| WBGene00000040 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | ZK455 |
| Identity | Version | 1 |
| | Name | CGC_name | aco-1 |
| | | Sequence_name | ZK455.1 |
| | | Molecular_name | ZK455.1 |
| | | | ZK455.1.1 |
| | | | CE03812 |
| | | Other_name | gei-22 | CGC_data_submission |
| | | | CELE_ZK455.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | aco-1 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:19 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | aco |
| | Allele (72) |
| | Strain | WBStrain00023533 |
| | | WBStrain00031712 |
| | RNASeq_FPKM (74) |
| | GO_annotation (20) |
| | Ortholog (38) |
| | Paralog | WBGene00000041 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | aco-1 encodes an aconitase that is homologous to mammalian iron regulatory protein-1 (IRP1); aco-1 activity is required for normal brood sizes and, under iron stress conditions, for normal lifespan and L4-to-adult growth rates; ACO-1 physically interacts with GEX-3; like IRP1, ACO-1 has aconitase activity and is post-translationally regulated by iron, but, unlike IRP1, it lacks RNA-binding activity; aco-1 mRNA levels appear to decrease in response to iron treatment; an ACO-1::GFP fusion protein exhibits cytosolic expression in the hypodermal seam cells and the intestine. | Paper_evidence | WBPaper00004424 |
| | | | | | WBPaper00005194 |
| | | | | | WBPaper00005703 |
| | | | | | WBPaper00024456 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 19 Dec 2012 00:00:00 |
| | | Automated_description | Enables aconitate hydratase activity. Involved in tricarboxylic acid metabolic process. Located in cytosol. Expressed in seam cell. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is an ortholog of human ACO1 (aconitase 1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6115) |
| Molecular_info | Corresponding_CDS | ZK455.1 |
| | Corresponding_transcript | ZK455.1.1 |
| | Other_sequence (60) |
| | Associated_feature | WBsf648536 |
| | | WBsf648537 |
| | | WBsf655212 |
| | | WBsf663332 |
| | | WBsf236371 |
| | | WBsf236372 |
| | | WBsf236373 |
| | | WBsf236374 |
| Experimental_info | RNAi_result | WBRNAi00038297 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00115744 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00059431 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00115745 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00024298 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr434 |
| | | Expr2296 |
| | | Expr2353 |
| | | Expr1021359 |
| | | Expr1030020 |
| | | Expr1162858 |
| | | Expr2009164 |
| | | Expr2027401 |
| | Drives_construct | WBCnstr00010755 |
| | | WBCnstr00010787 |
| | | WBCnstr00018300 |
| | | WBCnstr00037777 |
| | Construct_product (3) |
| | Antibody | WBAntibody00000600 |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00026640:Development_Group_VI |
| | | WBPaper00026640:embryo-to-L1_upregulated |
| | | WBPaper00027022:cnb-1(jh103)_downregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00032976:non_compensated_genes |
| | | WBPaper00037086:biotin_regulated |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:intestine_embryo_enriched |
| | | WBPaper00037950:intestine_embryo_SelectivelyEnriched |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038168:lin-15B(n744)_downregulated |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00043951:insoluble_protein_day16_N2 |
| | | WBPaper00044128:daf-2(e1370)_downregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044746:aging_downregulated_Day5 |
| | | WBPaper00044746:aging_downregulated_HeatShock |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045693:S.flexneri_upregulated |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00045934:wrn-1(gk99)_upregulated |
| | | WBPaper00046303:P.aeruginosa_upregulated_protein |
| | | WBPaper00046337:monosomal_N2_vs_daf-2_upregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046499:AMPK_regulated |
| | | WBPaper00048910:Apoptosis-induced_mRNA-interacting_protein |
| | | WBPaper00048910:mRNA-interacting_protein |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048971:daf-16(mgDf50)_upregulated_L1 |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049920:Glucose-Diet_upregulated_N2 |
| | | WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00050015:ifg-1(RNAi)_upregulated |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050698:DEP-1_interacting |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051039:intestine_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051265:F4_hrde-1(tm1200)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_downregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq |
| | | WBPaper00053321:mes-4(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053615:SMO-1_target |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00053814:15C_downregulated_PY79 |
| | | WBPaper00054192:cold-shock_downregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055482:Tunicamycin_downregulated |
| | | WBPaper00055827:pfd-6(gk493446)_downregulated |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_20C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056275:P.aeruginosa_downregulated |
| | | WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056809:smn-1(ok355)_downregulated |
| | | WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium |
| | | WBPaper00057288:Cold_downregulated_protein |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:set-2(bn129)_downregulated |
| | | WBPaper00058725:sftb-1(cer6)_downregulated |
| | | WBPaper00059253:sucrose_stearic-acid_upregulated |
| | | WBPaper00059253:sucrose_upregulated |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_protein |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059895:wounding_downregulated |
| | | WBPaper00059987:Wounding_downregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060871:M.humicola-extract_1h_regulated |
| | | WBPaper00060871:M.humicola-infection_48h_regulated |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061340:G2_and_W_blasts |
| | | WBPaper00061340:hyp7_AB_lineage |
| | | WBPaper00061340:hyp7_C_lineage |
| | | WBPaper00061340:T |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061527:dhs-28_22199-acs-14 |
| | | WBPaper00061818:AFD_enriched_protein |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064257:UNG-1_interacting |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-3(bn199)_upregulated_PGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_PGCs |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064494:postdauer_upregulated_AWA |
| | | WBPaper00064637:cox-5B(RNAi)_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064727:daf-2(e1370)_upregulated |
| | | WBPaper00064789:Day3_vs_Day1_downregulated_neuron |
| | | WBPaper00064789:Day6_vs_Day1_downregulated_neuron |
| | | WBPaper00064789:Day12_vs_Day1_downregulated_neuron |
| | | WBPaper00064933:E.coli-binding_secret_protein |
| | | WBPaper00064952:Day10_vs_Day1_downregulated_25C |
| | | WBPaper00064952:Day10_vs_L4_downregulated_20C |
| | | WBPaper00064952:Day10_vs_L4_downregulated_25C |
| | | WBPaper00065086:JU1400_N.ausubeli_regulated |
| | | WBPaper00065086:JU1400_N.ferruginous_regulated |
| | | WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065149:lin-52(n771)_downregulated |
| | | WBPaper00065158:AFD_depleted |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00005124:estrogen_10-5M_regulated |
| | | WBPaper00005124:progesterone_10-7M_regulated |
| | | WBPaper00024393:strongly_regulated_dauer_genes |
| | | WBPaper00025032:cluster_25 |
| | | WBPaper00025099:MA_specific |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00030985:Enterococcus_faecalis_upregulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00035873:osm-8_regulated |
| | | WBPaper00036286:Pattern_C |
| | | WBPaper00036383:ash-2_Day8_regulated |
| | | WBPaper00037695:LD_3-day |
| | | WBPaper00038231:Cry5B_1.5-fold_downregulated |
| | | WBPaper00038231:Cry5B_2-fold_downregulated |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_aging |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00041002:HF_3d_0.2mM_Up |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041207:CE_dauer_down |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041906:I-3690_vs_OP50_3d |
| | | WBPaper00041960:daf-16_fasting_upregulated |
| | | WBPaper00041960:jun-1_fasting_upregulated |
| | | WBPaper00041960:kgb-1_fasting_upregulated |
| | | WBPaper00041960:N2_fasting_upregulated |
| | | WBPaper00041960:N2_fasting_upregulated_9hto12h |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00044091:Bpseudomallei_repressed_12h |
| | | WBPaper00045960:L1-L4-lethargus_downregulated |
| | | WBPaper00045960:L4-lethargus_downregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | [cgc5767]:cluster_2 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(101_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | Interaction (90) |
| Map_info | Map | X | Position | 3.01054 | Error | 0.014051 |
| | Positive | Positive_clone | ZK455 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4663 |
| | | | 5397 |
| | | | 5493 |
| | Pseudo_map_position |
| Reference (21) |
| Remark | gei-22 becomes an other name for this gene, main name is aco-1 [JAH][011204 ck1] |
| | Sequence connection from [Qadota H, Kaibuchi K] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
