WormBase Tree Display for Gene: WBGene00000865

WBGene00000865 SMap: S_parent: Sequence: ZC168
  Identity: Version: 1
    Name: CGC_name: cyb-1
      Sequence_name: ZC168.4
      Molecular_name: ZC168.4
        ZC168.4.1
        CE06570
        ZC168.4.2
      Other_name: CELE_ZC168.4 Accession_evidence: NDB BX284604
      Public_name: cyb-1
    DB_info: Database: AceView gene 4L501
        WormQTL gene WBGene00000865
        WormFlux gene WBGene00000865
        NDB locus_tag CELE_ZC168.4
        Panther gene CAEEL|WormBase=WBGene00000865|UniProtKB=Q10653
          family PTHR10177
        NCBI gene 177965
        RefSeq protein NM_069586.9
        SwissProt UniProtAcc Q10653
        TREEFAM TREEFAM_ID TF101001
        UniProt_GCRP UniProtAcc Q10653
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyb
    Allele (28)
    Legacy_information: [C.elegansII] NMK. 72% identity to sea urchin cyclin B. [KB]
    Strain: WBStrain00035505
      WBStrain00035506
      WBStrain00054975
      WBStrain00054710
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (45)
    Paralog (13)
    Structured_description: Concise_description: cyb-1 encodes a cyclin B homolog that appears to be required both for embryogenesis (via maternally encoded CYB-1) and for postembryonic development and fertility (via zygotically encoded CYB-1); removing maternal product in cyb-1(RNAi) embryos causes multiple nuclei, and affected embryos arrest development at an early embryonic stage. Paper_evidence: WBPaper00010444
            WBPaper00018070
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables cyclin-dependent protein serine/threonine kinase regulator activity and ubiquitin protein ligase binding activity. Involved in mitotic cell cycle; oocyte maturation; and positive regulation of protein phosphorylation. Located in cytoplasm and nucleus. Expressed in germ cell; male gonad; and oocyte. Human ortholog(s) of this gene implicated in several diseases, including in situ carcinoma; renal cell carcinoma; and reproductive organ cancer (multiple). Is an ortholog of human CCNB1 (cyclin B1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:2871 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
      DOID:4450 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
      DOID:8719 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
      DOID:2152 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
      DOID:10283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
      DOID:2526 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
      DOID:4362 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
  Molecular_info: Corresponding_CDS: ZC168.4
    Corresponding_transcript: ZC168.4.1
      ZC168.4.2
    Other_sequence (25)
    Associated_feature: WBsf646328
      WBsf655051
      WBsf229031
      WBsf229032
      WBsf229033
      WBsf229034
  Experimental_info: RNAi_result: WBRNAi00085858 Inferred_automatically: RNAi_primary
      WBRNAi00037964 Inferred_automatically: RNAi_primary
      WBRNAi00021586 Inferred_automatically: RNAi_primary
      WBRNAi00058758 Inferred_automatically: RNAi_primary
      WBRNAi00106163 Inferred_automatically: RNAi_primary
      WBRNAi00007847 Inferred_automatically: RNAi_primary
    Expr_pattern (14)
    Drives_construct: WBCnstr00001396
      WBCnstr00011275
      WBCnstr00037238
      WBCnstr00041759
    Construct_product: WBCnstr00000443
      WBCnstr00001396
      WBCnstr00007949
      WBCnstr00008139
      WBCnstr00011275
      WBCnstr00037238
      WBCnstr00041759
    Antibody: WBAntibody00001666
      WBAntibody00002044
      WBAntibody00002045
      WBAntibody00002768
    Microarray_results (24)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032425:up_in_alg-1
      WBPaper00032425:up_in_lin-35
      WBPaper00032425:up_in_zfp-1
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037682:sma-2_upregulated
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00041071:spe-44_downregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:rising_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Spermatogenic
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00046012:tdp-1(ok803)_downregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_upregulated
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046509:htz-1(ok3099)_upregulated
      WBPaper00046509:lin-35(n745)_upregulated
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048762:FOG-3_associated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050193:cec-4(ok3124)_downregulated_L1
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00051558:fog-2(q71)_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:alovudine_72h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
      WBPaper00054191:H3.3(null)_L1_upregulated
      WBPaper00054792:FOG-3_interacting
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055648:sperm_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056619:CEPsh_enriched
      WBPaper00056826:SGP_biased
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058886:anp-1(ok608)_downregulated
      WBPaper00059027:neuron-synapses_enriched
      WBPaper00059174:MEG-3_interacting
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00059763:neuron_expressed
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060278:atp-2(RNAi)_upregulated
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061340:ABarpaaa_lineage
      WBPaper00061340:ADL_parent
      WBPaper00061340:AMso_parent
      WBPaper00061340:AVH_parent
      WBPaper00061340:Body_wall_muscle
      WBPaper00061340:Ciliated_amphid_neuron
      WBPaper00061340:Ciliated_non_amphid_neuron
      WBPaper00061340:Excretory_cell_parent
      WBPaper00061340:g2_parent
      WBPaper00061340:I2_grandparent
      WBPaper00061340:Neuroblast_ADF_AWB
      WBPaper00061340:Neuroblast_AFD_RMD
      WBPaper00061340:Neuroblast_AIZ_FLP
      WBPaper00061340:Neuroblast_ALA_RMED
      WBPaper00061340:Neuroblast_ASE_ASJ_AUA
      WBPaper00061340:Neuroblast_ASH_RIB
      WBPaper00061340:Neuroblast_ASJ_AUA
      WBPaper00061340:Neuroblast_AVG_RIR
      WBPaper00061340:Neuroblast_AWC_SAAVx
      WBPaper00061340:Neuroblast_BAG_SMDVx
      WBPaper00061340:Neuroblast_I6_M5
      WBPaper00061340:Neuroblast_IL1_IL2
      WBPaper00061340:Neuroblast_M2_M3
      WBPaper00061340:Neuroblast_URX_CEPDx
      WBPaper00061340:OLL_parent
      WBPaper00061340:OLQ_grandparent
      WBPaper00061340:OLQ_parent
      WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
      WBPaper00061340:Parents_of_U_F_B_DVA
      WBPaper00061340:Parent_of_AMsh_URB
      WBPaper00061340:Parent_of_hyp1V_and_ant_arc_V
      WBPaper00061340:Parent_of_hyp3_ILsoDx
      WBPaper00061340:Parent_of_K_Kprime
      WBPaper00061340:Parent_of_MI_pm1DR
      WBPaper00061340:Parent_of_tail_spike_and_hyp10
      WBPaper00061340:Pharyngeal_neuron
      WBPaper00061340:PLM_ALN_grandparent
      WBPaper00061340:PLM_ALN_great_grandparent
      WBPaper00061340:RIA_parent
      WBPaper00061340:RIC_parent
      WBPaper00061340:RIM_parent
      WBPaper00061527:cyy-1_3136-hcf-1_2478
      WBPaper00061527:pch-2-B0393.3
      WBPaper00061651:Sperm_enriched
      WBPaper00062056:lin-35(n745)_upregulated
      WBPaper00062056:lin-36(we36)_upregulated
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062590:Aging_upregulated_neuron
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064107:lin-35(n745)_upregulated
      WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064502:nhr-23(kry61);spe-44(fx110)_downregulated
      WBPaper00064505:tamoxifen_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065149:lin-52(n771)_upregulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065841:3_0
      WBPaper00065841:3_3
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_5_2
      cgc4489_group_10
      WBPaper00025032:cluster_32
      WBPaper00025032:cluster_143
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00027342:alpha-Synuclein(A53T)_upregulated
      WBPaper00027342:alpha-Synuclein(WT)_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00032165:differentially_expressed_with_age_medoid_1
      WBPaper00034757:down_by_oxidative_stress
      WBPaper00035227:heat_shock_regulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_B
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00038060:SUMO-1_upregulated
      WBPaper00039866:ClassComp_daf-19_upregulated
      WBPaper00039866:SAM_daf-19_upregulated
      WBPaper00040426:CYD-1_CDK-4_upregulated
      WBPaper00040426:CYE-1_CDK-2AF_upregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040963:TA300_down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo
      WBPaper00056330:mrps-5(RNAi)_downregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(53_min)
      [cgc5767]:expression_class_E_pi(53_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
      [cgc6390]:intrinsic
    Interaction (252)
  Map_info: Map: IV Position: 4.6818 Error: 0.002007
    Positive: Positive_clone: KB#1
        ZC168 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4245
        4322
    Pseudo_map_position
  Reference (32)
  Remark: Sequence connection from [Xu H, Bennett KL]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene