WormBase Tree Display for Gene: WBGene00003735

WBGene00003735 SMap: S_parent: Sequence: Y18D10A
  Identity: Version: 1
    Name: CGC_name: nhx-8
      Sequence_name: Y18D10A.6
      Molecular_name: Y18D10A.6a
        Y18D10A.6a.1
        CE31092
        Y18D10A.6b
        CE31093
        Y18D10A.6b.1
      Other_name: CELE_Y18D10A.6 Accession_evidence: NDB BX284601
      Public_name: nhx-8
    DB_info: Database: AceView gene 1N425
        WormQTL gene WBGene00003735
        WormFlux gene WBGene00003735
        NDB locus_tag CELE_Y18D10A.6
        Panther gene CAEEL|WormBase=WBGene00003735|UniProtKB=G5EBN7
          family PTHR10110
        NCBI gene 189474
        RefSeq protein NM_001026557.4
            NM_001026558.5
        TREEFAM TREEFAM_ID TF354313
        TrEMBL UniProtAcc G5EBN7
            G5EFN1
        UniProt_GCRP UniProtAcc G5EBN7
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nhx
    Allele (184)
    Strain: WBStrain00002334
      WBStrain00002723
      WBStrain00031483
    RNASeq_FPKM (74)
    GO_annotation (21)
    Ortholog (34)
    Paralog: WBGene00003729 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003730 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003731 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003732 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003733 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003734 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003736 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003943 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: nhx-8 encodes two isoforms of a sodium/proton exchanger expressed intracellularly within hypodermal seam cells, pharyngeal muscles, pharyngeal-intestinal and intestinal-rectal valve cells, and vulval cells; nhx-8 has no obvious phenotype in mass RNAi screens; NHX-8 is thought to prevent intracellular acidification by catalysing the electroneutral exchange of vesicular sodium for an intracellular proton. Paper_evidence: WBPaper00004402
            WBPaper00005421
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport and regulation of intracellular pH. Predicted to be located in membrane. Expressed in several structures, including hypodermis; pharyngeal muscle cell; pharyngeal-intestinal valve; rectal valve cell; and vulva. Is an ortholog of human SLC9A8 (solute carrier family 9 member A8). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: Y18D10A.6a
      Y18D10A.6b
    Corresponding_CDS_history: Y18D10A.6:wp80
    Corresponding_transcript: Y18D10A.6a.1
      Y18D10A.6b.1
    Other_sequence (44)
    Associated_feature: WBsf643780
      WBsf656987
      WBsf218643
  Experimental_info: RNAi_result: WBRNAi00116504 Inferred_automatically: RNAi_primary
      WBRNAi00055620 Inferred_automatically: RNAi_primary
      WBRNAi00004546 Inferred_automatically: RNAi_primary
    Expr_pattern (13)
    Drives_construct: WBCnstr00003003
      WBCnstr00003255
      WBCnstr00004498
      WBCnstr00010716
      WBCnstr00010727
    Construct_product: WBCnstr00010727
    Microarray_results (23)
    Expression_cluster: WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00033065:isp-1-1(qm150)_downregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_embryo_enriched
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Spermatogenic
      WBPaper00045774:clk-1_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00048988:neuron_expressed
      WBPaper00049001:EVN_enriched
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055103:thoc-5(wy822)_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055648:sperm_expressed
      WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057288:iff-1(RNAi)_upregulated_transcript
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058691:sin-3(tm1276)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059440:GLP-1_represseded
      WBPaper00059440:LAG-1_repressed_48hr-auxin
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00061007:HB101_upregulated
      WBPaper00061203:let-418(n3536)_downregulated
      WBPaper00061527:176662_at-Y53F4B.16
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_upregulated
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064505:tamoxifen_downregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00066085:sin-3(tm1276)_upregulated
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
    Interaction (32)
  Map_info: Map: I Position: 14.1387 Error: 0.010006
    Positive: Positive_clone: Y18D10A Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4534
        5086
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
    WBPaper00066025
  Remark: Sequence connection from [Nehrke K, Melvin J]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
    nxh-2 nxh-3 nxh-4 nxh-5 nxh-6 nxh-7 nxh-8 nxh-9 published in cgc5421 actually refer to nhx genes CGC_data_submission
  Method: Gene