WormBase Tree Display for Gene: WBGene00002051

WBGene00002051 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: ifa-3 Person_evidence: WBPerson105
            WBPerson293
      Sequence_name: F52E10.5
      Molecular_name: F52E10.5
        F52E10.5.1
        CE34875
      Other_name: Cel IF A3 Accession_evidence: EMBL X70831
        CelIF a3
        A3 Paper_evidence: WBPaper00006137
        CELE_F52E10.5 Accession_evidence: NDB BX284606
      Public_name: ifa-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ifa
    Allele (42)
    Strain: WBStrain00036840
    RNASeq_FPKM (74)
    GO_annotation (12)
    Ortholog (69)
    Paralog: WBGene00002050 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00002053 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00002058 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00002057 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00017327 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00002054 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00002052 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003485 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00002055 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00002056 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003052 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00002067 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: ifa-3 encodes an essential intermediate filament protein that is coexpressed with the essential IF protein IFB-1; IFA-3 is required for survival past early larval stages, correct positioning of excretory canals and body muscles, attachment of cuticle to hypodermis, and locomotion; IFA-3 forms heteropolymeric intermediate filaments in vitro with an equimolar mixture of IFB-1; IFA-3 is expressed in embryonic and larval, but not adult, hypodermis. Paper_evidence: WBPaper00001981
            WBPaper00004761
            WBPaper00006137
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in cellular localization; heterochromatin formation; and nucleus organization. Predicted to be located in nuclear envelope and nuclear lamina. Expressed in hypodermis and ventral cord neurons. Human ortholog(s) of this gene implicated in partial lipodystrophy; primary autosomal recessive microcephaly; and progressive myoclonus epilepsy 9. Is an ortholog of human LMNB2 (lamin B2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111450 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6638)
      DOID:0070296 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6638)
      DOID:0080299 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6638)
  Molecular_info: Corresponding_CDS: F52E10.5
    Corresponding_CDS_history: F52E10.5:wp83
      F52E10.5:wp102
      F52E10.5:wp106
    Corresponding_transcript: F52E10.5.1
    Other_sequence (33)
    Associated_feature: WBsf718810
      WBsf238387
      WBsf238388
  Experimental_info: RNAi_result (16)
    Expr_pattern: Expr1496
      Expr1020134
      Expr1031204
      Expr1151810
      Expr2012677
      Expr2030913
    Drives_construct: WBCnstr00008111
      WBCnstr00036493
    Construct_product: WBCnstr00008111
      WBCnstr00036493
    Microarray_results (16)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00035197:fer-1_downregulated
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_embryo_enriched
      WBPaper00037950:hypodermis_embryo_SelectivelyEnriched
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00038289:oocyte_protein
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00042561:smg-2(RNAi)_downregulated
      WBPaper00042561:smgl-1(RNAi)_downregulated
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044316:CH3HgCl_2.0uM_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044426:rotenone_5day_downregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00045017:blmp-1(tm548)_downregulated
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00046887:WNT-target
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:skn-1(RNAi)_downregulated_glp-1(ts)-dependent
      WBPaper00048923:Aging_regulated
      WBPaper00049377:MWCNT_upregulated
      WBPaper00049498:npr-1(ur89)_regulated_4
      WBPaper00050121:mir-60(n4947)_upregulated
      WBPaper00050163:chd-3(eh4)_upregulated_100-cell-embryo
      WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050636:aging_regulated_insoluble_protein
      WBPaper00050717:let-7(n2853)_lin-41(xe11)_upregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050843:sesamin_downregulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050903:mir-35-41(nDf50)_25C_downregulated
      WBPaper00051265:F4_hrde-1(tm1200)_downregulated
      WBPaper00051352:Long-Term-Association-Memory_upregulated
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00051558:aging_regulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053615:SMO-1_target
      WBPaper00053664:ins-11(tm1053)_upregulated
      WBPaper00053771:up_at_24h-NaCl
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Metformin_upregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056165:MINA-1_interacting_mRNA
      WBPaper00056167:Cry5B_upregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056169:rrf-3(pk1426)_upregulated_L2
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058711:skn-1(lax188)_upregulated
      WBPaper00059224:serotonin_downregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059735:glucose_upregulated_lpin-1(RNAi)
      WBPaper00059735:glucose_upregulated_N2
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060445:nfki-1(cer1)_downregulated_L4
      WBPaper00060526:plp-1(ok2155)_downregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061340:G2_and_W_blasts
      WBPaper00061340:hyp4_hyp5_hyp6
      WBPaper00061340:hyp7_AB_lineage
      WBPaper00061340:hyp7_C_lineage
      WBPaper00061340:P_cell
      WBPaper00061340:Tail_hypodermis
      WBPaper00061377:PAN-1_interacting
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061527:F58E6.13_17427-ifa-3
      WBPaper00062002:L3_secretome
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062347:blmp-1(tm548)_downregulated
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064163:ZNFX-1_interacting_embryo
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064532:pals-25(icb98)_downregulated
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064661:lpd-3(ok2138)_upregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00064992:heat-shock_upregulated
      WBPaper00065029:cadmium_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065560:E.coli-HB101_downregulated_F3
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065746:eat-2(ad1113)_downregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065877:rege-1(imm070)_upregulated_OP50
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066093:E.coli-purE_downregulated
      WBPaper00066204:CdCl2_downregulated_mRNA
      WBPaper00066232:ash-2(RNAi)_upregulated_WT
      WBPaper00066232:hsf-1(RNAi)_downregulated_WT
      cgc4386_cluster_5_1
      WBPaper00026952:class_B
      WBPaper00027111:rrf-2(ok210)_upregulated
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00032062:age_regulated_genes
      WBPaper00032165:differentially_expressed_with_age_medoid_3
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_old
      WBPaper00045673:colistin_upregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
      [cgc6390]:male_sex-enriched
    Interaction (71)
  Map_info: Map: X Position: 23.7263 Error: 0.00238
    Positive: Positive_clone: F52E10 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (15)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene