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WormBase Tree Display for Gene: WBGene00006987

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Name Class

WBGene00006987SMapS_parentSequenceCHROMOSOME_III
IdentityVersion1
NameCGC_namezmp-1Person_evidenceWBPerson345
Sequence_nameEGAP1.3
Molecular_nameEGAP1.3
EGAP1.3.1
CE30930
Other_nameCELE_EGAP1.3Accession_evidenceNDBBX284603
Public_namezmp-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:44WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classzmp
Allele (105)
Legacy_information[Kramer JM] zmp for Zinc MetalloProtease. cg115 is deletion derivative of pk205tci, no apparent phenotype. Overexpression of zmp-1 leads to abnormality, degradation of extracellular matrix components. cDNAs map to C28H8/EGAP1. Encodes predicted protein related to matrix metalloproteases.
StrainWBStrain00030910
WBStrain00030915
WBStrain00030928
WBStrain00002340
WBStrain00005036
WBStrain00053461
WBStrain00053459
RNASeq_FPKM (74)
GO_annotation (22)
Ortholog (44)
ParalogWBGene00016283Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00020646Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00019212Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00012364Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00010423Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00012185Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00010524Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00194737Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionzmp-1 encodes a zinc matrix metalloproteinase that enables anchor cell (AC) invasion during postembryonic vulval development; ZMP-1's proteinase activity has been confirmed in vitro; N-terminus to C-terminus, ZMP-1 is predicted to have a signal sequence, peptidoglycan-binding domain, a central matrix protease domain, a coiled-coil domain, and four hemopexin domains; ZMP-1 is expressed in AC during larval development, vulD and vulE in larvae and adults, and vulA in young adults onward; ZMP-1 is expressed in AC at the time it invades the basement membrane (L3 larval stage), and is localized to puncta often concentrated at the invasive basolateral membrane; ZMP-1::GFP diffuses from AC to utse cytoplasm upon fusion of these cells; ZMP-1 expression in AC requires EGL-43 (perhaps directly), and FOS-1A (indirectly); transcription of zmp-1 in AC, vulA, and vulE is driven by physically distinct sites in the zmp-1 5' flanking sequence; other regulators of ZMP-1 expression in other cell types include COG-1, EGL-38, LIN-11, LIN-29, and NHR-67; zmp-1(cg115) and zmp-1(RNAi) animals have no grossly obvious phenotypes, but null zmp-1(cg115) mutations enhance a subtle defect of AC invasion seen with null cdh-3(pk87) or him-4(rh319) mutations.Paper_evidence (15)
Curator_confirmedWBPerson567
Date_last_updated25 Oct 2007 00:00:00
Automated_descriptionEnables metallopeptidase activity. Involved in basement membrane disassembly. Located in cell surface. Expressed in several structures, including P6.paal; P6.paar; P6.papl; gonad; and vulval cell. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Is an ortholog of human MMP15 (matrix metallopeptidase 15) and MMP24 (matrix metallopeptidase 24).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:10283Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7161)
DOID:2671Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7161)
Molecular_infoCorresponding_CDSEGAP1.3
Corresponding_transcriptEGAP1.3.1
Associated_feature (14)
Experimental_infoRNAi_resultWBRNAi00028231Inferred_automaticallyRNAi_primary
WBRNAi00114621Inferred_automaticallyRNAi_primary
WBRNAi00011309Inferred_automaticallyRNAi_primary
WBRNAi00005962Inferred_automaticallyRNAi_primary
WBRNAi00076175Inferred_automaticallyRNAi_primary
WBRNAi00107794Inferred_automaticallyRNAi_primary
WBRNAi00089025Inferred_automaticallyRNAi_primary
WBRNAi00041425Inferred_automaticallyRNAi_primary
WBRNAi00061775Inferred_automaticallyRNAi_primary
Expr_pattern (13)
Drives_construct (17)
Construct_productWBCnstr00004675
WBCnstr00034050
Microarray_results (17)
Expression_cluster (174)
Interaction (37)
Map_infoMapIIIPosition-1.43269Error0.000555
PositivePositive_cloneC28H8
EGAP1Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4769
Pseudo_map_position
Reference (38)
RemarkC28H8 and EGAP borders : found metalloprotease blastX matches and made gene corresponding to zmp-1,[sdm 000904]
Sequence correction updated to EGAP1.3 from EGAP1.2 (this may have been an error) [krb 020717]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene