[C.elegansII] mn29 : late larval lethal. OA2: b285 (Mel), mn182. [Sigurdson et al. 1984; Kemphues et al. 1988]
[Lieb JD] pka let-29. Encodes 1245 aa XCAP-E homolog. mn29 is G35S, b285 is E64K. Predicted gene R06F6.10 + M106.1 (mix-1 spans gap between R06F6 and M106)
The mix-1 gene encodes a homolog of SMC2 involved in chromosome segregation, X-chromosome gene regulation, and repression of X-linked genes during dosage compensation.
Predicted to enable chromatin binding activity. Involved in several processes, including dosage compensation by hypoactivation of X chromosome; mitotic chromosome condensation; and positive regulation of nematode male tail tip morphogenesis. Located in chromosome, centromeric region and condensed chromosome. Part of dosage compensation complex. Expressed in AB. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Is an ortholog of human SMC2 (structural maintenance of chromosomes 2).