WormBase Tree Display for Expr_pattern: Expr1443
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| Expr1443 | Expression_of | Gene | WBGene00003367 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00003367 | |||
| Expression_data | Life_stage | WBls:0000003 | ||
| Anatomy_term | WBbt:0004015 | Certain | ||
| GO_term | GO:0005694 | |||
| Subcellular_localization | In young embryos, prior to the initiation of dosage compensation (30 cells), MIX-1 is localized to all chromosomes during mitosis. In older wild-type XX embryos that have activated dosage compensation, MIX-1 is localized to X in interphase cells; it then appears to accumulate to a higher level in mitotic cells, where it associates with all chromosomes. | |||
| Type | Antibody | MIX-1 antibodies | ||
| Pattern | At 2-cell embryo, MIX-1 protein can be seen in AB, but not in P1. After mitosis, MIX-1 staining becomes more diffuse and less intense, only to increase in intensity just prior to the next mitosis. This apparent oscillation in MIX-1 protein levels is obscured by the accumulation of MIX-1 protein in the interphase nuclei of embryos (~30-cell stage) undergoing rapid cell divisions. However, at a time after most embryonic cell divisions have occurred, cell cycle regulationof MIX-1 becomes noticeable once again. Mitotic cells exhibitintense MIX-1 staining, and interphase cells exhibit weaker X chromosomespecific staining. | |||
| Picture | WBPicture0000009514 | |||
| WBPicture0000009515 | ||||
| WBPicture0000009517 | ||||
| Remark | No detailed description on cellular expression pattern at later stages. | |||
| mix-1 is previously known as let-29. | ||||
| Reference | WBPaper00002999 | |||
| Antibody_info | WBAntibody00000163 |
