cyb-3 encodes one of four C. elegans cyclin B family members that is most closely related to the B3-type cyclins; cyb-3 is required for a number of dynein-related mitotic processes and specifically for initiation of anaphase chromosome segregation; cyb-3 is also required for completion of meiosis II and proper pronuclear migration, centrosome maturation, and pronuclear condensation in the fertilized oocyte; cyb-3 is also essential for embryonic viability.
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including chromosome organization; regulation of cell cycle; and sexual reproduction. Acts upstream of or within nematode male tail tip morphogenesis. Located in cytoplasm and nucleus. Expressed in several structures, including EMS; Psub2; germ cell; germ line; and male gonad. Is an ortholog of human CCNB3 (cyclin B3).
[Monique Lorson] gene has homology to cyclin B3 genes in other organisms. 11/12/99
This gene has been defined and published both as cyb-2 and cyb-3. This old cyb-2 name should not be confused with the new cyb-2.1 and cyb-2.2 genes [020808 krb]
Sequence connection from [Xu H, Bennett KL]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.