WormBase Tree Display for Gene: WBGene00001150
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| WBGene00001150 | Evidence | Person_evidence | WBPerson3205 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Author_evidence | Van Gilst M | ||||||||
| SMap | S_parent | Sequence | CHROMOSOME_V | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | ech-1.1 | Person_evidence | WBPerson2819 | |||||
| Sequence_name | C29F3.1 | ||||||||
| Molecular_name | C29F3.1 | ||||||||
| C29F3.1.1 | |||||||||
| CE08435 | |||||||||
| C29F3.1.2 | |||||||||
| Other_name | ech-1 | ||||||||
| CELE_C29F3.1 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | ech-1.1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 24 Sep 2014 15:46:18 | WBPerson2970 | Name_change | CGC_name | ech-1.1 | ||||
| Other_name | ech-1 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ech | ||||||||
| Allele (108) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00020347 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001157 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001158 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00007129 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00010035 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019978 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00022130 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | ech-1.1 encodes one of two C. elegans enoyl-CoA hydratases/long-chain 3-hydroxyacyl-CoA dehydrogenases [EC:4.2.1.17 1.1.1.211] orthologous to human HADHA (hydroxyacyl-coenzyme A dehydrogenase/3-ketoacyl-coenzyme A thiolase/enoyl-coenzyme a hydratase (trifunctional protein), alpha subunit OMIM:600890), which when mutated leads to disease; loss of ech-1.1 activity via RNAi results in an increase in overall body fat, consistent with ECH-1.1's predicted role in fatty acid metabolism; expression of ech-1.1 mRNA is positively regulated by the NHR-49 nuclear receptor. | Paper_evidence | WBPaper00025114 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 12 Nov 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable enoyl-CoA hydratase activity and long-chain-3-hydroxyacyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial fatty acid beta-oxidation multienzyme complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; fatty liver disease; and mitochondrial trifunctional protein deficiency. Is an ortholog of human HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4801) | ||||
| DOID:9452 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4801) | ||||||
| DOID:0111277 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4801) | ||||||
| Molecular_info | Corresponding_CDS | C29F3.1 | |||||||
| Corresponding_transcript | C29F3.1.1 | ||||||||
| C29F3.1.2 | |||||||||
| Other_sequence (22) | |||||||||
| Associated_feature | WBsf1020998 | ||||||||
| WBsf1020999 | |||||||||
| WBsf235055 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00011330 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00092839 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092838 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00029316 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00114314 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00102614 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00041460 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1025014 | ||||||||
| Expr1030731 | |||||||||
| Expr1145489 | |||||||||
| Expr2011164 | |||||||||
| Expr2029400 | |||||||||
| Drives_construct | WBCnstr00037984 | ||||||||
| Construct_product | WBCnstr00037984 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (192) | |||||||||
| Interaction (52) | |||||||||
| WBProcess | WBbiopr:00000121 | ||||||||
| Map_info | Map | V | Position | 7.90196 | Error | 0.00321 | |||
| Positive | Positive_clone | C29F3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (19) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
