| WBGene00006987 | SMap | S_parent | Sequence | CHROMOSOME_III |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | zmp-1 | Person_evidence | WBPerson345 |
| | | Sequence_name | EGAP1.3 |
| | | Molecular_name | EGAP1.3 |
| | | | EGAP1.3.1 |
| | | | CE30930 |
| | | Other_name | CELE_EGAP1.3 | Accession_evidence | NDB | BX284603 |
| | | Public_name | zmp-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:44 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | zmp |
| | Allele (105) |
| | Legacy_information | [Kramer JM] zmp for Zinc MetalloProtease. cg115 is deletion derivative of pk205tci, no apparent phenotype. Overexpression of zmp-1 leads to abnormality, degradation of extracellular matrix components. cDNAs map to C28H8/EGAP1. Encodes predicted protein related to matrix metalloproteases. |
| | Strain | WBStrain00030910 |
| | | WBStrain00030915 |
| | | WBStrain00030928 |
| | | WBStrain00002340 |
| | | WBStrain00005036 |
| | | WBStrain00053461 |
| | | WBStrain00053459 |
| | RNASeq_FPKM (74) |
| | GO_annotation (22) |
| | Ortholog (44) |
| | Paralog | WBGene00016283 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00020646 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00019212 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00012364 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00010423 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00012185 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00010524 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00194737 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | zmp-1 encodes a zinc matrix metalloproteinase that enables anchor cell (AC) invasion during postembryonic vulval development; ZMP-1's proteinase activity has been confirmed in vitro; N-terminus to C-terminus, ZMP-1 is predicted to have a signal sequence, peptidoglycan-binding domain, a central matrix protease domain, a coiled-coil domain, and four hemopexin domains; ZMP-1 is expressed in AC during larval development, vulD and vulE in larvae and adults, and vulA in young adults onward; ZMP-1 is expressed in AC at the time it invades the basement membrane (L3 larval stage), and is localized to puncta often concentrated at the invasive basolateral membrane; ZMP-1::GFP diffuses from AC to utse cytoplasm upon fusion of these cells; ZMP-1 expression in AC requires EGL-43 (perhaps directly), and FOS-1A (indirectly); transcription of zmp-1 in AC, vulA, and vulE is driven by physically distinct sites in the zmp-1 5' flanking sequence; other regulators of ZMP-1 expression in other cell types include COG-1, EGL-38, LIN-11, LIN-29, and NHR-67; zmp-1(cg115) and zmp-1(RNAi) animals have no grossly obvious phenotypes, but null zmp-1(cg115) mutations enhance a subtle defect of AC invasion seen with null cdh-3(pk87) or him-4(rh319) mutations. | Paper_evidence (15) |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 25 Oct 2007 00:00:00 |
| | | Automated_description | Enables metallopeptidase activity. Involved in basement membrane disassembly. Located in cell surface. Expressed in several structures, including P6.paal; P6.paar; P6.papl; gonad; and vulval cell. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Is an ortholog of human MMP15 (matrix metallopeptidase 15) and MMP24 (matrix metallopeptidase 24). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7161) |
| | | DOID:2671 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7161) |
| Molecular_info | Corresponding_CDS | EGAP1.3 |
| | Corresponding_transcript | EGAP1.3.1 |
| | Associated_feature (14) |
| Experimental_info | RNAi_result | WBRNAi00028231 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00114621 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00011309 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00005962 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00076175 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00107794 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089025 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00041425 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00061775 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (13) |
| | Drives_construct (17) |
| | Construct_product | WBCnstr00004675 |
| | | WBCnstr00034050 |
| | Microarray_results (17) |
| | Expression_cluster | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_embryo_enriched |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_embryo_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040209:B.thuringiensis_downregulated_MY15 |
| | | WBPaper00042194:nhr-114(RNAi)_downregulated |
| | | WBPaper00042561:smg-2(RNAi)_upregulated |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00044030:nhr-8(hd117)_upregulated |
| | | WBPaper00044037:eat-2_regulated_nhr-62_dependent |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045861:set-2(ok952)_upregulated |
| | | WBPaper00045934:wrn-1(gk99)_downregulated |
| | | WBPaper00046012:tdp-1(ok803)_upregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h |
| | | WBPaper00046509:htz-1(ok3099)_upregulated |
| | | WBPaper00046509:lin-35(n745)_upregulated |
| | | WBPaper00048690:hermaphrodite-Z1-Z4_enriched |
| | | WBPaper00048690:male-Z1-Z4_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00050121:mir-60(n4947)_upregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050903:mir-35-41(nDf50)_25C_upregulated |
| | | WBPaper00051137:Orsay-virus_upregulated_rde-1(ne219) |
| | | WBPaper00051404:alg-1(gk214)_downregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053388:dauer_regulated_Cluster3 |
| | | WBPaper00053771:up_at_3h-NaCl |
| | | WBPaper00053771:up_at_24h-NaCl |
| | | WBPaper00053771:up_at_dpy-7(e88) |
| | | WBPaper00053810:sod-2(ok1030)_downregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055941:atfs-1(et15)_upregulated |
| | | WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056167:Cry5B_downregulated |
| | | WBPaper00056167:ifo-1(kc2)_downregulated |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_embryo |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056809:smn-1(ok355)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057143:ztf-11(RNAi)_upregulated |
| | | WBPaper00057265:metaformin_downregulated_OP50 |
| | | WBPaper00057265:metaformin_downregulated_OP50-MR |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059537:ngn-1(ok2200)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059728:5ug_cholesterol_upregulated |
| | | WBPaper00059728:20ug_cholesterol_upregulated |
| | | WBPaper00059895:wounding_upregulated |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060703:nas-38(ok3407)_upregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061081:E.faecalis_upregulated_N2 |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:BWM_anterior |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:F08G12.1_2283-cst-1_319 |
| | | WBPaper00061753:csr-1(tor159)_upregulated_25C |
| | | WBPaper00061823:mex-3(spr9)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062325:etr-1(lq61)_downregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062345:bortezomib_4h_upregulated_N2 |
| | | WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13) |
| | | WBPaper00062354:H.zoospora_6h_regulated |
| | | WBPaper00062354:H.zoospora_12h_regulated |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00062587:lsl-1(ljm1)_upregulated |
| | | WBPaper00062587:lsl-1(tm4769)_upregulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064661:lpd-3(ok2138)_upregulated |
| | | WBPaper00064735:bet-1(RNAi)_vs_N2_upregulated |
| | | WBPaper00064735:bet-1(uth41)_vs_N2_upregulated |
| | | WBPaper00064762:freezing-thaw_regulated |
| | | WBPaper00064769:him-17(me24)_upregulated |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065086:JU1400_N.ausubeli_regulated |
| | | WBPaper00065086:JU1400_N.ferruginous_regulated |
| | | WBPaper00065086:JU1400_N.ironsii_regulated |
| | | WBPaper00065086:N2_N.ausubeli_regulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065841:52_0 |
| | | WBPaper00065841:103_0 |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | WBPaper00066204:CdCl2_upregulated_mRNA |
| | | WBPaper00066232:ash-2(RNAi)_downregulated_WT |
| | | WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2 |
| | | WBPaper00066232:hsf-1(RNAi)_upregulated_WT |
| | | cgc4489_group_5 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00031003:0hr_muscle_enriched |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_2 |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00036130:mir-243_up_regulated |
| | | WBPaper00038231:Cry5B_1.5-fold_upregulated |
| | | WBPaper00038231:Cry5B_2-fold_upregulated |
| | | WBPaper00040876:mir-35_upregulated |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_prime |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00046083:ogt-1(ok1474)_OP50_downregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00056330:mrps-5(RNAi)_upregulated |
| | | [cgc6390]:Cluster_E |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction | WBInteraction000003376 |
| | | WBInteraction000003378 |
| | | WBInteraction000003667 |
| | | WBInteraction000004103 |
| | | WBInteraction000005526 |
| | | WBInteraction000005527 |
| | | WBInteraction000028301 |
| | | WBInteraction000031054 |
| | | WBInteraction000036487 |
| | | WBInteraction000052658 |
| | | WBInteraction000120136 |
| | | WBInteraction000126399 |
| | | WBInteraction000126508 |
| | | WBInteraction000126619 |
| | | WBInteraction000126620 |
| | | WBInteraction000126624 |
| | | WBInteraction000126814 |
| | | WBInteraction000132996 |
| | | WBInteraction000138070 |
| | | WBInteraction000151147 |
| | | WBInteraction000165940 |
| | | WBInteraction000166478 |
| | | WBInteraction000196908 |
| | | WBInteraction000501916 |
| | | WBInteraction000502098 |
| | | WBInteraction000502099 |
| | | WBInteraction000502100 |
| | | WBInteraction000502101 |
| | | WBInteraction000502147 |
| | | WBInteraction000502770 |
| | | WBInteraction000502892 |
| | | WBInteraction000502935 |
| | | WBInteraction000504098 |
| | | WBInteraction000504941 |
| | | WBInteraction000542203 |
| | | WBInteraction000542204 |
| | | WBInteraction000542205 |
| Map_info | Map | III | Position | -1.43269 | Error | 0.000555 |
| | Positive | Positive_clone | C28H8 |
| | | | EGAP1 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4769 |
| | Pseudo_map_position |
| Reference (38) |
| Remark | C28H8 and EGAP borders : found metalloprotease blastX matches and made gene corresponding to zmp-1,[sdm 000904] |
| | Sequence correction updated to EGAP1.3 from EGAP1.2 (this may have been an error) [krb 020717] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
