WBCnstr00012423
WBCnstr00014590
WBCnstr00019884
WBCnstr00034181
Construct_productWBCnstr00012423
WBCnstr00023065
WBCnstr00034181
WBCnstr00042106
AntibodyWBAntibody00000361
WBAntibody00000750
WBAntibody00001262
Microarray_results (22)
Expression_clusterWBPaper00005700:transmembrane_protein
WBPaper00032425:up_in_zfp-1
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00037950:A-class-motor-neurons_larva_enriched
WBPaper00037950:all-neurons_larva_enriched
WBPaper00037950:dopaminergic-neurons_larva_enriched
WBPaper00037950:glr-1(+)-neurons_larva_enriched
WBPaper00037950:PVD-OLL-neurons_larva_enriched
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00044037:eat-2_upregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044656:tatn-1(qd182)_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00045974:NSM_enriched_totalRNA_RNAseq
WBPaper00046497:B.thuringiensis_upregulated_protein
WBPaper00046795:starvation_upregulated
WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
WBPaper00047131:daf-2(e1370)_upregulated_N2-background
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_enriched
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
WBPaper00049920:Glucose-Diet_upregulated_N2
WBPaper00050053:muscle_enriched_Day4
WBPaper00050332:skn-1(RNAi)_downregulated
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:seam_expressed
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
WBPaper00051437:Cit-SPIONs_downregulated
WBPaper00051461:pig-1(gm344)_downregulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053388:dauer_regulated_Cluster4
WBPaper00053615:SMO-1_target
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055060:flr-1(RNAi)_upregulated
WBPaper00055103:thoc-5(wy822)_upregulated
WBPaper00055354:eat-2(ad1116)_upregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055482:Tunicamycin_downregulated
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00055648:male-tail_expressed
WBPaper00055827:pfd-6(gk493446)_downregulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056826:hmc_biased
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058691:cfp-1(tm6369)_upregulated
WBPaper00058691:set-2(bn129)_upregulated
WBPaper00058691:sin-3(tm1276)_upregulated
WBPaper00058711:skn-1(lax188)_upregulated
WBPaper00058948:PA14_downregulated
WBPaper00059027:neuron-synapses_depleted
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059421:daf-3(mgDf90)_downregulated
WBPaper00059471:EGL-43_interacting
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059763:neuron_expressed
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061210:huIs179_upregulated
WBPaper00061274:hypergravity_10xg_upregulated
WBPaper00061274:microgravity_downregulated
WBPaper00061340:AIB
WBPaper00061340:AIM
WBPaper00061340:AIZ
WBPaper00061340:ALN
WBPaper00061340:AVB
WBPaper00061340:AVD
WBPaper00061340:AVG
WBPaper00061340:AVL
WBPaper00061340:DA
WBPaper00061340:DA_DB
WBPaper00061340:DB
WBPaper00061340:DD
WBPaper00061340:DVA
WBPaper00061340:DVC
WBPaper00061340:FLP
WBPaper00061340:hmc
WBPaper00061340:IL1
WBPaper00061340:mu_int_mu_anal
WBPaper00061340:mu_sph
WBPaper00061340:OLL
WBPaper00061340:PVP
WBPaper00061340:PVT
WBPaper00061340:RIA
WBPaper00061340:RIB
WBPaper00061340:RIC
WBPaper00061340:RIM
WBPaper00061340:RMD
WBPaper00061340:RME
WBPaper00061340:SMB
WBPaper00061340:SMD
WBPaper00061405:S.aureus_downregulated_starvation
WBPaper00061424:Diet_MYb120_upregulated
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061527:syd-1_2945-unc-41_2170
WBPaper00061651:AIZ_enriched
WBPaper00061651:DA_enriched
WBPaper00061651:DB01_enriched
WBPaper00061651:DB_enriched
WBPaper00061651:I3_enriched
WBPaper00061651:I4_enriched
WBPaper00061651:M2_enriched
WBPaper00061651:NSM_enriched
WBPaper00061651:PDA_enriched
WBPaper00061651:PDB_enriched
WBPaper00061651:RIG_enriched
WBPaper00061651:VA12_enriched
WBPaper00061651:VB01_enriched
WBPaper00061651:VB_enriched
WBPaper00062103:neuron_enriched
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062554:MAGU-2_interacting
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064156:lipl-4(overexpress)_upregulated
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064721:fasn-1(g14)_downregulated_starved
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065158:25C_vs_15C_upregulated_AFD
cgc4386_cluster_6_5
cgc4489_group_14
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Enriched_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00030839:Embryo_A_Class
WBPaper00030839:Embryo_Pan_Neuronal
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00031003:hlh_1_enriched
WBPaper00031532:Larva_Pan_Neuronal_Enriched
WBPaper00035588:alg-1(-)_upregulated
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00036123:Atrazine_regulated
WBPaper00036286:Pattern_C
WBPaper00037695:WC_5-day
WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040876:mir-35_downregulated
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:control_vs_UVC-exposed_3h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
WBPaper00042274:tbx-2(bx59)_upregulated
WBPaper00045673:colistin_upregulated
WBPaper00057098:SiO2-nanoparticles_upregulated
Interaction (129)
Map_infoMapXPosition-18.7759Error0.006952
Well_ordered
PositiveInside_rearrmnDp69
meDf3
meDf5
mnDp52
yDp13
yDp15
meDf2
meDf6
Positive_cloneC04D1
K03E6Author_evidence(rescues when
Inferred_automaticallyFrom sequence, transcript, pseudogene data
NegativeNegative_cloneC55D6
T17A11
Mapping_data2_point (12)
Multi_point (38)
Pos_neg_data (46)
Landmark_gene
Reference (109)
MethodGene