WormBase Tree Display for Disease_model_annotation: WBDOannot00001356
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| WBDOannot00001356 | Disease_term | DOID:9351 | |
|---|---|---|---|
| Disease_of_species | Homo sapiens | ||
| Modeled_by | Variation | WBVar00143949 | |
| Asserted_gene | WBGene00000898 | ||
| Association_type | is_implicated_in | ||
| Evidence_code | GO_code | IMP | |
| ECO_term | ECO:0007013 | ||
| Experimental_condition | Inducing_chemical | WBMol:00005569 | |
| Genetic_sex | hermaphrodite | ||
| Paper_evidence | WBPaper00064218 | ||
| Disease_model_description | Fractal scaling in animal behavioral activity, where similar temporal patterns appear repeatedly over a series of magnifcations among time scales, governs the complex behavior of various animal species and, in humans, can be altered by neurodegenerative diseases and aging. This study shows that the fractal kinetics of C. elegans behavior is regulated by insulin signaling; insulin signaling mutants showed increased frequency of the long-lasting active state compared to fed wild-type animals, such that the exponential-like decline at the longer time scale disappeared in the active state; this study suggests that comorbid behavioral defects in patients with diabetes may be attributed to altered fractal scaling of human behavior. | ||
| Curator_confirmed | WBPerson324 | ||
| Date_last_updated | 07 Nov 2022 00:00:00 |
