WormBase Tree Display for RNAi: WBRNAi00107794
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| WBRNAi00107794 | Homol | Homol_homol | EGAP1:RNAi | |||
|---|---|---|---|---|---|---|
| Sequence_info | PCR_product | mv_BAA28353 | ||||
| Experiment | Delivered_by | Bacterial_feeding | ||||
| Inhibits | Predicted_gene | EGAP1.5a | Inferred_automatically | RNAi_primary | ||
| EGAP1.5b | Inferred_automatically | RNAi_primary | ||||
| EGAP1.3 | Inferred_automatically | RNAi_primary | ||||
| Gene | WBGene00006987 | Inferred_automatically | RNAi_primary | |||
| WBGene00003295 | Inferred_automatically | RNAi_primary | ||||
| WBGene00271775 | Inferred_automatically | RNAi_primary | ||||
| Transcript | EGAP1.2 | Inferred_automatically | RNAi_primary | |||
| EGAP1.5b.1 | Inferred_automatically | RNAi_primary | ||||
| EGAP1.5a.1 | Inferred_automatically | RNAi_primary | ||||
| EGAP1.3.1 | Inferred_automatically | RNAi_primary | ||||
| Species | Caenorhabditis elegans | |||||
| Reference | WBPaper00045833 | |||||
| Phenotype | WBPhenotype:0000529 | Remark | "During AC invasion, the c-fos transcription factor ortholog fos-1 promotes expression the zinc metalloprotease zmp-1, the protocadherin cdh-3, the zinc finger protein egl-43, the hemicentin extracellular matrix protein gene him-4, and lamillopodin/mig-10; the activities of these genes induce the AC to form ventrally directed protrusions that breach the basement membrane (Fig 6A; Sherwood et_al, 2005; Hwang et_al 2007; Wang et_al, 2014). RNAi against the AC invasion genes resulted in defects in utse development (Table 2E; Fig 6B-D; F-H; J-L; N-P; R-T; V-X), supporting our hypothesis that genes involved in AC protrusion formation also affect utse development." | |||
| Penetrance | Incomplete | |||||
| Range | 63 | |||||
| EQ_annotations | Anatomy_term | WBbt:0006789 | PATO:0000460 | |||
| Remark | (Table 2, Figure 6) zmp-1 RNAi | |||||
| Method | RNAi |
