WormBase Tree Display for Gene: WBGene00003096

WBGene00003096 SMap: S_parent: Sequence: C02A12
  Identity: Version: 1
    Name: CGC_name: lys-7 Person_evidence: WBPerson168
      Sequence_name: C02A12.4
      Molecular_name: C02A12.4
        C02A12.4.1
        CE07828
      Other_name: CELE_C02A12.4 Accession_evidence: NDB BX284605
      Public_name: lys-7
    DB_info: Database: AceView gene 5D960
        WormQTL gene WBGene00003096
        WormFlux gene WBGene00003096
        NDB locus_tag CELE_C02A12.4
        Panther gene CAEEL|WormBase=WBGene00003096|UniProtKB=O16202
          family PTHR23208
        NCBI gene 178772
        RefSeq protein NM_071571.9
        SwissProt UniProtAcc O16202
        TREEFAM TREEFAM_ID TF316378
        UniProt_GCRP UniProtAcc O16202
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lys
    Allele (30)
    Strain: WBStrain00031984
      WBStrain00031985
      WBStrain00004711
      WBStrain00004740
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog (20)
    Paralog: WBGene00003090 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00003091 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00003092 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003093 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003094 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003095 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003097 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00003098 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003099 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: lys-7 encodes an enzyme homologous to an antimicrobial lysozyme encoded by the LYS4 gene of the protozoan parasite Entamoeba histolytica; LYS-7 functions in the innate immune response as an antimicrobial enzyme that, by homology, hydrolyzes the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of prokaryotic cell walls; loss of lys-7 activity results in enhanced susceptibility to P. aeruginosa PA14, renders worms susceptible to Cryptococcus neoformans killing, but enhances tolerance to the enteric bacteria Salmonella typhimurium; lys-7 expression is significantly upregulated in response to infection with the Gram-negative bacterium Serratia marcescens; constitutive expression of lys-7 mRNA is detected in the intestine and the intestinal valve cells. Paper_evidence (7)
          Curator_confirmed: WBPerson1843
          Date_last_updated: 19 Feb 2014 00:00:00
      Automated_description: Involved in defense response to other organism. Expressed in head neurons; intestine; and rectal gland cell. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C02A12.4
    Corresponding_transcript: C02A12.4.1
    Other_sequence: DN190521.1
      Tcol_isotig00444
      Tcol_isotig00441
      EX549286.1
      Oden_isotig23438
      Tcol_isotig04406
      EX549913.1
      Tcol_isotig03848
      EX550124.1
      EX542109.1
      ES412762.1
      Tcol_isotig00442
      Name_isotig00050
      EX565189.1
      EW744150.1
      Oden_isotig21357
      ES408766.1
      Name_isotig00048
      ACC05551_1
      AYC03406_1
      EY464688.1
      AAC00278_1
      Tcol_isotig07639
      EX567112.1
      EX010474.1
      Tcol_isotig07134
      GR978672.1
      EX544286.1
      PSC02122_2
      EX541769.1
      Hbac_isotig00181
      EX008359.1
      PPC05226_1
      EX552459.1
      Tcol_isotig04815
      Tcol_isotig16616
      HCC01129_1
      Tcol_isotig23831
      Tcol_isotig07135
      GW408612.1
      BG467910.1
      Oden_isotig00196
      Tcol_isotig15178
      Tcol_isotig15216
      Tcol_isotig07136
      Tcol_isotig06855
      Tcol_isotig03850
      HCC01783_1
      Tcol_isotig04407
      SC00791
      EW744029.1
      EY459527.1
      Acan_isotig04441
      EW743583.1
      Tcol_isotig00439
      HBC18280_1
      EX557069.1
      Tcol_isotig06856
      EX541526.1
      EW742446.1
      Tcol_isotig04405
      Tcol_isotig03847
      Tcol_isotig00440
      Oden_isotig11542
      Tcol_isotig04404
      AE03268
      Tcol_isotig04816
      ES743490.1
      EX914144.1
      HC03448
      Tcir_isotig15602
      EX914079.1
      HC05901
      Oden_isotig11541
      Tcol_isotig13360
      EX014589.1
      EX558320.1
      PPC00637_1
      Oden_isotig24248
      HBC00499_3
      Name_isotig00049
      Acan_isotig12908
      Acan_isotig04440
      EX540040.1
    Associated_feature: WBsf019148
      WBsf019149
      WBsf652532
      WBsf233493
      WBsf233494
  Experimental_info: RNAi_result (21)
    Expr_pattern: Expr1973
      Expr4716
      Expr10716
      Expr1018008
      Expr1143497
      Expr2013318
      Expr2031549
    Drives_construct: WBCnstr00009965
      WBCnstr00012193
      WBCnstr00015892
      WBCnstr00017492
      WBCnstr00036232
      WBCnstr00041439
    Construct_product: WBCnstr00009965
      WBCnstr00012193
      WBCnstr00036232
    Microarray_results (18)
    Expression_cluster (437)
    Interaction (200)
    WBProcess: WBbiopr:00000008
      WBbiopr:00000039
  Map_info: Map: V Position: -10.8998 Error: 0.024633
    Positive: Positive_clone: C02A12 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data (2)
    Pseudo_map_position
  Reference: WBPaper00005382
    WBPaper00005569
    WBPaper00005976
    WBPaper00006302
    WBPaper00006437
    WBPaper00024209
    WBPaper00025180
    WBPaper00027295
    WBPaper00027722
    WBPaper00029438
    WBPaper00031095
    WBPaper00031802
    WBPaper00032232
    WBPaper00032276
    WBPaper00032331
    WBPaper00032370
    WBPaper00033781
    WBPaper00036474
    WBPaper00036653
    WBPaper00037128
    WBPaper00038100
    WBPaper00038223
    WBPaper00038503
    WBPaper00038506
    WBPaper00040118
    WBPaper00040174
    WBPaper00040209
    WBPaper00040287
    WBPaper00040389
    WBPaper00040549
    WBPaper00041211
    WBPaper00041339
    WBPaper00041525
    WBPaper00042276
    WBPaper00042367
    WBPaper00043135
    WBPaper00044718
    WBPaper00045438
    WBPaper00046040
    WBPaper00047109
    WBPaper00048424
    WBPaper00050428
    WBPaper00053417
    WBPaper00055320
    WBPaper00056410
    WBPaper00057299
    WBPaper00057414
    WBPaper00058665
    WBPaper00059715
    WBPaper00061133
    WBPaper00061774
    WBPaper00062392
    WBPaper00064183
    WBPaper00064229
    WBPaper00064255
    WBPaper00064370
    WBPaper00064543
    WBPaper00064639
    WBPaper00064841
    WBPaper00064950
    WBPaper00065026
    WBPaper00065034
    WBPaper00065681
    WBPaper00065718
    WBPaper00066310
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene