WormBase Tree Display for RNAi: WBRNAi00066319
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| WBRNAi00066319 | Homol | Homol_homol | Y55D5A:RNAi | ||
|---|---|---|---|---|---|
| Sequence_info | DNA_text | atgaatattgtcagatgtcggagacgacacaaaattttggaaaatttggaagaagagaatctcggcccgagctgctcgtcgacgacttcaacaaccgctgccaccgaagctctcggaacaaccactgaggatatgaggcttaagcagcagcgaagctcgtcgcgtgccacggagcacgatattgtcgacggcaatcaccacgacgacgagcacatcacaatgagacggcttcgacttgtcaaaaattcgcggacgcggcgtagaacgacgcccgattcaagtatggactgctatgaggaaaacccgccatcacaaaaaacttcaataaattattcttggatttctaaaaagtcatcaatgacgtcattaatgcttttactgctattcgcttttgtacagccgtgtgcctcaatagtcgaaaaacgatgcggcccaatcgatattcgaaataggccgtgggatattaagccgcaatggtcgaaacttggtgatccgaacgaaaaagatttggctggtcagagaatggtcaactgcacagtggtggaaggttcgctgacaatctcatttgtactgaaacacaagacaaaagcacaagaagaaatgcatcgaagtctacagccaagatattcccaagacgaatttatcacttttccgcatctacgtgaaattactggaactctgctcgtttttgagactgaaggattagtggatttgcgtaaaattttcccaaatcttcgtgtaattggaggccgttcgctgattcaacactatgcgctgataatttatcgaaatccggatttggagatcggtcttgacaagctttccgtaattcgaaatggtggtgtacggataatcgataatcgaaaactgtgctacacgaaaacgattgattggaaacatttgatcacttcttccatcaacgatgttgtcgttgataatgctgccgagtacgctgtcactgagactggattgatgtgcccacgtggagcttgcgaagaggataaaggcgaatcaaagtgtcattatttggaggaaaagaatcaggaacaaggtgtcgaaagagttcagagttgttggtcgaacaccacttgccaaaagtcttgtgcttatgatcgtcttcttccaacgaaagaaatcggaccgggatgtgatgcgaacggcgatcgatgtcacgatcaatgcgtgggcggttgtgagcgtgtgaatgatgcgacagcatgccacgcgtgcaagaatgtctatcacaagggaaagtgtatcgaaaagtgtgatgctcacctgtaccttctccttcaacgtcgttgtgtgacccgtgagcagtgtctgcagctgaatccggtgctctcgaacaaaacagtgcctatcaaggcgacggcaggcctttgctcggataaatgtcccgatggttatcaaatcaacccggatgatcatcgagaatgccgaaaatgcgttggcaagtgtgagattgtgtgcgagatcaatcacgtcattgatacgtttccgaaggcacaggcgatcaggctatgcaatattattgacggaaatctgacgatcgagattcgcggaaaacaggattcgggaatggcgtccgagttgaaggatatatttgcgaacattcacacgatcaccggctacctgttggtacgtcaatcgtcaccgtttatctcgttgaacatgttccggaatttacgacgtattgaggcaaagtcactgttcagaaatctatatgctatcacagtttttgaaaatccgaatttaaaaaagctattcgattcaacgacggatttgacgcttgatcgtggaactgtgtcaattgccaataacaagatgttatgcttcaagtatatcaagcagctaatgtcaaagttaaatataccactcgatccgatagatcaatcagaagggacaaatggtgagaaggcaatctgtgaggatatggcaatcaacgtgagcatcacagcggtcaacgcggactcggtcttctttagttggccctcattcaacattaccgatatagatcagcgaaagtttctcggctacgagctcttcttcaaagaagtcccacgaatcgatgagaacatgacgatcgaagaggatcgaagtgcgtgtgtcgattcgtggcagagtgtcttcaaacagtactacgagacgtcgaacggtgaaccgaccccggacatttttatggatattggaccgcgcgagcgaattcggccgaatacgctctacgcgtactatgtggcgacgcagatggtgttgcatgccggtgcgaagaacggtgtatcgaagattggttttgtgaggacgagctactatacgcctgatcctccgacgttggcactagcgcaagtcgattcggacgctattcatattacgtgggaagcgccgctccaaccgaacggagacctcacgcattacacaattatgtggcgtgagaatgaagtgagcccgtacgaggaagccgaaaagttttgtacagatgcaagcacccccgcaaatcgacaacacacgaaagatccgaaagagacgattgtagccgataagccagtcgatattccgtcatcacgtaccgtagctccgacacttttgactatgatgggtcacgaagatcagcagaaaacgtgcgctgcaacgcccggttgttgttcgtgttcggctatcgaagaatcatcggaacagaacaagaagaagcgaccggatccgatgtcggcgatcgaatcatctgcatttgagaataagctgttggatgaggttttaatgccgagagacacgatgcgagtgagacgatcaattgaagacgcgaatcgagtcagtgaagagttggaaaaagctgaaaatttgggaaaagctccaaaaactctcggtggaaagaagccgctgatccatatttcgaagaagaagccgtcgagcagcagcaccacatccacaccggctccaacgatcgcatcaatgtatgccttaacaaggaaaccgactacggtgccgggaacaaggattcggctctacgagatctacgaacctttacccggaagctgggcgattaatgtatcagctctggcattggataatagttatgtgatacgaaatttgaagcattacacactttatgcgatttctctatccgcgtgccaaaacatgacagtacccggagcatcttgctcaatatcccatcgtgcgg | |||
| Experiment | Laboratory | CF | |||
| Date | 22 Aug 2002 00:00:00 | ||||
| Strain | WBStrain00000001 | ||||
| Treatment | animals were shifted to bacteria expressing daf-2 dsRNA at different ages and their lifespans determined | ||||
| Delivered_by | Bacterial_feeding | ||||
| Inhibits | Predicted_gene | Y55D5A.5e | Inferred_automatically | RNAi_primary | |
| Y55D5A.5f | Inferred_automatically | RNAi_primary | |||
| Y55D5A.5c | Inferred_automatically | RNAi_primary | |||
| Y55D5A.5d | Inferred_automatically | RNAi_primary | |||
| Y55D5A.5a | Inferred_automatically | RNAi_primary | |||
| Gene | WBGene00000898 | Inferred_automatically | RNAi_primary | ||
| Transcript | Y55D5A.5e.1 | Inferred_automatically | RNAi_primary | ||
| Y55D5A.5b | Inferred_automatically | RNAi_primary | |||
| Y55D5A.5f.1 | Inferred_automatically | RNAi_primary | |||
| Y55D5A.5a.1 | Inferred_automatically | RNAi_primary | |||
| Y55D5A.5c.1 | Inferred_automatically | RNAi_primary | |||
| Y55D5A.5d.1 | Inferred_automatically | RNAi_primary | |||
| Species | Caenorhabditis elegans | ||||
| Reference | WBPaper00005488 | ||||
| Phenotype | WBPhenotype:0000061 | Remark | A similar lifespan extension was observed when animals were switched onto RNAi at different ages (egg, L1, L2, L3 ,L4 or young adults). Initiating daf-2 RNAi treatments later in adulthood, throughout the reproductive period, also extended lifespan, but the magnitude declined steadily, and became insignificant after about 6 days of adulthood. The authors interpret this to mean daf-2 is required during adulthood. To further this finding authors hatched animals on daf-2 RNAi and when they reached adulthood, they switched them to dcr-1 RNAi to turn off the RNAi process during adulthood and saw these animals did not have long lifespans. | ||
| Method | RNAi |
