WormBase Tree Display for Gene: WBGene00000865

WBGene00000865 SMap: S_parent: Sequence: ZC168
  Identity: Version: 1
    Name: CGC_name: cyb-1
      Sequence_name: ZC168.4
      Molecular_name: ZC168.4
        ZC168.4.1
        CE06570
        ZC168.4.2
      Other_name: CELE_ZC168.4 Accession_evidence: NDB BX284604
      Public_name: cyb-1
    DB_info: Database: AceView gene 4L501
        WormQTL gene WBGene00000865
        WormFlux gene WBGene00000865
        NDB locus_tag CELE_ZC168.4
        Panther gene CAEEL|WormBase=WBGene00000865|UniProtKB=Q10653
          family PTHR10177
        NCBI gene 177965
        RefSeq protein NM_069586.9
        SwissProt UniProtAcc Q10653
        TREEFAM TREEFAM_ID TF101001
        UniProt_GCRP UniProtAcc Q10653
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyb
    Allele (28)
    Legacy_information: [C.elegansII] NMK. 72% identity to sea urchin cyclin B. [KB]
    Strain: WBStrain00035505
      WBStrain00035506
      WBStrain00054975
      WBStrain00054710
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (45)
    Paralog (13)
    Structured_description: Concise_description: cyb-1 encodes a cyclin B homolog that appears to be required both for embryogenesis (via maternally encoded CYB-1) and for postembryonic development and fertility (via zygotically encoded CYB-1); removing maternal product in cyb-1(RNAi) embryos causes multiple nuclei, and affected embryos arrest development at an early embryonic stage. Paper_evidence: WBPaper00010444
            WBPaper00018070
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables cyclin-dependent protein serine/threonine kinase regulator activity and ubiquitin protein ligase binding activity. Involved in mitotic cell cycle; oocyte maturation; and positive regulation of protein phosphorylation. Located in cytoplasm and nucleus. Expressed in germ cell; male gonad; and oocyte. Human ortholog(s) of this gene implicated in several diseases, including in situ carcinoma; renal cell carcinoma; and reproductive organ cancer (multiple). Is an ortholog of human CCNB1 (cyclin B1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:2871 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
      DOID:4450 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
      DOID:8719 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
      DOID:2152 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
      DOID:10283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
      DOID:2526 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
      DOID:4362 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1579)
  Molecular_info: Corresponding_CDS: ZC168.4
    Corresponding_transcript: ZC168.4.1
      ZC168.4.2
    Other_sequence (25)
    Associated_feature: WBsf646328
      WBsf655051
      WBsf229031
      WBsf229032
      WBsf229033
      WBsf229034
  Experimental_info: RNAi_result: WBRNAi00085858 Inferred_automatically: RNAi_primary
      WBRNAi00037964 Inferred_automatically: RNAi_primary
      WBRNAi00021586 Inferred_automatically: RNAi_primary
      WBRNAi00058758 Inferred_automatically: RNAi_primary
      WBRNAi00106163 Inferred_automatically: RNAi_primary
      WBRNAi00007847 Inferred_automatically: RNAi_primary
    Expr_pattern (14)
    Drives_construct: WBCnstr00001396
      WBCnstr00011275
      WBCnstr00037238
      WBCnstr00041759
    Construct_product: WBCnstr00000443
      WBCnstr00001396
      WBCnstr00007949
      WBCnstr00008139
      WBCnstr00011275
      WBCnstr00037238
      WBCnstr00041759
    Antibody: WBAntibody00001666
      WBAntibody00002044
      WBAntibody00002045
      WBAntibody00002768
    Microarray_results (24)
    Expression_cluster (225)
    Interaction: WBInteraction000004664
      WBInteraction000009599
      WBInteraction000009661
      WBInteraction000009683
      WBInteraction000028308
      WBInteraction000032789
      WBInteraction000032871
      WBInteraction000032909
      WBInteraction000032910
      WBInteraction000032911
      WBInteraction000032977
      WBInteraction000033062
      WBInteraction000033082
      WBInteraction000033144
      WBInteraction000033219
      WBInteraction000033220
      WBInteraction000033221
      WBInteraction000033222
      WBInteraction000033223
      WBInteraction000033260
      WBInteraction000033262
      WBInteraction000033263
      WBInteraction000033354
      WBInteraction000033414
      WBInteraction000033416
      WBInteraction000033526
      WBInteraction000033836
      WBInteraction000033861
      WBInteraction000033994
      WBInteraction000034542
      WBInteraction000034686
      WBInteraction000034805
      WBInteraction000035368
      WBInteraction000035369
      WBInteraction000035484
      WBInteraction000036391
      WBInteraction000036392
      WBInteraction000036767
      WBInteraction000037414
      WBInteraction000038874
      WBInteraction000039076
      WBInteraction000039176
      WBInteraction000039177
      WBInteraction000040053
      WBInteraction000040061
      WBInteraction000040189
      WBInteraction000042016
      WBInteraction000043145
      WBInteraction000043146
      WBInteraction000044210
      WBInteraction000044317
      WBInteraction000044385
      WBInteraction000046059
      WBInteraction000046084
      WBInteraction000046873
      WBInteraction000047396
      WBInteraction000047764
      WBInteraction000047957
      WBInteraction000049550
      WBInteraction000049623
      WBInteraction000103087
      WBInteraction000109766
      WBInteraction000112729
      WBInteraction000113454
      WBInteraction000117653
      WBInteraction000120267
      WBInteraction000120355
      WBInteraction000120598
      WBInteraction000120682
      WBInteraction000121145
      WBInteraction000121481
      WBInteraction000125513
      WBInteraction000126660
      WBInteraction000127011
      WBInteraction000127014
      WBInteraction000127681
      WBInteraction000127688
      WBInteraction000127697
      WBInteraction000127940
      WBInteraction000128242
      WBInteraction000128251
      WBInteraction000128563
      WBInteraction000128568
      WBInteraction000128575
      WBInteraction000128646
      WBInteraction000131739
      WBInteraction000131795
      WBInteraction000131817
      WBInteraction000133616
      WBInteraction000135466
      WBInteraction000145400
      WBInteraction000145536
      WBInteraction000145994
      WBInteraction000145997
      WBInteraction000148288
      WBInteraction000150972
      WBInteraction000153568
      WBInteraction000153571
      WBInteraction000153572
      WBInteraction000153573
      WBInteraction000153579
      WBInteraction000154139
      WBInteraction000154169
      WBInteraction000154275
      WBInteraction000154279
      WBInteraction000154283
      WBInteraction000154286
      WBInteraction000154290
      WBInteraction000154294
      WBInteraction000154298
      WBInteraction000154301
      WBInteraction000154305
      WBInteraction000154308
      WBInteraction000154310
      WBInteraction000154313
      WBInteraction000154317
      WBInteraction000154957
      WBInteraction000154960
      WBInteraction000154964
      WBInteraction000154968
      WBInteraction000154972
      WBInteraction000154976
      WBInteraction000154980
      WBInteraction000154983
      WBInteraction000154986
      WBInteraction000154990
      WBInteraction000155105
      WBInteraction000155109
      WBInteraction000155113
      WBInteraction000155117
      WBInteraction000155121
      WBInteraction000155127
      WBInteraction000155131
      WBInteraction000155791
      WBInteraction000155804
      WBInteraction000156105
      WBInteraction000156239
      WBInteraction000158030
      WBInteraction000158543
      WBInteraction000161026
      WBInteraction000161042
      WBInteraction000161045
      WBInteraction000161802
      WBInteraction000161863
      WBInteraction000162441
      WBInteraction000162679
      WBInteraction000164250
      WBInteraction000164433
      WBInteraction000165271
      WBInteraction000167482
      WBInteraction000167881
      WBInteraction000172964
      WBInteraction000173027
      WBInteraction000174071
      WBInteraction000175770
      WBInteraction000177520
      WBInteraction000189571
      WBInteraction000190033
      WBInteraction000190960
      WBInteraction000191847
      WBInteraction000192145
      WBInteraction000198860
      WBInteraction000206331
      WBInteraction000208724
      WBInteraction000211312
      WBInteraction000213480
      WBInteraction000218061
      WBInteraction000219461
      WBInteraction000224615
      WBInteraction000235493
      WBInteraction000236654
      WBInteraction000237446
      WBInteraction000258728
      WBInteraction000261130
      WBInteraction000261213
      WBInteraction000262016
      WBInteraction000271054
      WBInteraction000275311
      WBInteraction000296436
      WBInteraction000301318
      WBInteraction000301552
      WBInteraction000303915
      WBInteraction000308516
      WBInteraction000311166
      WBInteraction000312584
      WBInteraction000313721
      WBInteraction000316144
      WBInteraction000316405
      WBInteraction000318868
      WBInteraction000319157
      WBInteraction000320266
      WBInteraction000322948
      WBInteraction000325034
      WBInteraction000328228
      WBInteraction000328833
      WBInteraction000329569
      WBInteraction000330440
      WBInteraction000335928
      WBInteraction000337843
      WBInteraction000340001
      WBInteraction000342276
      WBInteraction000342357
      WBInteraction000342536
      WBInteraction000347001
      WBInteraction000347152
      WBInteraction000349647
      WBInteraction000349652
      WBInteraction000350813
      WBInteraction000353822
      WBInteraction000354940
      WBInteraction000356806
      WBInteraction000358098
      WBInteraction000364535
      WBInteraction000370870
      WBInteraction000380453
      WBInteraction000387047
      WBInteraction000392586
      WBInteraction000393242
      WBInteraction000404724
      WBInteraction000412149
      WBInteraction000414263
      WBInteraction000415315
      WBInteraction000419408
      WBInteraction000422591
      WBInteraction000425489
      WBInteraction000430357
      WBInteraction000432914
      WBInteraction000436946
      WBInteraction000438180
      WBInteraction000447834
      WBInteraction000456346
      WBInteraction000456709
      WBInteraction000460148
      WBInteraction000463995
      WBInteraction000465651
      WBInteraction000468025
      WBInteraction000468605
      WBInteraction000504541
      WBInteraction000520039
      WBInteraction000522179
      WBInteraction000522197
      WBInteraction000523064
      WBInteraction000523065
      WBInteraction000523806
      WBInteraction000540004
      WBInteraction000540758
      WBInteraction000544781
      WBInteraction000544782
      WBInteraction000554696
      WBInteraction000556769
      WBInteraction000569073
      WBInteraction000579694
  Map_info: Map: IV Position: 4.6818 Error: 0.002007
    Positive: Positive_clone: KB#1
        ZC168 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4245
        4322
    Pseudo_map_position
  Reference (32)
  Remark: Sequence connection from [Xu H, Bennett KL]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene