WormBase Tree Display for Gene: WBGene00001395

WBGene00001395 SMap: S_parent: Sequence: CHROMOSOME_IV
  Identity: Version: 1
    Name: CGC_name: fat-3
      Sequence_name: W08D2.4
      Molecular_name (12)
      Other_name: CELE_W08D2.4 Accession_evidence: NDB BX284604
      Public_name: fat-3
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: fat
    Allele (56)
    Legacy_information: [Barnes TM] fat for FATty acid metabolism. Encodes predicted enzyme for beta-oxidation of fatty acids. Predicted gene C17G10.8
    Strain: WBStrain00036068
      WBStrain00004012
    RNASeq_FPKM (74)
    GO_annotation (30)
    Ortholog (41)
    Paralog: WBGene00001396 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: fat-3 encodes a delta-6 fatty acid desaturase ('linoleoyl-CoA desaturase') containing an N-terminal cytochrome b5 domain that is orthologous to the vertebrate fatty acid desaturases (FADS); FAT-3 expressed in yeast uses linoleic and alpha-linolenic acid as substrates; FAT-3 is absolutely required in vivo for synthesis of delta-6 fatty acids, and also required for fully normal synthesis of C20 fatty acids; FAT-3 is required for a normally fast growth rate and movement speed, and for normal defecation rhythms and fertility; fat-3 is also required for regulation of basal innate immunity. Paper_evidence: WBPaper00003032
            WBPaper00003387
            WBPaper00003999
            WBPaper00005233
            WBPaper00005728
            WBPaper00013538
            WBPaper00013550
            WBPaper00013584
            WBPaper00032370
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 16 May 2014 00:00:00
      Automated_description: Enables stearoyl-CoA 9-desaturase activity. Involved in several processes, including egg-laying behavior; signal release; and system process. Predicted to be located in membrane. Expressed in body wall musculature; head neurons; intestine; pharynx; and tail neurons. Used to study alcohol use disorder and lipid metabolism disorder. Is an ortholog of human FADS2 (fatty acid desaturase 2) and FADS3 (fatty acid desaturase 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1574 Homo sapiens Paper_evidence: WBPaper00045655
          Curator_confirmed: WBPerson324
          Date_last_updated: 05 Jun 2019 00:00:00
      DOID:3146 Homo sapiens Paper_evidence: WBPaper00060352
          Curator_confirmed: WBPerson324
          Date_last_updated: 21 Jan 2021 00:00:00
    Potential_model: DOID:12930 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3575)
  Models_disease_asserted: WBDOannot00000699
    WBDOannot00000845
  Molecular_info: Corresponding_CDS: W08D2.4a
      W08D2.4b
      W08D2.4c
      W08D2.4d
    Corresponding_transcript (4)
    Other_sequence (97)
    Associated_feature: WBsf646256
      WBsf660531
      WBsf660532
      WBsf978983
      WBsf228878
  Experimental_info: RNAi_result (16)
    Expr_pattern: Expr2386
      Expr1028132
      Expr1030835
      Expr1158509
      Expr2011436
      Expr2029674
    Drives_construct: WBCnstr00010806
      WBCnstr00019118
      WBCnstr00036974
    Construct_product: WBCnstr00010806
      WBCnstr00036974
    Microarray_results (24)
    Expression_cluster: WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_embryo_enriched
      WBPaper00037950:coelomocytes_embryo_SelectivelyEnriched
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:hypodermis_larva_SelectivelyEnriched
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_embryo_SelectivelyEnriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_larva_enriched
      WBPaper00037950:PVD-OLL-neurons_larva_SelectivelyEnriched
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
      WBPaper00044030:nhr-8(hd117)_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045314:S.aureus-induced_N2
      WBPaper00045521:Gender_Neutral
      WBPaper00045774:clk-1_upregulated
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_downregulated_protein
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048926:miaserin_upregulated_adult-day10
      WBPaper00048952:glucose_induced
      WBPaper00048988:daf-16(mu86)_downregulated_neuron
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00050332:skr-1(RNAi)-skr-2(RNAi)_downregulated
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:spc-1(cas971)_downregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057083:daf-2(e1370)rsks-1(ok1255)_post-transcriptional_downregulated
      WBPaper00058665:amino-functionized-graphene-oxide_downregulated_mRNA
      WBPaper00058665:graphene-oxide_downregulated_mRNA
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058711:paraquat_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059253:stearic-acid_upregulated
      WBPaper00059253:sucrose_stearic-acid_upregulated
      WBPaper00059253:sucrose_upregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059754:C.neoformans_H99_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060683:hlh-11(overexpression)_downregulated
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-extract_4h_regulated
      WBPaper00060886:spr-5(by101)_upregulated
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640)
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:mc3
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:R10H10.3-T21H3.1
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062440:crh-1(syb385)_downregulated
      WBPaper00062456:doxycycline_upregulated_CB4856_protein
      WBPaper00062520:qui-1(db104)_downregulated
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064225:heat-shock_downregulated_protein
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00064871:hypoxia_downregulated_F3
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066005:RAGA-1_degradation_somatic_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066085:sin-3(syb2172)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4386_cluster_1_1
      cgc4489_group_9
      WBPaper00005124:progesterone_10-7M_regulated
      WBPaper00025032:cluster_2
      WBPaper00025099:MA_specific
      WBPaper00025099:NI_specific
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00031003:hlh_1_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00031662:spaceflight_upregulated
      WBPaper00032062:age_regulated_genes
      WBPaper00032165:differentially_expressed_with_age_medoid_4
      WBPaper00032948:StarveUp3
      WBPaper00034739:N2moreDR1350
      WBPaper00036286:Pattern_I
      WBPaper00038060:SUMO-1_downregulated
      WBPaper00039866:ClassComp_daf-19_upregulated
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040963:Q100_up
      WBPaper00040963:Q200_up
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041174:environmental
      WBPaper00041174:environmental_prime
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042178:hlh-29(tm284)_upregulated
      WBPaper00042274:tbx-2(bx59)_upregulated
      WBPaper00044091:Bpseudomallei_repressed_8h
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045263:ProLongevity-mtROS_downregulated
      WBPaper00045865:biofilm_upregulated_A
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00046548:dafachronic-acid_upregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00050538:Fasting_upregulated
      WBPaper00050538:Fasting_upregulated_cholesterol-dependent
      WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo
      WBPaper00053688:E.faecalis_upregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(66_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5976]:class_1
    Interaction (172)
    Anatomy_function: WBbtf0243
      WBbtf0244
      WBbtf0245
      WBbtf0246
      WBbtf0247
      WBbtf0248
      WBbtf0249
    WBProcess: WBbiopr:00000002
      WBbiopr:00000039
      WBbiopr:00000121
  Map_info: Map: IV Position: 4.42122 Error: 0.000463
    Positive: Positive_clone: W08D2 Person_evidence: WBPerson681
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4299
        4300
    Pseudo_map_position
  Reference (82)
  Remark: C17G10.8 link removed by agreement [sdm 0107]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene