scpl-3 encodes two phosphatase isoforms that are members of the CTDSPL2 subfamily of protein phosphatases that has orthologs in most eukaryotes with the notable exception of Drosophilid insects and most fungi; by homology to human CTDSPL2, SCPL-3 is predicted to regulate transcription via dephosphorylation of residues in the RNA polymerase II C-terminal domain, and also dephosphorylation of residues in SMAD transriptional regulators that are part of transforming growth factor (TGF)-beta and bone morphogenetic protein (BMP) signaling pathways.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.