WormBase Tree Display for Gene: WBGene00000898
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WBGene00000898 | SMap | S_parent | Sequence | Y55D5A | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | daf-2 | Person_evidence | WBPerson521 | |||||
Sequence_name | Y55D5A.5 | ||||||||
Molecular_name (19) | |||||||||
Other_name | CELE_Y55D5A.5 | Accession_evidence | NDB | BX284603 | |||||
Public_name | daf-2 | ||||||||
DB_info | Database (14) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info (12) | |||||||||
Disease_info | Experimental_model | DOID:9351 | Homo sapiens | Paper_evidence | WBPaper00064218 | ||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 07 Nov 2022 00:00:00 | ||||||||
DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00045313 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 26 Jan 2015 00:00:00 | ||||||||
Potential_model (37) | |||||||||
Disease_relevance | Parkinson''s disease (PD) is an age-dependent neurodegenerative disease characterized by the accumulation of alpha-synuclein (alpha-syn) and the selective loss of dopamine (DA) neurons; studies in C. elegans models of alpha-syn proteotoxcity indicate that reduced IGF-1/insulin-like signaling (IIS) suppresses alpha-syn toxicity and DA neurodegeneration; specifically daf-2 mutant worms that overexpress human alpha-syn retain more wild-type DA neurons when compared to alpha-syn worms alone; mutants of daf-16/FOXO, a well-characterized downstream component of the IIS pathway enhanced neurodegeneration, and an intermediate level of neuroprotection was seen in daf-2; daf-16 double mutants overexpressing alpha-syn-GFP in DA neurons; further, RNA interference of glucose-6-phosphate isomerase (gpi-1/GPI), the glycolytic enzyme, enhanced alpha-syn-induced DA neurotoxicity, while it''s overexpression in DA neurons was neuroprotective; further studies in Drosophila and mice confirm that GPI is neuroprotective; these studies indicate that IIS signaling modulates alpha-syn induced DA neurodegeneration, across species. | Homo sapiens | Paper_evidence | WBPaper00045313 | |||||
WBPaper00025083 | |||||||||
WBPaper00031384 | |||||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 26 Jan 2015 00:00:00 | ||||||||
In glucose-fed wild-type animals, the exponential like decline was restored in the active state, indicating that insulin signaling may be involved in regulation of fractal scaling of C. elegans behavior. | Homo sapiens | Curator_confirmed | WBPerson324 | ||||||
Models_disease_in_annotation | WBDOannot00000339 | ||||||||
Models_disease_asserted | WBDOannot00001356 | ||||||||
Molecular_info | Corresponding_CDS | Y55D5A.5a | |||||||
Y55D5A.5c | |||||||||
Y55D5A.5d | |||||||||
Y55D5A.5e | |||||||||
Y55D5A.5f | |||||||||
Y55D5A.5g | |||||||||
Corresponding_CDS_history | Y55D5A.5:wp187 | ||||||||
Y55D5A.5a:wp229 | |||||||||
Y55D5A.5b:wp229 | |||||||||
Y55D5A.5b:wp247 | |||||||||
Corresponding_transcript | Y55D5A.5b | ||||||||
Y55D5A.5a.1 | |||||||||
Y55D5A.5c.1 | |||||||||
Y55D5A.5d.1 | |||||||||
Y55D5A.5e.1 | |||||||||
Y55D5A.5f.1 | |||||||||
Y55D5A.5g.1 | |||||||||
Other_sequence (112) | |||||||||
Associated_feature (24) | |||||||||
Experimental_info | RNAi_result | WBRNAi00098353 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00098394 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084803 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00095301 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00086139 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00107051 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084308 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00088013 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00093629 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00079036 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084700 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00078887 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00078209 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00109289 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00102279 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00067473 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00069847 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00098354 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00102719 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00102716 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00098396 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00080805 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00098027 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00109191 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084294 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00098401 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00102858 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00069850 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00086039 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00095353 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00066316 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097395 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00103059 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00078529 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097387 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00095356 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00077763 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00092436 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00098029 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00063892 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00102051 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00066516 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00093319 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00064000 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084331 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00112257 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00077707 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00098395 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00086040 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00102866 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00109580 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00109483 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00102861 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00109386 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00112270 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097388 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00088022 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00089387 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00066265 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097396 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00069848 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00062551 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00113592 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00066137 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00086735 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00066518 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00067262 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00102864 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00089393 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00066319 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00098352 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00093628 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00078669 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00078086 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00092073 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00108164 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084922 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00066202 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084312 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00087375 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00098397 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097393 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00092072 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00091894 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00078605 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00081713 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097932 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084301 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00057515 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00112271 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097392 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00087396 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00098402 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097389 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00063123 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00062549 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00077765 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00088014 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00102717 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084302 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00102275 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084314 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00088026 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00102827 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00091896 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00092435 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00091864 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00102053 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00091895 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00021017 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097385 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00069849 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00066517 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097031 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00092787 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00092438 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084802 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00091887 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097394 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00091965 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00081714 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084923 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097384 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00088011 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00063999 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00092519 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00095355 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00102718 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00102799 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00066317 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00091898 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00098026 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00102280 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00087374 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00107943 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00088012 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00087401 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00102826 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097030 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00076000 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00075694 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097386 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084323 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00117265 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00111968 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00102806 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097391 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00091861 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00098028 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00084297 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00106243 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00091880 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00066221 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00102327 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00091899 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00062550 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (22) | |||||||||
Drives_construct | WBCnstr00003380 | ||||||||
WBCnstr00019426 | |||||||||
WBCnstr00039941 | |||||||||
WBCnstr00042486 | |||||||||
WBCnstr00042487 | |||||||||
Construct_product (25) | |||||||||
Regulate_expr_cluster (58) | |||||||||
Antibody | WBAntibody00002296 | ||||||||
WBAntibody00003034 | |||||||||
Microarray_results (31) | |||||||||
Expression_cluster (126) | |||||||||
Interaction (1462) | |||||||||
Anatomy_function | WBbtf0101 | ||||||||
WBbtf0102 | |||||||||
WBbtf0103 | |||||||||
WBProcess | WBbiopr:00000001 | ||||||||
WBbiopr:00000008 | |||||||||
WBbiopr:00000025 | |||||||||
WBbiopr:00000039 | |||||||||
WBbiopr:00000052 | |||||||||
WBbiopr:00000061 | |||||||||
WBbiopr:00000065 | |||||||||
WBbiopr:00000074 | |||||||||
WBbiopr:00000096 | |||||||||
WBbiopr:00000121 | |||||||||
Map_info | Map | III | Position | -8.03413 | Error | 0.111365 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | nDf11 | |||||||
Positive_clone | C44B11 | ||||||||
H05C05 | |||||||||
Y55D5A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
Negative | Outside_rearr | tDf9 | |||||||
Mapping_data | 2_point | 273 | |||||||
411 | |||||||||
412 | |||||||||
7053 | |||||||||
Multi_point (23) | |||||||||
Pos_neg_data (12) | |||||||||
Reference (1726) | |||||||||
Picture | WBPicture0000013078 | ||||||||
WBPicture0000013087 | |||||||||
Method | Gene |