WormBase Tree Display for Gene: WBGene00013878

WBGene00013878 SMap: S_parent: Sequence: CHROMOSOME_V
  Identity: Version: 2
    Name: CGC_name: atfs-1 Person_evidence: WBPerson9073
      Sequence_name: ZC376.7
      Molecular_name (15)
      Other_name: CELE_ZC376.7 Accession_evidence: NDB BX284605
      Public_name: atfs-1
    DB_info: Database: AceView gene 5O677
        WormQTL gene WBGene00013878
        WormFlux gene WBGene00013878
        NDB locus_tag CELE_ZC376.7
        Panther gene CAEEL|WormBase=WBGene00013878|UniProtKB=Q23272
          family PTHR13044
        NCBI gene 179922
        RefSeq protein NM_001269642.3
            NM_182360.9
            NM_074114.7
            NM_001029131.6
        SwissProt UniProtAcc Q23272
        TREEFAM TREEFAM_ID TF315772
        UniProt_GCRP UniProtAcc Q23272
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:55 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 24 May 2011 10:23:31 WBPerson2970 Name_change: CGC_name: atfs-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: atfs
    Allele (102)
    Strain: WBStrain00031161
      WBStrain00031162
      WBStrain00031163
      WBStrain00031164
      WBStrain00037720
      WBStrain00052571
      WBStrain00052572
      WBStrain00052468
    RNASeq_FPKM (74)
    GO_annotation (68)
    Ortholog (23)
    Paralog: WBGene00000221 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007932 Caenorhabditis elegans From_analysis: Panther
      WBGene00012330 Caenorhabditis elegans From_analysis: Panther
      WBGene00077761 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: atfs-1 encodes a bZip transcription factor; ATFS-1 is required for the mitochondrial unfolded protein response (UPRmt); in wild-type animals, ATFS-1 is imported into the mitochondria and degraded, but in response to perturbed mitchondrial protein folding and decreased mitochondrial import efficiency, some ATFS-1 accumulates in the cytosol and then, traffics to the nucleus. Paper_evidence: WBPaper00035985
            WBPaper00041370
          Curator_confirmed: WBPerson1843
          Date_last_updated: 23 Oct 2012 00:00:00
      Automated_description: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding activity; and mitochondrial transcription factor activity. Involved in several processes, including mitochondrial unfolded protein response; positive regulation of nematode larval development; and regulation of gene expression. Located in mitochondrial matrix and nucleus. Human ortholog(s) of this gene implicated in prostate carcinoma. Is an ortholog of human ATF4 (activating transcription factor 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10286 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:786)
  Molecular_info: Corresponding_CDS: ZC376.7a
      ZC376.7b
      ZC376.7c
      ZC376.7d
    Corresponding_CDS_history: ZC376.7:wp87
    Corresponding_transcript: ZC376.7a.1
      ZC376.7a.2
      ZC376.7b.1
      ZC376.7b.2
      ZC376.7c.1
      ZC376.7c.2
      ZC376.7d.1
    Other_sequence: CJC10202_1
      CR05510
      CJC00946_1
      CR05812
      MH00118
      Hbac_isotig01486
      CRC00297_1
      CBC02450_1
    Associated_feature (16)
    Gene_product_binds: WBsf980914
    Transcription_factor: WBTranscriptionFactor000444
  Experimental_info: RNAi_result (55)
    Expr_pattern: Expr8935
      Expr9728
      Expr9743
      Expr1015095
      Expr1036209
      Expr1162304
      Expr2009484
      Expr2027721
    Drives_construct: WBCnstr00013629
      WBCnstr00014248
      WBCnstr00014263
      WBCnstr00029481
    Construct_product: WBCnstr00013629
      WBCnstr00021929
      WBCnstr00029481
      WBCnstr00038813
    Regulate_expr_cluster (12)
    Antibody: WBAntibody00002652
    Microarray_results (32)
    Expression_cluster: WBPaper00032031:DConiospora_upregulated_cDNA_12h
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
      WBPaper00044736:flat_dev_expression
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Oogenic
      WBPaper00048988:neuron_expressed
      WBPaper00049217:TCER-1_upregulated
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051558:fog-2(q71)_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:Rapamycin_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055648:germline_expressed
      WBPaper00055941:atfs-1(gk3094)_downregulated
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_downregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058691:cfp-1(tm6369)_upregulated
      WBPaper00058691:sin-3(tm1276)_upregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061527:tars-1-AFFX-r2-3026-5_at
      WBPaper00064716:paraquat_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00066062:xrep-4(lax137)_upregulated
      cgc4386_cluster_3_4
      cgc4489_group_24
      WBPaper00025032:cluster_4
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00029437:rde-4_upregulated
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00030985:Erwinia_carotovora_upregulated
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00033101:spr-5_regulated
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00040985:AIN-2_L4_intestine
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045263:ProLongevity-mtROS_upregulated
      WBPaper00055899:nitroguanidine_regulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(41_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
    Interaction (975)
    WBProcess: WBbiopr:00000077
      WBbiopr:00000079
  Map_info (3)
  Reference (127)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene