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WormBase Tree Display for Gene: WBGene00002981

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Name Class

WBGene00002981EvidenceCGC_data_submission
SMapS_parentSequenceZK593
IdentityVersion2
NameCGC_namelgg-2Person_evidenceWBPerson321
Sequence_nameZK593.6
Molecular_nameZK593.6a
ZK593.6a.1
CE50405
ZK593.6b
CE45416
ZK593.6b.1
Other_nameatg-8.2Person_evidenceWBPerson649
CELE_ZK593.6Accession_evidenceNDBBX284604
Public_namelgg-2
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:30WBPerson1971EventImportedInitial conversion from geneace
229 Feb 2008 11:29:00WBPerson2970Name_changeOther_nameatg-8.2
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlgg
AlleleWBVar02145373
WBVar01499336
WBVar01500079
WBVar01795403
WBVar01498996
WBVar01499372
WBVar01499925
WBVar00191911
WBVar00434978
WBVar00434979
WBVar00434980
WBVar01499596
WBVar00604024
WBVar02058848
WBVar01857589
WBVar01857590
WBVar01857591
WBVar02124206
WBVar02125195
WBVar01731029
WBVar01731030
WBVar01731031
WBVar01731032
WBVar02145372
WBVar00940507
WBVar00940508
WBVar00940509
WBVar00940510
WBVar00940511
WBVar00940512
WBVar01474464
WBVar00940513
WBVar00940514
WBVar00940515
WBVar00940516
WBVar00940517
WBVar01500245
RNASeq_FPKM (74)
GO_annotation (27)
Ortholog (40)
ParalogWBGene00002980Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionlgg-2 encodes an ortholog of the autophagic budding yeast protein Atg8p;LGG-2 is also homologous the light chain 3 (LC3) subunit of themicrotubule-associated proteins 1A and 1B (MAP1A and MAP1B); LGG-2 is predicted to associate with MAP1A and MAP1B and with microtubules and toperhaps play a role in regulating the microtubule-binding activity ofMAP1A and MAP1B; LGG-2 has no obvious function in RNAi assays, and isnot required for either dauer formation or extended lifespan.Paper_evidenceWBPaper00005654
WBPaper00006070
WBPaper00031504
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated16 Mar 2008 00:00:00
Automated_descriptionPredicted to enable microtubule binding activity and ubiquitin protein ligase binding activity. Involved in cellular response to toxic substance; defense response to other organism; and positive regulation of autophagosome maturation. Acts upstream of or within with a positive effect on plasma membrane repair. Located in autophagosome membrane. Expressed in hypodermis; muscle cell; pharynx; spermatheca; and vulva. Human ortholog(s) of this gene implicated in glioblastoma; hypertrophic cardiomyopathy; and liver cirrhosis. Is an ortholog of human MAP1LC3A (microtubule associated protein 1 light chain 3 alpha); MAP1LC3B (microtubule associated protein 1 light chain 3 beta); and MAP1LC3B2 (microtubule associated protein 1 light chain 3 beta 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:3068Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6838)
DOID:11984Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6838)
DOID:5082Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6838)
Molecular_infoCorresponding_CDSZK593.6a
ZK593.6b
Corresponding_CDS_historyZK593.6a:wp246
Corresponding_transcriptZK593.6a.1
ZK593.6b.1
Other_sequence (78)
Associated_featureWBsf652170
WBsf652171
WBsf652172
WBsf655526
WBsf655527
WBsf668280
WBsf668281
WBsf981818
WBsf997731
WBsf997732
WBsf1018155
WBsf1018156
WBsf230799
WBsf230800
WBsf230801
Experimental_infoRNAi_result (21)
Expr_patternExpr9088
Expr11489
Expr12743
Expr1019064
Expr1031381
Expr1162945
Expr2013143
Expr2031375
Drives_constructWBCnstr00009398
WBCnstr00013713
WBCnstr00019050
WBCnstr00022725
WBCnstr00036308
Construct_productWBCnstr00009398
WBCnstr00013713
WBCnstr00019050
WBCnstr00022269
WBCnstr00036308
AntibodyWBAntibody00002496
WBAntibody00002979
Microarray_results (29)
Expression_clusterWBPaper00032031:DConiospora_downregulated_cDNA_12h
WBPaper00032425:down_in_rde-4
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00033070:Elbe_upregulated
WBPaper00034761:hlh-30_downregulated
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00038061:aldicarb_downregulated
WBPaper00038118:aak-2(gt33)_upregulated
WBPaper00040221:DAF-12_target_ALF4
WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
WBPaper00043951:insoluble_protein_day16_N2
WBPaper00044736:flat_dev_expression
WBPaper00044857:BAR-1_downregulated
WBPaper00045257:bar-1(ga80)_upregulated
WBPaper00045314:S.aureus-induced_N2
WBPaper00045521:Gender_Neutral
WBPaper00045774:clk-1_upregulated
WBPaper00046509:htz-1(ok3099)_upregulated
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049495:starvation-refeeding_regulated
WBPaper00049545:cco-1(RNAi)_upregulated
WBPaper00049732:blmp-1(tm548)_vs_N2_upregulated
WBPaper00049942:HeatShock_downregulated_hsf-1(+)
WBPaper00050199:hsf-1(ok600)_upregulated
WBPaper00050344:AFD-neuron_enriched
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050412:cco-1(RNAi)_upregulated_N2
WBPaper00050468:hlh-30-dependent_Cry5B_regulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051257:Levamisole_upregulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053295:lin-22(ot267)_downregulated
WBPaper00053295:lin-22(ot269)_downregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053388:dauer_regulated_Cluster2
WBPaper00053599:oocyte_vs_mitosis_downregulated
WBPaper00053810:daf-2(e1370)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00055013:hmg-3(bar24)_upregulated
WBPaper00055049:S.gordonii_upregulated
WBPaper00055648:germline_expressed
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00055897:heat-shock_downregulated
WBPaper00056139:soil-microbiota_upregulated
WBPaper00056165:MINA-1_interacting_mRNA
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00056868:P.aeruginosa_upregulated_smallRNA
WBPaper00057041:unc-70(cas983)_downregulated
WBPaper00057068:Cadmium_upregulated
WBPaper00057154:HeatShock_downregulated_mRNA
WBPaper00057154:HeatShock_upregulated_miRNA-target
WBPaper00058948:PA14_downregulated
WBPaper00059174:MEG-3_interacting
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059471:EGL-43_interacting
WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated
WBPaper00059754:C.neoformans_H99_upregulated
WBPaper00059754:P.aeruginosa_PA14_upregulated
WBPaper00059763:neuron_expressed
WBPaper00059895:wounding_upregulated
WBPaper00059987:Wounding_upregulated
WBPaper00060084:cco-1(RNAi)_upregulated_N2
WBPaper00060634:fhod-1(tm2363)_upregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00060871:M.humicola-infection_48h_regulated
WBPaper00060909:atfs-1(cmh15)_upregulated
WBPaper00061409:neuronal-fzo-1(RNAi)_upregulated
WBPaper00061527:cdc-42_17192-rab-5_18073
WBPaper00061527:cids-2_2203-attf-2_2451
WBPaper00061651:AIZ_enriched
WBPaper00061753:csr-1(tor159)_downregulated_20C
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062520:qui-1(db104)_upregulated
WBPaper00062590:Aging_upregulated_coelomocyte
WBPaper00062590:Aging_upregulated_neuron
WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
WBPaper00064005:starvation_upregulated_N2_mRNA
WBPaper00064055:trl-1(cas1077)_downregulated_starved
WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064532:pals-25(icb98)_upregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064871:hypoxia_downregulated_F1
WBPaper00065096:25C_vs_20C_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065746:tmc-1(rg1003)_downregulated
WBPaper00065975:P-body_vs_oocyte_enriched
WBPaper00065975:P-body_vs_WholeAnimal_enriched
WBPaper00065995:M.humicola-extract_downregulated_N2
WBPaper00066062:xrep-4(lax137)_upregulated
cgc4386_cluster_6_2
cgc4489_group_17
WBPaper00025032:cluster_7
WBPaper00025032:cluster_95
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00027722:Microbacterium_nematophilum_upregulated
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00031252:AIN-2_IP_enriched
WBPaper00031532:Larva_Pan_Neuronal_Enriched
WBPaper00032948:StarveUp2
WBPaper00034739:N2moreDR1350
WBPaper00034757:up_by_oxidative_stress
WBPaper00035084:L2_enriched_AIN-2_IP
WBPaper00035227:heat_shock_regulated
WBPaper00035588:alg-1(-)_upregulated
WBPaper00035905:FBF-1_Associated
WBPaper00036286:Pattern_F
WBPaper00037695:CC_3-day
WBPaper00037901:GLD-1_mRNA_targets
WBPaper00038172:tax-6null_up_regulated
WBPaper00038231:Cry5B_1.5-fold_upregulated
WBPaper00038231:Cry5B_2-fold_upregulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040963:TA100_down
WBPaper00040963:TA300_down
WBPaper00040985:AIN-2_asynchronous_muscle
WBPaper00041207:CE_dauer_up
WBPaper00041370:spg-7(RNAi)_upregulated
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00042548:miRISC_enriched
WBPaper00047070:N2_starvation_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00048989:N2_allantoin_downregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
WBPaper00057098:SiO2-nanoparticles_upregulated
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(53_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
Interaction (120)
Map_infoMapIVPosition4.75551Error0.001217
PositivePositive_cloneZK593Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (48)
RemarkSequence connection from [Kimura Y]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene