WormBase Tree Display for Gene: WBGene00014215

WBGene00014215 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 2
    Name: CGC_name: obr-3 Person_evidence: WBPerson1105
      Sequence_name: ZK1086.1
      Molecular_name (6)
      Other_name: CELE_ZK1086.1 Accession_evidence: NDB BX284606
      Public_name: obr-3
    DB_info: Database: AceView gene XO418
        WormQTL gene WBGene00014215
        WormFlux gene WBGene00014215
        NDB locus_tag CELE_ZK1086.1
        Panther gene CAEEL|WormBase=WBGene00014215|UniProtKB=Q8MPR9
          family PTHR10972
        NCBI gene 181495
        RefSeq protein NM_001392877.1
            NM_171794.7
        TREEFAM TREEFAM_ID TF312807
        TrEMBL UniProtAcc Q8MPR9
            G5EC19
        UniProt_GCRP UniProtAcc Q8MPR9
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:55 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 02 Jul 2004 16:55:45 WBPerson1971 Name_change: CGC_name: obr-3
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: obr
    Allele (217)
    RNASeq_FPKM (74)
    GO_annotation (12)
    Ortholog (37)
    Paralog: WBGene00008832 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012930 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00016331 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: obr-3 encodes two isoforms of a protein with an N-terminal pleckstrin domain and a C-terminal oxysterol-binding domain; OBR-3 has orthologs in Drosophila (CG5077) and humans (OSBPL8; OMIM:606736); OBR-3 binds the BMP receptor-associated molecule (BRAM) proteins BRA-1 and BRA-2; obr-3 is expressed in pharyngeal muscle, hypodermis, and several neurons; obr-3 is required for normally large body size, and the small body phenotype of obr-3(RNAi) animals is consistent with OBR-3 participating in TGF-beta signalling. Paper_evidence: WBPaper00004823
            WBPaper00012885
            WBPaper00012937
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 08 Nov 2010 00:00:00
      Automated_description: Predicted to enable cholesterol binding activity and sterol transporter activity. Involved in regulation of growth and transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol; intracellular membrane-bounded organelle; and membrane. Expressed in hypodermis; neurons; and pharyngeal muscle cell. Is an ortholog of human OSBPL5 (oxysterol binding protein like 5) and OSBPL8 (oxysterol binding protein like 8). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: ZK1086.1a
      ZK1086.1b
    Corresponding_CDS_history: ZK1086.1:wp83
    Corresponding_transcript: ZK1086.1a.1
      ZK1086.1b.1
    Other_sequence (19)
    Associated_feature (15)
  Experimental_info: RNAi_result: WBRNAi00021799 Inferred_automatically: RNAi_primary
      WBRNAi00059099 Inferred_automatically: RNAi_primary
      WBRNAi00038141 Inferred_automatically: RNAi_primary
      WBRNAi00091933 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1629
      Expr1026177
      Expr1036370
      Expr1162528
      Expr2014593
      Expr2032826
    Drives_construct: WBCnstr00010358
      WBCnstr00029219
    Construct_product: WBCnstr00010358
      WBCnstr00029219
    Microarray_results (27)
    Expression_cluster: WBPaper00032425:up_in_zfp-1
      WBPaper00032976:dosage_compensated_genes
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:excretory-cell_larva_enriched
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Oogenic
      WBPaper00046499:AMPK_regulated
      WBPaper00046805:csr-1(RNAi)_downregulated_Set1
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049018:swsn-2.2(RNAi)_downregulated
      WBPaper00049498:npr-1(ur89)_regulated_7
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050686:glp-1(e2141)_upregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00053020:sta-1(ok587)_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056034:pals-25(jy9)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056167:ifo-1(kc2)_downregulated
      WBPaper00056218:daf-16(mu86)_upregulated_Day7
      WBPaper00056284:ints-11(RNAi)_downregulated
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058942:henn-1(pk2295)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059763:neuron_expressed
      WBPaper00059987:Wounding_upregulated
      WBPaper00060084:cco-1(RNAi)_upregulated_N2
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061340:PVP
      WBPaper00061527:kin-29_2839-unc-9_3883
      WBPaper00061527:ldb-1_2877-scd-1_3086
      WBPaper00061527:tub-2_4713-daf-2_5288
      WBPaper00061651:AVF_enriched
      WBPaper00061651:I3_enriched
      WBPaper00061651:M4_enriched
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064532:pals-22(jy3)_upregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064637:cox-5B(RNAi)_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00027111:rrf-3(pk1426)_downregulated
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00030985:Erwinia_carotovora_downregulated
      WBPaper00031003:hlh_1_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00035905:FBF-1_Associated
      WBPaper00037695:WC_5-day
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045263:ProLongevity-mtROS_upregulated
      WBPaper00045960:L1-L4-lethargus_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
    Interaction: WBInteraction000111256
      WBInteraction000222018
      WBInteraction000385708
      WBInteraction000403215
      WBInteraction000446791
      WBInteraction000449697
      WBInteraction000466421
      WBInteraction000541283
      WBInteraction000548958
  Map_info: Map: X Position: 14.9473 Error: 0.029025
    Positive: Positive_clone: ZK1086 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4859
        4827
        4961
    Pseudo_map_position
  Reference: WBPaper00010145
    WBPaper00030935
    WBPaper00031972
    WBPaper00038491
    WBPaper00053705
    WBPaper00055090
    WBPaper00060493
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene