WormBase Tree Display for Gene: WBGene00000865

WBGene00000865 SMap: S_parent: Sequence: ZC168
  Identity: Version: 1
    Name: CGC_name: cyb-1
      Sequence_name: ZC168.4
      Molecular_name: ZC168.4
        ZC168.4.1
        CE06570
        ZC168.4.2
      Other_name: CELE_ZC168.4 Accession_evidence: NDB BX284604
      Public_name: cyb-1
    DB_info: Database: AceView gene 4L501
        WormQTL gene WBGene00000865
        WormFlux gene WBGene00000865
        NDB locus_tag CELE_ZC168.4
        Panther gene CAEEL|WormBase=WBGene00000865|UniProtKB=Q10653
          family PTHR10177
        NCBI gene 177965
        RefSeq protein NM_069586.9
        SwissProt UniProtAcc Q10653
        TREEFAM TREEFAM_ID TF101001
        UniProt_GCRP UniProtAcc Q10653
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyb
    Allele (28)
    Legacy_information: [C.elegansII] NMK. 72% identity to sea urchin cyclin B. [KB]
    Strain: WBStrain00035505
      WBStrain00035506
      WBStrain00054975
      WBStrain00054710
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (45)
    Paralog (13)
    Structured_description: Concise_description: cyb-1 encodes a cyclin B homolog that appears to be required both for embryogenesis (via maternally encoded CYB-1) and for postembryonic development and fertility (via zygotically encoded CYB-1); removing maternal product in cyb-1(RNAi) embryos causes multiple nuclei, and affected embryos arrest development at an early embryonic stage. Paper_evidence: WBPaper00010444
            WBPaper00018070
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables cyclin-dependent protein serine/threonine kinase regulator activity and ubiquitin protein ligase binding activity. Involved in mitotic cell cycle; oocyte maturation; and positive regulation of protein phosphorylation. Located in cytoplasm and nucleus. Expressed in germ cell; male gonad; and oocyte. Human ortholog(s) of this gene implicated in several diseases, including in situ carcinoma; renal cell carcinoma; and reproductive organ cancer (multiple). Is an ortholog of human CCNB1 (cyclin B1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:2871 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
      DOID:4450 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
      DOID:8719 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
      DOID:2152 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
      DOID:10283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
      DOID:2526 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
      DOID:4362 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
  Molecular_info: Corresponding_CDS: ZC168.4
    Corresponding_transcript: ZC168.4.1
      ZC168.4.2
    Other_sequence (25)
    Associated_feature: WBsf646328
      WBsf655051
      WBsf229031
      WBsf229032
      WBsf229033
      WBsf229034
  Experimental_info: RNAi_result: WBRNAi00085858 Inferred_automatically: RNAi_primary
      WBRNAi00037964 Inferred_automatically: RNAi_primary
      WBRNAi00021586 Inferred_automatically: RNAi_primary
      WBRNAi00058758 Inferred_automatically: RNAi_primary
      WBRNAi00106163 Inferred_automatically: RNAi_primary
      WBRNAi00007847 Inferred_automatically: RNAi_primary
    Expr_pattern (14)
    Drives_construct: WBCnstr00001396
      WBCnstr00011275
      WBCnstr00037238
      WBCnstr00041759
    Construct_product: WBCnstr00000443
      WBCnstr00001396
      WBCnstr00007949
      WBCnstr00008139
      WBCnstr00011275
      WBCnstr00037238
      WBCnstr00041759
    Antibody: WBAntibody00001666
      WBAntibody00002044
      WBAntibody00002045
      WBAntibody00002768
    Microarray_results (24)
    Expression_cluster (225)
    Interaction (252)
  Map_info: Map: IV Position: 4.6818 Error: 0.002007
    Positive: Positive_clone: KB#1
        ZC168 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4245
        4322
    Pseudo_map_position
  Reference (32)
  Remark: Sequence connection from [Xu H, Bennett KL]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene