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| WBPicture0000013087 | Description | Figure 4. Regulation of growth and metabolism by insulin signaling in C. elegans. Nutrients activate signaling by the DAF-2 insulin receptor to inhibit the FOXO-transcription factor DAF-16. This promotes growth and reproduction. Nutrient limitation down regulates signaling through the insulin receptor allowing activation of DAF-16. In an early larval stage, DAF-16 activity promotes dauer formation. In adults, DAF-16 reduces reproductive rate, enhances lifespan and causes fat accumulation. The C. elegans genome encodes numerous insulin-like molecules and those that signal nutritional availability are not known. Activated component of insulin signaling in different contexts of nutrient availability is shown in green. |
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| Name | FigJ.jpg | |
| Depict (2) | ||
| Acknowledgment (5) | ||
| Reference | WBPaper00031290 |
