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WormBase Tree Display for Gene: WBGene00000898

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Name Class

WBGene00000898SMapS_parentSequenceY55D5A
IdentityVersion1
NameCGC_namedaf-2Person_evidenceWBPerson521
Sequence_nameY55D5A.5
Molecular_name (19)
Other_nameCELE_Y55D5A.5Accession_evidenceNDBBX284603
Public_namedaf-2
DB_infoDatabase (14)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:21WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_info (12)
Disease_infoExperimental_modelDOID:9351Homo sapiensPaper_evidenceWBPaper00064218
Curator_confirmedWBPerson324
Date_last_updated07 Nov 2022 00:00:00
DOID:14330Homo sapiensPaper_evidenceWBPaper00045313
Curator_confirmedWBPerson324
Date_last_updated26 Jan 2015 00:00:00
Potential_model (37)
Disease_relevanceParkinson''s disease (PD) is an age-dependent neurodegenerative disease characterized by the accumulation of alpha-synuclein (alpha-syn) and the selective loss of dopamine (DA) neurons; studies in C. elegans models of alpha-syn proteotoxcity indicate that reduced IGF-1/insulin-like signaling (IIS) suppresses alpha-syn toxicity and DA neurodegeneration; specifically daf-2 mutant worms that overexpress human alpha-syn retain more wild-type DA neurons when compared to alpha-syn worms alone; mutants of daf-16/FOXO, a well-characterized downstream component of the IIS pathway enhanced neurodegeneration, and an intermediate level of neuroprotection was seen in daf-2; daf-16 double mutants overexpressing alpha-syn-GFP in DA neurons; further, RNA interference of glucose-6-phosphate isomerase (gpi-1/GPI), the glycolytic enzyme, enhanced alpha-syn-induced DA neurotoxicity, while it''s overexpression in DA neurons was neuroprotective; further studies in Drosophila and mice confirm that GPI is neuroprotective; these studies indicate that IIS signaling modulates alpha-syn induced DA neurodegeneration, across species.Homo sapiensPaper_evidenceWBPaper00045313
WBPaper00025083
WBPaper00031384
Curator_confirmedWBPerson324
Date_last_updated26 Jan 2015 00:00:00
In glucose-fed wild-type animals, the exponential like decline was restored in the active state, indicating that insulin signaling may be involved in regulation of fractal scaling of C. elegans behavior.Homo sapiensCurator_confirmedWBPerson324
Models_disease_in_annotationWBDOannot00000339
Models_disease_assertedWBDOannot00001356
Molecular_infoCorresponding_CDSY55D5A.5a
Y55D5A.5c
Y55D5A.5d
Y55D5A.5e
Y55D5A.5f
Y55D5A.5g
Corresponding_CDS_historyY55D5A.5:wp187
Y55D5A.5a:wp229
Y55D5A.5b:wp229
Y55D5A.5b:wp247
Corresponding_transcriptY55D5A.5b
Y55D5A.5a.1
Y55D5A.5c.1
Y55D5A.5d.1
Y55D5A.5e.1
Y55D5A.5f.1
Y55D5A.5g.1
Other_sequence (112)
Associated_feature (24)
Experimental_infoRNAi_resultWBRNAi00098353Inferred_automaticallyRNAi_primary
WBRNAi00098394Inferred_automaticallyRNAi_primary
WBRNAi00084803Inferred_automaticallyRNAi_primary
WBRNAi00095301Inferred_automaticallyRNAi_primary
WBRNAi00086139Inferred_automaticallyRNAi_primary
WBRNAi00107051Inferred_automaticallyRNAi_primary
WBRNAi00084308Inferred_automaticallyRNAi_primary
WBRNAi00088013Inferred_automaticallyRNAi_primary
WBRNAi00093629Inferred_automaticallyRNAi_primary
WBRNAi00079036Inferred_automaticallyRNAi_primary
WBRNAi00084700Inferred_automaticallyRNAi_primary
WBRNAi00078887Inferred_automaticallyRNAi_primary
WBRNAi00078209Inferred_automaticallyRNAi_primary
WBRNAi00109289Inferred_automaticallyRNAi_primary
WBRNAi00102279Inferred_automaticallyRNAi_primary
WBRNAi00067473Inferred_automaticallyRNAi_primary
WBRNAi00069847Inferred_automaticallyRNAi_primary
WBRNAi00098354Inferred_automaticallyRNAi_primary
WBRNAi00102719Inferred_automaticallyRNAi_primary
WBRNAi00102716Inferred_automaticallyRNAi_primary
WBRNAi00098396Inferred_automaticallyRNAi_primary
WBRNAi00080805Inferred_automaticallyRNAi_primary
WBRNAi00098027Inferred_automaticallyRNAi_primary
WBRNAi00109191Inferred_automaticallyRNAi_primary
WBRNAi00084294Inferred_automaticallyRNAi_primary
WBRNAi00098401Inferred_automaticallyRNAi_primary
WBRNAi00102858Inferred_automaticallyRNAi_primary
WBRNAi00069850Inferred_automaticallyRNAi_primary
WBRNAi00086039Inferred_automaticallyRNAi_primary
WBRNAi00095353Inferred_automaticallyRNAi_primary
WBRNAi00066316Inferred_automaticallyRNAi_primary
WBRNAi00097395Inferred_automaticallyRNAi_primary
WBRNAi00103059Inferred_automaticallyRNAi_primary
WBRNAi00078529Inferred_automaticallyRNAi_primary
WBRNAi00097387Inferred_automaticallyRNAi_primary
WBRNAi00095356Inferred_automaticallyRNAi_primary
WBRNAi00077763Inferred_automaticallyRNAi_primary
WBRNAi00092436Inferred_automaticallyRNAi_primary
WBRNAi00098029Inferred_automaticallyRNAi_primary
WBRNAi00063892Inferred_automaticallyRNAi_primary
WBRNAi00102051Inferred_automaticallyRNAi_primary
WBRNAi00066516Inferred_automaticallyRNAi_primary
WBRNAi00093319Inferred_automaticallyRNAi_primary
WBRNAi00064000Inferred_automaticallyRNAi_primary
WBRNAi00084331Inferred_automaticallyRNAi_primary
WBRNAi00112257Inferred_automaticallyRNAi_primary
WBRNAi00077707Inferred_automaticallyRNAi_primary
WBRNAi00098395Inferred_automaticallyRNAi_primary
WBRNAi00086040Inferred_automaticallyRNAi_primary
WBRNAi00102866Inferred_automaticallyRNAi_primary
WBRNAi00109580Inferred_automaticallyRNAi_primary
WBRNAi00109483Inferred_automaticallyRNAi_primary
WBRNAi00102861Inferred_automaticallyRNAi_primary
WBRNAi00109386Inferred_automaticallyRNAi_primary
WBRNAi00112270Inferred_automaticallyRNAi_primary
WBRNAi00097388Inferred_automaticallyRNAi_primary
WBRNAi00088022Inferred_automaticallyRNAi_primary
WBRNAi00089387Inferred_automaticallyRNAi_primary
WBRNAi00066265Inferred_automaticallyRNAi_primary
WBRNAi00097396Inferred_automaticallyRNAi_primary
WBRNAi00069848Inferred_automaticallyRNAi_primary
WBRNAi00062551Inferred_automaticallyRNAi_primary
WBRNAi00113592Inferred_automaticallyRNAi_primary
WBRNAi00066137Inferred_automaticallyRNAi_primary
WBRNAi00086735Inferred_automaticallyRNAi_primary
WBRNAi00066518Inferred_automaticallyRNAi_primary
WBRNAi00067262Inferred_automaticallyRNAi_primary
WBRNAi00102864Inferred_automaticallyRNAi_primary
WBRNAi00089393Inferred_automaticallyRNAi_primary
WBRNAi00066319Inferred_automaticallyRNAi_primary
WBRNAi00098352Inferred_automaticallyRNAi_primary
WBRNAi00093628Inferred_automaticallyRNAi_primary
WBRNAi00078669Inferred_automaticallyRNAi_primary
WBRNAi00078086Inferred_automaticallyRNAi_primary
WBRNAi00092073Inferred_automaticallyRNAi_primary
WBRNAi00108164Inferred_automaticallyRNAi_primary
WBRNAi00084922Inferred_automaticallyRNAi_primary
WBRNAi00066202Inferred_automaticallyRNAi_primary
WBRNAi00084312Inferred_automaticallyRNAi_primary
WBRNAi00087375Inferred_automaticallyRNAi_primary
WBRNAi00098397Inferred_automaticallyRNAi_primary
WBRNAi00097393Inferred_automaticallyRNAi_primary
WBRNAi00092072Inferred_automaticallyRNAi_primary
WBRNAi00091894Inferred_automaticallyRNAi_primary
WBRNAi00078605Inferred_automaticallyRNAi_primary
WBRNAi00081713Inferred_automaticallyRNAi_primary
WBRNAi00097932Inferred_automaticallyRNAi_primary
WBRNAi00084301Inferred_automaticallyRNAi_primary
WBRNAi00057515Inferred_automaticallyRNAi_primary
WBRNAi00112271Inferred_automaticallyRNAi_primary
WBRNAi00097392Inferred_automaticallyRNAi_primary
WBRNAi00087396Inferred_automaticallyRNAi_primary
WBRNAi00098402Inferred_automaticallyRNAi_primary
WBRNAi00097389Inferred_automaticallyRNAi_primary
WBRNAi00063123Inferred_automaticallyRNAi_primary
WBRNAi00062549Inferred_automaticallyRNAi_primary
WBRNAi00077765Inferred_automaticallyRNAi_primary
WBRNAi00088014Inferred_automaticallyRNAi_primary
WBRNAi00102717Inferred_automaticallyRNAi_primary
WBRNAi00084302Inferred_automaticallyRNAi_primary
WBRNAi00102275Inferred_automaticallyRNAi_primary
WBRNAi00084314Inferred_automaticallyRNAi_primary
WBRNAi00088026Inferred_automaticallyRNAi_primary
WBRNAi00102827Inferred_automaticallyRNAi_primary
WBRNAi00091896Inferred_automaticallyRNAi_primary
WBRNAi00092435Inferred_automaticallyRNAi_primary
WBRNAi00091864Inferred_automaticallyRNAi_primary
WBRNAi00102053Inferred_automaticallyRNAi_primary
WBRNAi00091895Inferred_automaticallyRNAi_primary
WBRNAi00021017Inferred_automaticallyRNAi_primary
WBRNAi00097385Inferred_automaticallyRNAi_primary
WBRNAi00069849Inferred_automaticallyRNAi_primary
WBRNAi00066517Inferred_automaticallyRNAi_primary
WBRNAi00097031Inferred_automaticallyRNAi_primary
WBRNAi00092787Inferred_automaticallyRNAi_primary
WBRNAi00092438Inferred_automaticallyRNAi_primary
WBRNAi00084802Inferred_automaticallyRNAi_primary
WBRNAi00091887Inferred_automaticallyRNAi_primary
WBRNAi00097394Inferred_automaticallyRNAi_primary
WBRNAi00091965Inferred_automaticallyRNAi_primary
WBRNAi00081714Inferred_automaticallyRNAi_primary
WBRNAi00084923Inferred_automaticallyRNAi_primary
WBRNAi00097384Inferred_automaticallyRNAi_primary
WBRNAi00088011Inferred_automaticallyRNAi_primary
WBRNAi00063999Inferred_automaticallyRNAi_primary
WBRNAi00092519Inferred_automaticallyRNAi_primary
WBRNAi00095355Inferred_automaticallyRNAi_primary
WBRNAi00102718Inferred_automaticallyRNAi_primary
WBRNAi00102799Inferred_automaticallyRNAi_primary
WBRNAi00066317Inferred_automaticallyRNAi_primary
WBRNAi00091898Inferred_automaticallyRNAi_primary
WBRNAi00098026Inferred_automaticallyRNAi_primary
WBRNAi00102280Inferred_automaticallyRNAi_primary
WBRNAi00087374Inferred_automaticallyRNAi_primary
WBRNAi00107943Inferred_automaticallyRNAi_primary
WBRNAi00088012Inferred_automaticallyRNAi_primary
WBRNAi00087401Inferred_automaticallyRNAi_primary
WBRNAi00102826Inferred_automaticallyRNAi_primary
WBRNAi00097030Inferred_automaticallyRNAi_primary
WBRNAi00076000Inferred_automaticallyRNAi_primary
WBRNAi00075694Inferred_automaticallyRNAi_primary
WBRNAi00097386Inferred_automaticallyRNAi_primary
WBRNAi00084323Inferred_automaticallyRNAi_primary
WBRNAi00117265Inferred_automaticallyRNAi_primary
WBRNAi00111968Inferred_automaticallyRNAi_primary
WBRNAi00102806Inferred_automaticallyRNAi_primary
WBRNAi00097391Inferred_automaticallyRNAi_primary
WBRNAi00091861Inferred_automaticallyRNAi_primary
WBRNAi00098028Inferred_automaticallyRNAi_primary
WBRNAi00084297Inferred_automaticallyRNAi_primary
WBRNAi00106243Inferred_automaticallyRNAi_primary
WBRNAi00091880Inferred_automaticallyRNAi_primary
WBRNAi00066221Inferred_automaticallyRNAi_primary
WBRNAi00102327Inferred_automaticallyRNAi_primary
WBRNAi00091899Inferred_automaticallyRNAi_primary
WBRNAi00062550Inferred_automaticallyRNAi_primary
Expr_pattern (22)
Drives_constructWBCnstr00003380
WBCnstr00019426
WBCnstr00039941
WBCnstr00042486
WBCnstr00042487
Construct_product (25)
Regulate_expr_cluster (58)
AntibodyWBAntibody00002296
WBAntibody00003034
Microarray_results (31)
Expression_cluster (126)
Interaction (1462)
Anatomy_functionWBbtf0101
WBbtf0102
WBbtf0103
WBProcessWBbiopr:00000001
WBbiopr:00000008
WBbiopr:00000025
WBbiopr:00000039
WBbiopr:00000052
WBbiopr:00000061
WBbiopr:00000065
WBbiopr:00000074
WBbiopr:00000096
WBbiopr:00000121
Map_infoMapIIIPosition-8.03413Error0.111365
Well_ordered
PositiveInside_rearrnDf11
Positive_cloneC44B11
H05C05
Y55D5AInferred_automaticallyFrom sequence, transcript, pseudogene data
NegativeOutside_rearrtDf9
Mapping_data2_point273
411
412
7053
Multi_point (23)
Pos_neg_data (12)
Reference (1726)
PictureWBPicture0000013078
WBPicture0000013087
MethodGene