WormBase Tree Display for Gene: WBGene00007054
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| WBGene00007054 | SMap | S_parent | Sequence | B0379 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | scpl-1 | Person_evidence | WBPerson56 | |||||
| Sequence_name | B0379.4 | ||||||||
| Molecular_name | B0379.4a | ||||||||
| B0379.4a.1 | |||||||||
| CE34243 | |||||||||
| B0379.4b | |||||||||
| CE34244 | |||||||||
| B0379.4c | |||||||||
| CE41191 | |||||||||
| B0379.4b.1 | |||||||||
| B0379.4c.1 | |||||||||
| Other_name | tag-188 | Person_evidence | WBPerson201 | ||||||
| CELE_B0379.4 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | scpl-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 13:09:06 | WBPerson1845 | Event | Created | |||
| 2 | 05 Oct 2005 17:16:53 | WBPerson2970 | Event | Acquires_merge | WBGene00007157 | ||||
| Name_change | Sequence_name | B0379.4 | |||||||
| 3 | 02 Feb 2007 10:26:41 | WBPerson2970 | Name_change | CGC_name | scpl-1 | ||||
| Other_name | tag-188 | ||||||||
| Acquires_merge | WBGene00007157 | ||||||||
| WBGene00043085 | |||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | scpl | ||||||||
| Allele (181) | |||||||||
| Strain | WBStrain00031805 | ||||||||
| WBStrain00035918 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (45) | |||||||||
| Paralog | WBGene00021629 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00011897 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00018474 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | scpl-1 encodes, by alternative splicing, two protein isoforms of a putative class-C RNA polymerase II (RNAPII) carboxyl-terminal domain (CTD) phosphatase, orthologous to budding yeast PSR1 and PSR2 and human CTDSP1 (OMIM:605323), CTDSP2 (OMIM:608711, amplified in sarcoma), and CTDSPL (OMIM:608592, deleted in epithelial cancer), and paralogous to C. elegans SCPL-3 and human CTDSPL2; more distantly, SCPL-1 (and its paralog SCPL-3) are similar to SCPL-2, SCPL-4, and FCP-1; loss of scpl-1 activity via RNAi results in a slightly abnormal egg-laying response in the presence of serotonin; an scpl-1::gfp promoter fusion is expressed in pharyngeal, vulval, and body wall muscle; within body wall muscle, SCPL-1 localize to the M line and I band; SCPL-1 physically interacts with UNC-89 both in vitro and in vivo. | Paper_evidence | WBPaper00029277 | |||||
| WBPaper00029278 | |||||||||
| WBPaper00029279 | |||||||||
| WBPaper00029280 | |||||||||
| WBPaper00031595 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 16 Dec 2011 00:00:00 | ||||||||
| Automated_description | Enables several functions, including LIM domain binding activity; kinase binding activity; and protein-macromolecule adaptor activity. Involved in dephosphorylation and regulation of egg-laying behavior. Located in I band and M band. Expressed in body wall musculature; pharyngeal muscle cell; and vulval muscle. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Is an ortholog of human CTDSP1 (CTD small phosphatase 1) and CTDSPL (CTD small phosphatase like). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16890) | ||||
| Molecular_info | Corresponding_CDS | B0379.4a | |||||||
| B0379.4b | |||||||||
| B0379.4c | |||||||||
| Corresponding_CDS_history | B0379.4:wp77 | ||||||||
| B0379.4a:wp103 | |||||||||
| B0379.4b:wp103 | |||||||||
| Corresponding_transcript | B0379.4a.1 | ||||||||
| B0379.4b.1 | |||||||||
| B0379.4c.1 | |||||||||
| Other_sequence (38) | |||||||||
| Associated_feature (22) | |||||||||
| Transcription_factor | WBTranscriptionFactor000636 | ||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Chronogram589 | ||||||||
| Expr8052 | |||||||||
| Expr8053 | |||||||||
| Expr1015780 | |||||||||
| Expr1033029 | |||||||||
| Expr1143160 | |||||||||
| Expr2015647 | |||||||||
| Expr2033879 | |||||||||
| Drives_construct | WBCnstr00002821 | ||||||||
| WBCnstr00013080 | |||||||||
| Antibody | WBAntibody00001386 | ||||||||
| WBAntibody00001387 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (94) | |||||||||
| Interaction (39) | |||||||||
| Map_info | Map | I | Position | 4.63311 | Error | 0.019017 | |||
| Positive | Positive_clone | B0379 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5541 | |||||||
| 5251 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (11) | |||||||||
| Remark | tag-188 is parsed from CGC strain VC612 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
