WormBase Tree Display for Gene: WBGene00009628

WBGene00009628 SMap: S_parent: Sequence: F42D1
  Identity: Version: 2
    Name: CGC_name: tatn-1 Person_evidence: WBPerson2977
      Sequence_name: F42D1.2
      Molecular_name: F42D1.2
        F42D1.2.1
        CE10298
      Other_name: CELE_F42D1.2 Accession_evidence: NDB BX284606
      Public_name: tatn-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:50 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 26 Nov 2009 11:16:28 WBPerson9133 Name_change: CGC_name: tatn-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: tatn
    Allele (54)
    Strain: WBStrain00000172
      WBStrain00037460
    Component_of_genotype: WBGenotype00000122
      WBGenotype00000127
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (40)
    Paralog (4)
    Structured_description: Concise_description: tatn-1 encodes a putative tyrosine aminotransferase, orthologous to human TAT (OMIM:276600, mutated in type II tyrosinemia); tatn-1 is expressed in larval and adult pharynx, hypodermis, body wall muscle, and intestine, and in adult vulval muscle and reproductive system; tatn-1 is required for the tyrosinemic phenotype of fah-1(RNAi) animals. Paper_evidence: WBPaper00006525
            WBPaper00031006
            WBPaper00031468
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 14 Dec 2009 00:00:00
      Automated_description: Predicted to enable L-tyrosine:2-oxoglutarate aminotransferase activity. Involved in dauer entry. Human ortholog(s) of this gene implicated in tyrosinemia type II. Is an ortholog of human TAT (tyrosine aminotransferase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050725 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11573)
      DOID:9275 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11573)
  Molecular_info: Corresponding_CDS: F42D1.2
    Corresponding_transcript: F42D1.2.1
    Other_sequence (141)
    Associated_feature (11)
  Experimental_info: RNAi_result: WBRNAi00113315 Inferred_automatically: RNAi_primary
      WBRNAi00113142 Inferred_automatically: RNAi_primary
      WBRNAi00117421 Inferred_automatically: RNAi_primary
      WBRNAi00117425 Inferred_automatically: RNAi_primary
      WBRNAi00032137 Inferred_automatically: RNAi_primary
      WBRNAi00113086 Inferred_automatically: RNAi_primary
      WBRNAi00047093 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr6041
      Expr7955
      Expr11472
      Expr1016315
      Expr1034206
      Expr1150957
      Expr2017305
      Expr2035440
    Drives_construct: WBCnstr00002453
      WBCnstr00018685
      WBCnstr00032042
    Construct_product: WBCnstr00018685
      WBCnstr00020586
      WBCnstr00032042
    Regulate_expr_cluster: WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044656:tatn-1(qd182)_upregulated
    Microarray_results (17)
    Expression_cluster: WBPaper00032425:down_in_alg-1
      WBPaper00032425:down_in_rde-4
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038104:DATS_upregulated
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044656:tatn-1(qd182)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00045521:Gender_Neutral
      WBPaper00046795:starvation_upregulated
      WBPaper00048952:glucose_induced
      WBPaper00048988:neuron_expressed
      WBPaper00049325:CB4856_vs_N2_DEG
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:HeatShock_upregulated_hsf-1(+)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00049954:BPA_downregulated
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051265:F1_hrde-1(tm1200)_downregulated
      WBPaper00051265:F4_hrde-1(tm1200)_downregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053599:oocyte_vs_mitosis_upregulated
      WBPaper00053657:JU2519_M.humicola-infection_12hr
      WBPaper00053657:N2_M.humicola-infection_24hr
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053771:up_at_3h-NaCl
      WBPaper00055013:hmg-3(bar24)_downregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055386:daf-2(e1370)_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056039:efa-6(tm3124)_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056284:ints-11(RNAi)_downregulated
      WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057006:DietaryRestriction_downregulated
      WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
      WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium
      WBPaper00057154:HeatShock_downregulated_miRNA-target
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058711:paraquat_downregulated
      WBPaper00058711:skn-1(lax188)_upregulated
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00058955:heatshock_upregulated_CE
      WBPaper00059253:sucrose_downregulated
      WBPaper00059253:sucrose_stearic-acid_downregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059373:stt-3(RNAi)_downregulated
      WBPaper00059378:cec-4(ok3124);lmn-1(Y59C)_vs_lmn-1(Y59C)_downregulated
      WBPaper00059477:hlh-2(RNAi)_regulated
      WBPaper00059598:HeatShock_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059816:crh-1(n3315)_downrgulated
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059932:cnd-1(ju29)_downregulated
      WBPaper00059932:cnd-1(ju29)_upregulated
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060278:atp-2(RNAi)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060703:nas-38(ok3407)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ASJ
      WBPaper00061340:hyp7_C_lineage
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:saeg-1_18803-mpz-2_15880
      WBPaper00061823:mex-3(spr9)_downregulated
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_downregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_downregulated_N2
      WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
      WBPaper00062456:doxycycline_upregulated_N2_protein
      WBPaper00062590:Aging_downregulated_hypodermis
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_downregulated
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065392:Lb.delbrueckii_upregulated
      WBPaper00065392:Lb.gasseri_upregulated
      WBPaper00065746:eat-2(ad1113)_upregulated
      WBPaper00065746:tmc-1(rg1003)_upregulated
      WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:2_0
      WBPaper00065841:33_0
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00066005:RAGA-1_degradation_somatic_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066085:hda-3(ok1991)_upregulated
      WBPaper00066110:Cisplatin_upregulated_diploid
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_1_3
      cgc4489_group_1
      WBPaper00025032:PAL-1_target_genes
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00028789:PA14_vs_OP50_downregulated_4hr
      WBPaper00031003:24hr_muscle_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035227:heat_shock_regulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osmotically_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00037695:WC_5-day
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040963:Q50_down
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00044091:Bpseudomallei_induced_12h
      WBPaper00044535:male_upregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00047070:N2_UV_downregulated
      WBPaper00047070:xpa-1_UV_downregulated
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00050767:Octopamine_induced
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053550:daf-19(m86)_upregulated_L1
      WBPaper00053827:pyoverdine_upregulated
      [cgc6390]:Cluster_A
    Interaction (66)
  Map_info: Map: X Position: 21.333 Error: 0.00501
    Positive: Positive_clone: F42D1 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (11)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene