WormBase Tree Display for Picture: WBPicture0000013087
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| WBPicture0000013087 | Description | Figure 4. Regulation of growth and metabolism by insulin signaling in C. elegans. Nutrients activate signaling by the DAF-2 insulin receptor to inhibit the FOXO-transcription factor DAF-16. This promotes growth and reproduction. Nutrient limitation down regulates signaling through the insulin receptor allowing activation of DAF-16. In an early larval stage, DAF-16 activity promotes dauer formation. In adults, DAF-16 reduces reproductive rate, enhances lifespan and causes fat accumulation. The C. elegans genome encodes numerous insulin-like molecules and those that signal nutritional availability are not known. Activated component of insulin signaling in different contexts of nutrient availability is shown in green. | |||
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| Name | FigJ.jpg | ||||
| Depict | WBProcess | WBbiopr:00000121 | |||
| Gene | WBGene00000898 | ||||
| WBGene00000912 | |||||
| Acknowledgment | Template | From: <Journal_URL> <Article_URL>. Copyright <Publication_year>. | |||
| Publication_year | 2007 | ||||
| Article_URL | DOI | id | 10.1895/wormbook.1.130.1 | ||
| Journal_URL | WormBook | ||||
| Publisher_URL | Caltech | ||||
| Reference | WBPaper00031290 |
