WormBase Tree Display for Gene: WBGene00006351

WBGene00006351 SMap: S_parent: Sequence: K03A1
  Identity: Version: 1
    Name: CGC_name: sur-5 Person_evidence: WBPerson237
      Sequence_name: K03A1.5
      Molecular_name: K03A1.5
        K03A1.5.1
        CE04713
      Other_name: CELE_K03A1.5 Accession_evidence: NDB BX284606
      Public_name: sur-5
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:40 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sur
    Allele (86)
    Legacy_information: [Gu T] sur-5 for suppressors of ras. Mutations in sur-5 suppress the vulvaless phenotype caused by let-60(sy94) dominant negative mutation. sur-5 mutations have no phenotype on their own.
    Complementation_data: [Gu T] ku74 failed to complement uDf1
    Strain: WBStrain00005188
      WBStrain00026507
      WBStrain00004760
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog (44)
    Paralog: WBGene00007969 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00009221 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00012356 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00013440 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00016849 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00018269 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00018488 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00018579 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: sur-5 encodes a protein with high similarity to H. sapiens Acetoacetyl-coenzyme A synthetase; sur-5 negatively regulates let-60 during vulval induction, based on genetic analysis, and genetically synergises with lin-45 with respect to larval death, uncoordinated movement and egg-laying defects; sur-5 is strongly expressed in most cells of C. elegans, including the VPCs, and is localized primarily to the nucleus. Paper_evidence: WBPaper00003142
          Curator_confirmed: WBPerson48
          Date_last_updated: 14 Jul 2005 00:00:00
      Automated_description: Predicted to enable acetoacetate-CoA ligase activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; gonad; hypodermal cell; and somatic cell. Is an ortholog of human AACS (acetoacetyl-CoA synthetase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: K03A1.5
    Corresponding_transcript: K03A1.5.1
    Other_sequence (38)
    Associated_feature: WBsf670020
      WBsf982195
      WBsf1005800
      WBsf1023223
      WBsf237562
      WBsf237563
      WBsf237564
      WBsf237565
      WBsf237566
  Experimental_info: RNAi_result: WBRNAi00087230 Inferred_automatically: RNAi_primary
      WBRNAi00049782 Inferred_automatically: RNAi_primary
      WBRNAi00000452 Inferred_automatically: RNAi_primary
      WBRNAi00016506 Inferred_automatically: RNAi_primary
      WBRNAi00033903 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1340
      Expr1416
      Expr12760
      Expr1027579
      Expr1032558
      Expr1153497
      Expr2017136
      Expr2035272
    Drives_construct (78)
    Construct_product: WBCnstr00006929
      WBCnstr00007155
      WBCnstr00016061
      WBCnstr00016065
      WBCnstr00023091
      WBCnstr00034394
      WBCnstr00042119
    Microarray_results (21)
    Expression_cluster: WBPaper00029359_1280
      WBPaper00029359_1289
      WBPaper00029359_1304
      WBPaper00029359_1444
      WBPaper00029359_1497
      WBPaper00029359_1504
      WBPaper00029359_1604
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037950:all-neurons_larva_enriched
      WBPaper00037950:bodywall-muscle_larva_enriched
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_larva_enriched
      WBPaper00038357:atx-3_regulated_heat-shock
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040134:nhr-49(RNAi)_regulated_protein
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_downregulated_Day5
      WBPaper00044746:aging_downregulated_HeatShock
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_downregulated_protein
      WBPaper00046795:starvation_downregulated
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049334:CE_intestine_enriched
      WBPaper00049495:starvation-refeeding_regulated
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049905:Age_variant_expression
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051257:Levamisole_downregulated
      WBPaper00051305:vit-2(ac3)_downregulated
      WBPaper00051371:Orsay-virus-infection_downregulated_rde-1(ne219)
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053615:SMO-1_target
      WBPaper00053814:25C_upregulated_PY79
      WBPaper00054192:cold-shock_downregulated
      WBPaper00054913:AKIR-1_interacting_protein
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:atfs-1(et15)_downregulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056034:pals-25(jy9)_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00056997:NMAD-1_interacting
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059117:B.subtilis_downregulated
      WBPaper00059254:CSR-1_interacting
      WBPaper00059328:mrps-5(RNAi)_downregulated_protein
      WBPaper00059426:Ag-nanoparticles_upregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059605:MUT-16_interacting
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00059895:wounding_downregulated
      WBPaper00059987:Wounding_downregulated
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_N2
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_downregulated_CoCl2_6hr
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060703:nas-38(ok3407)_downregulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061040:FW1256_upregulated
      WBPaper00061081:E.faecalis_downregulated_N2
      WBPaper00061081:E.faecalis_downregulated_skpo-1(ok1640)
      WBPaper00061340:RIH
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:gst-26-pho-1_10767
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061818:AFD_enriched_protein
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:daf-16(RNAi)_upregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062345:bortezomib_4h_downregulated_N2
      WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
      WBPaper00062440:crh-1(n3315)_upregulated
      WBPaper00062440:crh-1(syb385)_upregulated
      WBPaper00062456:doxycycline_upregulated_CB4856_protein
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00062684:pathogen_downregulated_N2
      WBPaper00064005:starvation_upregulated_N2_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064156:lipl-4(overexpress)_downregulated
      WBPaper00064163:ZNFX-1_interacting_embryo
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064315:mes-3(bn199)_upregulated_PGCs
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064315:mes-4(bn73)_upregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064637:cox-5B(RNAi)_upregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064728:cpl-1(W32AY35A)_upregulated
      WBPaper00064789:Day3_vs_Day1_downregulated_neuron
      WBPaper00064789:Day6_vs_Day1_downregulated_neuron
      WBPaper00064789:Day9_vs_Day1_downregulated_neuron
      WBPaper00064789:Day12_vs_Day1_downregulated_neuron
      WBPaper00064871:hypoxia_upregulated_F1
      WBPaper00064871:PA14_downregulated_AWA
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065086:JU1400_N.ironsii_regulated
      WBPaper00065086:N2_N.ausubeli_regulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065158:AFD_depleted
      WBPaper00065225:nhr-42(tm1375)_downregulated_S.aureus-infected
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065373:sek-1(km4)_downregulated_Ref
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066085:sin-3(syb2172)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066232:hsf-1(RNAi)_downregulated_WT
      cgc4386_cluster_1_1
      cgc4489_group_3
      WBPaper00025032:cluster_80
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_N2
      WBPaper00028789:PA14_vs_OP50_downregulated_4hr
      WBPaper00028789:PA14_vs_OP50_downregulated_8hr
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00032062:age_regulated_genes
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035873:osm-11_regulated
      WBPaper00036286:Pattern_C
      WBPaper00036464:S.aureus-RN6390_regulated
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038231:Cry5B_2-fold_downregulated
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.5
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040963:Q50_up
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00040963:TA100_down
      WBPaper00040963:TA200_down
      WBPaper00040963:TA300_down
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00045673:colistin_upregulated
      WBPaper00047021:MWCNT_upregulated
      WBPaper00047070:N2_UV_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00055435:MUA-AuNP-0.5_upregulated
      WBPaper00055435:MUA-AuNP-3_upregulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc5376]:let-60(G12V)-regulated_genes
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
    Interaction (89)
    WBProcess: WBbiopr:00000071
  Map_info: Map: X Position: -1.78093 Error: 0.00152
    Well_ordered
    Positive: Inside_rearr: uDf1
      Positive_clone: K03A1 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3553
        4679
      Pos_neg_data: 9150
  Reference (39)
  Remark: sur-5 is located on a 8kb BamHI fragment that overlaps both K03A1 and R12E12. R12E12 also rescues ku74. The allele ku74 is a inframe deletion that deletes 295 n.t. of the sur-5 genomic sequence.
  Method: Gene