WormBase Tree Display for Gene: WBGene00001330

WBGene00001330 SMap: S_parent: Sequence: Y57G11C
  Identity: Version: 1
    Name: CGC_name: eps-8 Person_evidence: WBPerson52
      Sequence_name: Y57G11C.24
      Molecular_name (36)
      Other_name: gei-19 CGC_data_submission
        CELE_Y57G11C.24 Accession_evidence: NDB BX284604
      Public_name: eps-8
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: eps
    Allele (382)
    Strain: WBStrain00003266
      WBStrain00031465
      WBStrain00005395
    RNASeq_FPKM (74)
    GO_annotation (32)
    Ortholog (53)
    Structured_description: Concise_description: eps-8 is encodes a cell signaling adaptor protein that contains and N-terminal PTB domain, and C-terminal SH3 and actin-binding domains; EPS-8 is essential for epidermal and intestinal cells morphogenesis; eps-8 is also involved in trafficking of the LET-23 EGF receptor during vulval development; EPS-8 physically interacts with the ankyrin repeat protein VAB-19 and demonstrates a novel actin barbed-end-capping activity; EPS-8 is expressed throughout development and localizes to sites of cell-matrix attachment and to the apical side of polarized cells. Paper_evidence: WBPaper00004651
            WBPaper00005194
            WBPaper00005654
            WBPaper00006395
            WBPaper00032444
            WBPaper00027626
            WBPaper00024614
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 29 Jan 2012 00:00:00
      Automated_description: Enables actin filament binding activity. Involved in several processes, including anatomical structure morphogenesis; barbed-end actin filament capping; and supramolecular fiber organization. Located in apical part of cell; brush border; and hemidesmosome. Expressed in several structures, including P3.pa; P3.pp; P5.ppp; P7.paa; and P9.p. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102; autosomal recessive nonsyndromic deafness 106; and hypotrichosis 5. Is an ortholog of human EPS8L1 (EPS8 signaling adaptor L1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (3)
  Molecular_info: Corresponding_CDS (12)
    Corresponding_CDS_history: Y57G11C.24a:wp107
      Y57G11C.24a:wp151
      Y57G11C.24b:wp151
      Y57G11C.24c:wp107
      Y57G11C.24c:wp151
      Y57G11C.24d:wp151
      Y57G11C.24e:wp151
    Corresponding_transcript (12)
    Other_sequence (45)
    Associated_feature (20)
  Experimental_info: RNAi_result (27)
    Expr_pattern (12)
    Drives_construct: WBCnstr00003741
      WBCnstr00005193
      WBCnstr00005431
      WBCnstr00011220
    Construct_product: WBCnstr00005192
      WBCnstr00005432
      WBCnstr00011220
    Antibody: WBAntibody00000805
      WBAntibody00000806
    Microarray_results (64)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032031:DConiospora_downregulated_cDNA_24h
      WBPaper00035073:mitochondria_protein
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040990:PA14_upregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044656:tatn-1(qd182)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_downregulated_Day5
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045401:N.parisii_30h_downregulated
      WBPaper00045417:128Q-huntingtin_downreglated
      WBPaper00046121:endoderm_unique
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00046795:starvation_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049626:UNC-75_target
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050015:ifg-1(RNAi)_upregulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050514:CEBP-1_interacting
      WBPaper00050599:nicotine(0.01mM)_upregulated
      WBPaper00050599:nicotine(1mM)_upregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051352:Long-Term-Association-Memory_upregulated
      WBPaper00051555:atm-1(gk186)_regulated_protein
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056161:hermaphrodite_enriched_siRNA
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
      WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059605:MUT-16_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059895:wounding_upregulated
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060278:atp-2(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:mc1
      WBPaper00061340:mc2
      WBPaper00061340:Pharyngeal_marginal_cell
      WBPaper00061340:pm3_pm4_pm5
      WBPaper00061340:pm7
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:ifd-1-ifp-1
      WBPaper00061527:ldb-1_2877-scd-1_3086
      WBPaper00061527:saeg-1_18803-mpz-2_15880
      WBPaper00061527:sre-33-ZK1025.1_8337
      WBPaper00061818:ELKS-1_interacting
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064315:mes-3(bn199)_upregulated_PGCs
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064315:mes-4(bn73)_upregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065841:3_4
      WBPaper00065841:30_4
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
      WBPaper00066232:hsf-1(RNAi)_upregulated_WT
      cgc4386_cluster_3_6
      WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00031832:slr-2_regulated
      WBPaper00034661:AgNPs_downregulated
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00037695:LD_DD_6-day
      WBPaper00038060:SUMO-1_downregulated
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
      WBPaper00040821:Au-NP_regulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040963:Q50_down
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00040963:TA300_up
      WBPaper00040985:AIN-2_L4_intestine
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(186_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MDE
      [cgc5767]:expression_class_MD_pd(23_min)
      [cgc5767]:expression_class_ME
    SAGE_tag: SAGE:caacaacaac Strand: Sense
        Unambiguously_mapped
      SAGE:gtccaggtgg Strand: Antisense
      SAGE:ttcccggcgg Strand: Antisense
      SAGE:caacaacaacaacagca Strand: Sense
        Unambiguously_mapped
    Interaction (109)
  Map_info: Map: IV Position: 12.6052 Error: 0.00069
    Positive: Positive_clone: Y57G11C Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4235
        4290
    Pseudo_map_position
  Reference (24)
  Remark: gei-19 has been merged into the eps-8 gene following advice from the CGC [krb 030902]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene