WormBase Tree Display for Gene: WBGene00019327

WBGene00019327 SMap: S_parent: Sequence: K02F3
  Identity: Version: 2
    Name: CGC_name: zip-2 Person_evidence: WBPerson1997
            WBPerson460
      Sequence_name: K02F3.4
      Molecular_name: K02F3.4
        K02F3.4.1
        CE23848
        K02F3.4.2
        K02F3.4.3
      Other_name: CELE_K02F3.4 Accession_evidence: NDB BX284603
      Public_name: zip-2
    DB_info: Database: AceView gene 3B453
        WormQTL gene WBGene00019327
        WormFlux gene WBGene00019327
        NDB locus_tag CELE_K02F3.4
        Panther gene CAEEL|WormBase=WBGene00019327|UniProtKB=Q21148
          family PTHR23334
        NCBI gene 175240
        RefSeq protein NM_001384015.2
        SwissProt UniProtAcc Q21148
        TREEFAM TREEFAM_ID TF317134
        UniProt_GCRP UniProtAcc Q21148
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:01 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 18 Jul 2005 13:34:00 WBPerson2970 Name_change: CGC_name: zip-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: zip
    Allele (51)
    Strain: WBStrain00037649
    RNASeq_FPKM (74)
    GO_annotation (25)
    Ortholog (23)
    Paralog: WBGene00016754 Caenorhabditis elegans From_analysis: Panther
      WBGene00016997 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017755 Caenorhabditis elegans From_analysis: Panther
      WBGene00021552 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: zip-2 encodes a bZIP transcription factor; ZIP-2 activity is required for regulating one branch of the immune response pathway that responds to infection by virulent strains of the bacterial pathogen Pseudomonas aeruginosa; specifically, ZIP-2 is required for inducing expression of a subset of infection response genes, including irg-1 and irg-2, and for full resistance to P. aeruginosa infection. Paper_evidence: WBPaper00027309
            WBPaper00035891
          Curator_confirmed: WBPerson1843
          Date_last_updated: 08 Feb 2010 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in defense response to bacterium and positive regulation of macromolecule biosynthetic process. Predicted to be located in nucleus. Expressed in pharynx. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Modifies_disease: DOID:14330
  Modifies_disease_in_annotation: WBDOannot00000499
  Molecular_info: Corresponding_CDS: K02F3.4
    Corresponding_transcript: K02F3.4.1
      K02F3.4.2
      K02F3.4.3
    Other_sequence (25)
    Associated_feature (16)
    Gene_product_binds: WBsf977574
      WBsf977575
      WBsf977578
      WBsf977579
      WBsf977583
      WBsf977586
      WBsf977588
      WBsf977590
      WBsf977592
      WBsf977593
      WBsf977595
      WBsf977596
      WBsf977597
      WBsf977599
      WBsf977602
      WBsf977603
      WBsf977605
      WBsf977607
      WBsf977608
      WBsf977609
      WBsf977610
      WBsf977612
      WBsf977614
      WBsf977617
      WBsf977618
      WBsf977619
      WBsf977623
      WBsf977624
      WBsf977625
      WBsf977626
      WBsf977628
      WBsf977631
      WBsf977632
      WBsf977635
      WBsf977639
      WBsf977640
      WBsf977641
      WBsf977643
      WBsf977645
      WBsf977646
      WBsf977647
      WBsf977648
      WBsf977649
      WBsf977651
      WBsf977652
      WBsf977653
      WBsf977654
      WBsf977655
      WBsf977657
      WBsf977658
      WBsf977660
      WBsf977661
      WBsf977662
      WBsf977663
      WBsf977665
      WBsf977666
      WBsf977667
      WBsf977668
      WBsf977669
      WBsf977670
      WBsf977671
      WBsf977672
      WBsf977674
      WBsf977677
      WBsf977679
      WBsf977681
      WBsf977682
      WBsf977683
      WBsf977686
      WBsf977687
      WBsf977688
      WBsf977691
      WBsf977692
      WBsf977694
      WBsf977697
      WBsf977698
      WBsf977699
      WBsf977700
      WBsf977701
      WBsf977702
      WBsf977703
      WBsf977704
      WBsf977705
      WBsf977706
      WBsf977709
      WBsf977711
      WBsf977712
      WBsf977713
      WBsf977714
      WBsf977718
      WBsf977719
      WBsf977721
      WBsf977722
      WBsf977723
      WBsf977725
      WBsf977726
      WBsf977728
      WBsf977729
      WBsf977730
      WBsf977732
      WBsf977733
      WBsf977734
      WBsf977735
      WBsf977736
      WBsf977738
      WBsf977740
      WBsf977743
      WBsf977744
      WBsf977746
      WBsf977747
      WBsf977748
      WBsf977749
      WBsf977750
      WBsf977751
      WBsf977752
      WBsf977754
      WBsf977757
      WBsf977759
      WBsf977762
      WBsf977763
      WBsf977764
      WBsf977765
      WBsf977768
      WBsf977769
      WBsf977770
      WBsf977771
      WBsf977774
      WBsf977775
      WBsf977776
      WBsf977777
      WBsf977783
      WBsf977784
      WBsf977786
      WBsf977787
      WBsf977789
      WBsf977790
      WBsf977791
      WBsf977792
      WBsf977793
      WBsf977794
      WBsf977796
      WBsf977800
      WBsf977801
      WBsf977802
      WBsf977803
      WBsf977806
      WBsf977807
      WBsf977808
      WBsf977809
      WBsf977812
      WBsf977813
      WBsf977814
      WBsf977816
      WBsf977818
      WBsf977819
      WBsf977820
      WBsf977821
      WBsf977822
      WBsf977823
      WBsf977825
      WBsf977826
      WBsf977828
      WBsf977830
      WBsf977831
      WBsf977833
      WBsf977836
      WBsf977838
      WBsf977840
      WBsf977841
      WBsf977842
      WBsf977843
      WBsf977844
      WBsf977845
      WBsf977846
      WBsf977848
      WBsf977849
      WBsf977851
      WBsf977853
      WBsf977854
      WBsf977856
      WBsf977857
      WBsf977858
      WBsf977859
      WBsf977860
      WBsf977861
      WBsf977862
      WBsf977863
      WBsf977864
      WBsf977865
      WBsf977870
      WBsf977873
      WBsf977874
      WBsf977875
      WBsf977876
      WBsf977877
      WBsf977878
      WBsf977880
      WBsf977881
      WBsf977883
      WBsf977884
      WBsf977885
      WBsf977888
      WBsf977889
      WBsf977890
      WBsf977891
      WBsf977893
      WBsf977894
      WBsf977896
      WBsf977897
      WBsf977898
      WBsf977899
      WBsf977900
      WBsf977903
      WBsf977904
      WBsf977905
      WBsf977906
      WBsf977907
      WBsf977908
      WBsf977910
      WBsf977911
      WBsf977912
      WBsf977913
      WBsf977914
      WBsf977915
      WBsf977917
      WBsf977918
      WBsf977919
      WBsf977920
      WBsf977921
      WBsf977922
      WBsf977923
      WBsf977924
      WBsf977925
      WBsf977926
      WBsf977927
      WBsf977928
      WBsf977929
      WBsf977931
      WBsf977932
      WBsf977933
      WBsf977934
      WBsf977936
      WBsf977937
      WBsf977939
      WBsf977940
      WBsf977941
      WBsf977943
      WBsf977946
      WBsf977948
    Transcription_factor: WBTranscriptionFactor000223
  Experimental_info: RNAi_result (25)
    Expr_pattern: Expr7776
      Expr10045
      Expr1020648
      Expr1038353
      Expr1153467
      Expr2018156
      Expr2036293
    Drives_construct: WBCnstr00012921
      WBCnstr00015019
      WBCnstr00015163
      WBCnstr00019915
      WBCnstr00022575
      WBCnstr00025914
    Construct_product: WBCnstr00016820
      WBCnstr00018893
      WBCnstr00018894
      WBCnstr00019915
      WBCnstr00022575
      WBCnstr00025914
    Regulate_expr_cluster: WBPaper00035891:PA_induced_zip-2_dependent
      WBPaper00035891:zip-2(RNAi)_downregulated
      WBPaper00035891:zip-2(RNAi)_upregulated
      WBPaper00053605:zip-2(RNAi)_downregulated
      WBPaper00053605:zip-2(RNAi)_upregulated
    Microarray_results (21)
    Expression_cluster: WBPaper00028867:HLH-1_induced_TF
      WBPaper00028867:PAL-1_induced_TF
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00033444:BacteriaDiet_regulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037682:sma-2_upregulated
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00038118:stress_upregulated_N2
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040990:PA14_upregulated
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00048988:neuron_expressed
      WBPaper00049001:EVN_enriched
      WBPaper00049498:npr-1(ur89)_regulated_1
      WBPaper00049626:UNC-75_target
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00050053:muscle_enriched_Day4
      WBPaper00050053:muscle_enriched_Day12
      WBPaper00050182:lmn-1(L535P)_downregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051558:fog-2(q71)_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster6
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056034:pals-25(jy9)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056826:SGP_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057162:meg-3_meg-4_upregulated_sRNA
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059191:hsp-16.2p-LIN-29_downregulated
      WBPaper00059194:KLF-1_interacting
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_N2
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061040:FW1256_downregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061274:microgravity_downregulated
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061527:kin-29_2839-unc-9_3883
      WBPaper00061651:ASG_enriched
      WBPaper00061651:DB_enriched
      WBPaper00061651:DVB_enriched
      WBPaper00061651:IL2_DV_enriched
      WBPaper00061651:IL2_LR_enriched
      WBPaper00061651:MI_enriched
      WBPaper00061651:PDE_enriched
      WBPaper00061651:RIB_enriched
      WBPaper00061651:SIA_enriched
      WBPaper00061651:SIB_enriched
      WBPaper00061651:VB01_enriched
      WBPaper00061651:VB02_enriched
      WBPaper00061651:VB_enriched
      WBPaper00061651:VD_DD_enriched
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062056:lin-35(n745)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_upregulated
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062456:doxycycline_upregulated_CB4856_transcript
      WBPaper00062456:doxycycline_upregulated_N2_transcript
      WBPaper00064055:trl-1(cas1077)_downregulated_non-starved
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064315:mes-3(bn199)_upregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064716:paraquat_downregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066085:hda-3(ok1991)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      cgc4386_cluster_6_2
      WBPaper00006465:II_ethanol_late_induction
      WBPaper00025032:cluster_2
      WBPaper00025099:MA_specific
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00028789:pmk-1_upregulated
      WBPaper00029437:dcr-1_upregulated
      WBPaper00031060:2-deoxy-D-glucose_upregulated
      WBPaper00031832:slr-2_regulated
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00035227:heat_shock_regulated
      WBPaper00035429:UVC_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035891:PA_induced_zip-2_dependent
      WBPaper00035891:zip-2(RNAi)_downregulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_D
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00038427:lin-54_embryo_changed
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041174:environmental
      WBPaper00041174:genotype_environment_interaction
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00044091:Bpseudomallei_induced_2h
      WBPaper00044091:Bpseudomallei_induced_4h
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00044091:Bpseudomallei_induced_12h
      WBPaper00045015:acs-3(ft5)_upregulated
      WBPaper00045015:nhr-25(RNAi)_upregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00045865:biofilm_upregulated_A
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00050515:pmk-1(km25)_downregulated
      WBPaper00050520:lagr-1(gk327);hyl-1(ok976)_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:cluster_2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(66_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SE_pi(66_min)
      [cgc6390]:Cluster_A
    Interaction (49)
    WBProcess: WBbiopr:00000008
      WBbiopr:00000039
  Map_info: Map: III Position: -25.7689
    Positive: Positive_clone: K02F3 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (32)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
    [200811 gw3] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (-25.7711)
  Method: Gene