WormBase Tree Display for Gene: WBGene00020347

WBGene00020347 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 2
    Name: CGC_name: ech-1.2 Person_evidence: WBPerson2819
      Sequence_name: T08B2.7
      Molecular_name: T08B2.7a
        T08B2.7a.1
        CE13431
        T08B2.7b
        CE26950
        T08B2.7b.1
        T08B2.7b.2
        T08B2.7b.3
      Other_name: CELE_T08B2.7 Accession_evidence: NDB BX284601
      Public_name: ech-1.2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:03 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 25 Sep 2014 10:29:23 WBPerson2970 Name_change: CGC_name: ech-1.2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ech
    Allele (44)
    Strain: WBStrain00003519
    RNASeq_FPKM (74)
    GO_annotation (20)
    Contained_in_operon: CEOP1312
    Ortholog (43)
    Paralog: WBGene00001150 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00001157 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00001158 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00007129 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00010035 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00019978 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00022130 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: ech-1.2 encodes one of two C. elegans enoyl-CoA hydratases/long-chain 3-hydroxyacyl-CoA dehydrogenases [EC:4.2.1.17 1.1.1.211] orthologous to human HADHA (hydroxyacyl-coenzyme A dehydrogenase/3-ketoacyl-coenzyme A thiolase/enoyl-coenzyme a hydratase (trifunctional protein), alpha subunit OMIM:600890), which when mutated leads to disease. Curator_confirmed: WBPerson1843
            WBPerson1823
            WBPerson567
          Date_last_updated: 12 Nov 2014 00:00:00
      Automated_description: Predicted to enable enoyl-CoA hydratase activity and long-chain-3-hydroxyacyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial fatty acid beta-oxidation multienzyme complex. Expressed in tail. Human ortholog(s) of this gene implicated in Alzheimer's disease; fatty liver disease; and mitochondrial trifunctional protein deficiency. Is an ortholog of human HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4801)
      DOID:9452 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4801)
      DOID:0111277 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4801)
  Molecular_info: Corresponding_CDS: T08B2.7a
      T08B2.7b
    Corresponding_CDS_history: T08B2.7c:wp274
    Corresponding_transcript: T08B2.7a.1
      T08B2.7b.1
      T08B2.7b.2
      T08B2.7b.3
    Other_sequence (113)
    Associated_feature: WBsf655275
      WBsf664328
      WBsf983864
      WBsf219554
      WBsf219555
      WBsf219556
      WBsf219557
      WBsf219558
  Experimental_info: RNAi_result (17)
    Expr_pattern: Expr6639
      Expr1023592
      Expr1038864
      Expr1156447
      Expr2011165
      Expr2029401
    Drives_construct: WBCnstr00003977
      WBCnstr00025203
    Construct_product: WBCnstr00025203
    Microarray_results (36)
    Expression_cluster: WBPaper00027057:DCR-1_interacting_embryo
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00035073:mitochondria_protein
      WBPaper00035269:cde-1_regulated
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037682:sma-2_upregulated
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_embryo_SelectivelyEnriched
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00038118:stress_upregulated_N2
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038289:oocyte_protein
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040446:insoluble_protein
      WBPaper00040965:lipid-droplet_associated_protein
      WBPaper00040965:top50_lipid-droplet_associated_protein
      WBPaper00044034:LEC-1_associated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00045729:gld-2(RNAi)_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049159:Microwave_upregulated_adult
      WBPaper00049217:TCER-1_upregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050636:aging_regulated_insoluble_protein
      WBPaper00050698:DEP-1_interacting
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051555:atm-1(gk186)_regulated_protein
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055648:sperm_expressed
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:SGP_biased
      WBPaper00056900:PID-3_interacting
      WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated
      WBPaper00057288:Cold_upregulated_transcript
      WBPaper00058691:CFP-1_interacting_protein
      WBPaper00058691:sin-3(tm1276)_upregulated
      WBPaper00059174:MEG-3_interacting
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059605:MUT-16_interacting
      WBPaper00060084:DVE-1_interacting_protein_cco-1(RNAi)
      WBPaper00060084:DVE-1_interacting_protein_control
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061340:Intestine
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:K10C9.3_8160-Y39G8B.1_58
      WBPaper00061818:ELKS-1_interacting
      WBPaper00062143:PQN-59_interacting
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064122:vulva_transcriptome
      WBPaper00064201:SNA-3_interacting
      WBPaper00064257:UNG-1_interacting
      WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
      WBPaper00064716:paraquat_downregulated
      WBPaper00064750:1mg-nanoplastics_upregulated_protein
      WBPaper00064750:10mg-nanoplastics_upregulated_protein
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065746:eat-2(ad1113)_downregulated
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      cgc4489_group_7
      cgc4489_group_8
      WBPaper00025032:cluster_53
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00032948:FedUp
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036375:depleted_in_PVD_OLL
      WBPaper00037113:CPF_16C_down-regulated
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_rapamycin_downregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:intrinsic
    Interaction (147)
  Map_info: Map: I Position: 0.878928
    Positive: Positive_clone: T08B2 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00026800
    WBPaper00031865
    WBPaper00033136
    WBPaper00038491
    WBPaper00041771
    WBPaper00042257
    WBPaper00055090
    WBPaper00065140
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene