WormBase Tree Display for Gene: WBGene00003097
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| WBGene00003097 | SMap | S_parent | Sequence | C17G10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lys-8 | Person_evidence | WBPerson168 | |||||
| Sequence_name | C17G10.5 | ||||||||
| Molecular_name | C17G10.5 | ||||||||
| C17G10.5.1 | |||||||||
| CE06846 | |||||||||
| Other_name | CELE_C17G10.5 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | lys-8 | ||||||||
| DB_info | Database | AceView | gene | 2F877 | |||||
| WormQTL | gene | WBGene00003097 | |||||||
| WormFlux | gene | WBGene00003097 | |||||||
| NDB | locus_tag | CELE_C17G10.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003097|UniProtKB=Q09975 | |||||||
| family | PTHR23208 | ||||||||
| NCBI | gene | 173944 | |||||||
| RefSeq | protein | NM_062682.6 | |||||||
| TREEFAM | TREEFAM_ID | TF316378 | |||||||
| TrEMBL | UniProtAcc | Q09975 | |||||||
| UniProt_GCRP | UniProtAcc | Q09975 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lys | ||||||||
| Allele (20) | |||||||||
| Strain | WBStrain00033203 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00055571 | ||||||||
| 00055572 | |||||||||
| 00055573 | |||||||||
| 00055574 | |||||||||
| 00055575 | |||||||||
| Ortholog (35) | |||||||||
| Paralog | WBGene00003090 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003091 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003092 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003093 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003094 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003095 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003096 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003099 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003098 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | lys-8 encodes a putative lysozyme required for normal longevity,probably because it prevents killing of C. elegans by bacteria infectingits gut; LYS-8 is expressed in intestine up to the terminal bulb of thepharynx, as well as in g1 and g2 pharyngeal gland cells; LYS-8expression is induced by infection with Serratia marcescens, Pseudomonasaeruginosa, or (weakly) by Microbacterium nematophilum; LYS-8 expressionis promoted by DBL-1, TIR-1 and NSY-1; lys-8 transcripts are increasedby both DBL-1 and SMA-2 (though not strongly affected by LON-2), perhapsreflecting a general role of the DBL-1 signalling pathway in activatingintestinal genes and susceptibility of dbl-1 mutants to infection; lys-8transcripts are repressed by DAF-2 (and thus presumably increased byDAF-16), and lys-8(RNAi) animals display reduced lifespan; induction ofLSY-8 by any of three different Gram-negative bacteria (E. coli, S.marcescens, or P. aeruginosa) requires DAF-16, DBL-1, and NSY-1; LSY-8and its paralogs (LYS-1 to -7 and LYS-10) are more similar to lysozymesfrom the amoeboid protozoon Entamoeba histolytica than to more familiarones from vertebrates. | Paper_evidence | WBPaper00003859 | |||||
| WBPaper00005382 | |||||||||
| WBPaper00005976 | |||||||||
| WBPaper00027722 | |||||||||
| WBPaper00029438 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 01 Jun 2007 00:00:00 | ||||||||
| Automated_description | Involved in pharyngeal gland morphogenesis. Expressed in neurons and pharyngeal gland cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C17G10.5 | |||||||
| Corresponding_transcript | C17G10.5.1 | ||||||||
| Other_sequence (113) | |||||||||
| Associated_feature | WBsf047528 | ||||||||
| WBsf221304 | |||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Expr999 | ||||||||
| Expr1974 | |||||||||
| Expr2005 | |||||||||
| Expr4717 | |||||||||
| Expr1016614 | |||||||||
| Expr1031466 | |||||||||
| Expr1144884 | |||||||||
| Expr2013319 | |||||||||
| Expr2031550 | |||||||||
| Drives_construct | WBCnstr00012194 | ||||||||
| WBCnstr00036231 | |||||||||
| WBCnstr00042227 | |||||||||
| Construct_product | WBCnstr00012194 | ||||||||
| WBCnstr00036231 | |||||||||
| WBCnstr00042227 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (245) | |||||||||
| Interaction (146) | |||||||||
| WBProcess | WBbiopr:00000039 | ||||||||
| Map_info | Map | II | Position | -1.101 | Error | 0.010782 | |||
| Positive | Positive_clone | C17G10 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (27) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
