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WormBase Tree Display for Gene: WBGene00009221

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Name Class

WBGene00009221SMapS_parentSequenceF28F8
IdentityVersion2
NameCGC_nameacs-2Person_evidenceWBPerson7030
WBPerson2239
WBPerson237
Sequence_nameF28F8.2
Molecular_nameF28F8.2
F28F8.2.1
CE09756
Other_nameCELE_F28F8.2Accession_evidenceNDBBX284605
Public_nameacs-2
DB_infoDatabaseAceViewgene5Q49
WormQTLgeneWBGene00009221
WormFluxgeneWBGene00009221
NDBlocus_tagCELE_F28F8.2
PanthergeneCAEEL|WormBase=WBGene00009221|UniProtKB=O18693
familyPTHR43201
NCBIgene3565680
RefSeqproteinNM_074468.6
TREEFAMTREEFAM_IDTF313466
TrEMBLUniProtAccO18693
UniProt_GCRPUniProtAccO18693
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:50WBPerson1971EventImportedInitial conversion from CDS class of WS125
223 Mar 2005 15:36:05WBPerson2970Name_changeCGC_nameacs-2
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classacs
Allele (76)
StrainWBStrain00032584
Component_of_genotypeWBGenotype00000151
WBGenotype00000152
WBGenotype00000153
WBGenotype00000154
RNASeq_FPKM (74)
GO_annotation00031987
00031988
00031989
00031990
Ortholog (38)
ParalogWBGene00016849Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00018269Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00018579Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00018488Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006351Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00007969Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00012356Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00013440Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionacs-2 encodes an acyl-CoA synthetase; by homology, ACS-2 is predicted to catalyze conversion of a fatty acid to Acyl-CoA for subsequent beta oxidation; accordingly, loss of acs-2 activity via RNAi results in defects in fat metabolism; an ACS-2::GFP reporter fusion protein is widely expressed and appears to localize to mitochondria; acs-2 expression is positively regulated by the NHR-49 nuclear hormone receptor.Paper_evidenceWBPaper00005655
WBPaper00025114
Curator_confirmedWBPerson1843
Date_last_updated17 Mar 2009 00:00:00
Automated_descriptionPredicted to enable medium-chain fatty acid-CoA ligase activity. Involved in fatty acid metabolic process. Located in mitochondrion. Expressed in body wall musculature; hypodermis; intestine; neurons; and pharynx. Is an ortholog of human ACSF2 (acyl-CoA synthetase family member 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:3146Homo sapiensPaper_evidenceWBPaper00039810
Curator_confirmedWBPerson324
Date_last_updated31 Jul 2023 00:00:00
Molecular_infoCorresponding_CDSF28F8.2
Corresponding_transcriptF28F8.2.1
Other_sequence (21)
Associated_featureWBsf662130
WBsf1002313
WBsf1021034
WBsf233036
Experimental_infoRNAi_result (11)
Expr_patternExpr3469
Expr3780
Expr1014898
Expr1034024
Expr1149753
Expr2009213
Expr2027450
Drives_constructWBCnstr00011406
WBCnstr00011655
WBCnstr00021644
Construct_productWBCnstr00011406
WBCnstr00011655
Microarray_results (25)
Expression_cluster (473)
Interaction (73)
Map_infoMapVPosition8.35712Error0.005311
PositivePositive_cloneF28F8Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (52)
PictureWBPicture0000013098
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene