Predicted to be involved in protein glycosylation. Human ortholog(s) of this gene implicated in Fukuyama congenital muscular dystrophy; Walker-Warburg syndrome; autosomal recessive limb-girdle muscular dystrophy type 2L; autosomal recessive limb-girdle muscular dystrophy type 2M; dilated cardiomyopathy (multiple); and muscular dystrophy-dystroglycanopathy type B4. Is an ortholog of human FKTN (fukutin).
The human ortholog of elegans TO7D3.4, Fukutin, is required for normal glycosylation of the cell surface laminin receptor, alpha-dystroglycan; mutations in Fukutin cause cardiomyopathy and Fukuyama-type congenital muscular dystrophy (FCMD), an inherited condition that predominantly affects the muscles, brain, and eyes, due to weakness and wasting of skeletal muscles.