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WormBase Tree Display for Gene: WBGene00003515

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Name Class

WBGene00003515SMapS_parentSequenceK12F2
IdentityVersion1
NameCGC_namemyo-3Person_evidenceWBPerson261
Sequence_nameK12F2.1
Molecular_name (3)
Other_namesup-3
CELE_K12F2.1Accession_evidenceNDBBX284605
Public_namemyo-3
DB_infoDatabaseAceViewgene5M708
WormQTLgeneWBGene00003515
WormFluxgeneWBGene00003515
NDBlocus_tagCELE_K12F2.1
PanthergeneCAEEL|WormBase=WBGene00003515|UniProtKB=P12844
familyPTHR45615
NCBIgene179676
RefSeqproteinNM_073664.7
SwissProtUniProtAccP12844
UniProt_GCRPUniProtAccP12844
OMIMgene160710
160720
160740
160741
160760
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:32WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classmyo
Allele (121)
Legacy_informationStructural gene for minor body-wall myosin heavy chain. Mutation st378 is probable null for myo-3 : late embryonic lethal very abnormal muscle ultrastructure. See also sup-3.
e1407sd : partial suppressor of certain mutations of muscle genes unc-15 unc-54 unc-87 e.g. unc-15(e73) unc-54(e1315); no phenotype alone; may be associated with alteration of minor body wall myosin gene myo-3 V and causes increased levels of myo-3 product. Deficiency eDf1 has sup-3 activity. ES3 in presence of e73 ME3. NA > 10 (e1390 etc.). Also super-suppressor alleles (unstable) and antisuppressor alleles derived from e1407 etc.
See also e1390, e1405, e1407, m139, m141, m148, m157, m207, s196, st90, st92
[Williams BD] Pat (paralysed arrest at two-fold), severe paralysis.
[C.elegansII] st386 : severe Pat (paralysed embryonic arrest at two-fold stage); very abnormal muscle ultrastructure, no MYO-3 staining.OA2 (Pat): st563, st565. Also duplication alleles: e1407sd(pka sup-3, partial suppressor of certain mutations of muscle genes unc-15, unc-54, unc-87), e1390, etc.; Also super-suppressor alleles (unstable). All probably tandem duplications or further amplifications of myo-3. [Dibb et al. 1989; Maruyama et al. 1989; Williams and Waterston 1989]
Strain (34)
RNASeq_FPKM (74)
GO_annotation (31)
Ortholog (80)
ParalogWBGene00002348Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003514Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006789Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00019064Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00009730Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00012437Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003776Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00003777Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00002035Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00002036Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00002037Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00002038Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00002039Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00002040Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00002041Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00004969Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00006754Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00015356Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00015968Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00018317Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00018377Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionmyo-3 encodes MHC A, the minor isoform of MHC (myosin heavy chain) that is essential for thick filament formation, and for viability, movement, and embryonic elongation; expressed in body muscle, the somatic sheath cell covering the hermaphrodite gonad, and also expressed in enteric muscle, vulval muscles of the hermaphrodite and the diagonal muscles of the male tail.Paper_evidence (11)
Curator_confirmedWBPerson48
Date_last_updated21 Jan 2005 00:00:00
Automated_descriptionEnables cytoskeletal motor activity. Involved in locomotory behavior and positive regulation of ovulation. Located in A band and striated muscle myosin thick filament. Expressed in body wall musculature; enteric muscle; gonad; vulval muscle; and in male. Human ortholog(s) of this gene implicated in several diseases, including congenital heart disease (multiple); distal myopathy 1; and intrinsic cardiomyopathy (multiple). Is an ortholog of several human genes including MYH1 (myosin heavy chain 1); MYH2 (myosin heavy chain 2); and MYH3 (myosin heavy chain 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (30)
Molecular_infoCorresponding_CDSK12F2.1
Corresponding_CDS_historyK12F2.1:wp106
Corresponding_transcriptK12F2.1.1
Other_sequence (194)
Associated_feature (11)
Experimental_infoRNAi_result (11)
Expr_pattern (14)
Drives_construct (391)
Construct_productWBCnstr00009392
WBCnstr00019120
WBCnstr00021706
WBCnstr00036079
AntibodyWBAntibody00000014
WBAntibody00000019
WBAntibody00000391
WBAntibody00001784
Microarray_results (18)
Expression_clusterWBPaper00029047:atx-3_upregulated
WBPaper00029359_1217
WBPaper00029359_1280
WBPaper00029359_1353
WBPaper00029359_1444
WBPaper00029359_1504
WBPaper00029359_1548
WBPaper00029359_1604
WBPaper00031040:TGF-beta_adult_upregulated
WBPaper00032009:nhr-40(ok667)_downregulated
WBPaper00032528:L3_enriched
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00035073:mitochondria_protein
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037047:insoluble_protein
WBPaper00037950:bodywall-muscle_CoreEnriched
WBPaper00037950:bodywall-muscle_embryo_enriched
WBPaper00037950:bodywall-muscle_embryo_SelectivelyEnriched
WBPaper00037950:bodywall-muscle_L1-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:bodywall-muscle_larva_enriched
WBPaper00037950:bodywall-muscle_larva_SelectivelyEnriched
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038168:lin-15B(n744)_upregulated
WBPaper00038289:oocyte_protein
WBPaper00038357:atx-3_regulated_heat-shock
WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
WBPaper00042561:smgl-1(RNAi)_upregulated
WBPaper00043951:insoluble_protein_day16_N2
WBPaper00044128:DietaryRestriction_upregulated
WBPaper00044246:pgrn-1_ced-1_downregulated
WBPaper00044260:1-methylnicotinamide_upregulated
WBPaper00044260:nicotinc-acid_upregulated
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044736:flat_dev_expression
WBPaper00044746:aging_downregulated_Day5
WBPaper00044746:aging_downregulated_Day10
WBPaper00044746:aging_downregulated_HeatShock
WBPaper00045314:S.aureus-induced_N2
WBPaper00045417:128Q-huntingtin_upreglated
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_upregulated
WBPaper00045774:clk-1_upregulated
WBPaper00046121:mesoderm_unique
WBPaper00046446:slow-synthesized_YoungAdult
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
WBPaper00047131:daf-2(e1370)_upregulated_N2-background
WBPaper00048910:Apoptosis-induced_mRNA-interacting_protein
WBPaper00048910:mRNA-interacting_protein
WBPaper00048971:daf-16(mgDf50)_downregulated_L1
WBPaper00048988:neuron_expressed
WBPaper00049217:TCER-1_downregulated
WBPaper00049498:npr-1(ur89)_regulated_3
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
WBPaper00049920:Glucose-Diet_upregulated_N2
WBPaper00049942:HeatShock_upregulated_hsf-1(+)
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00049954:BPS_downregulated
WBPaper00050053:muscle_enriched_Day4
WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
WBPaper00050225:flp-6(RNAi)_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050686:glp-1(e2141)_upregulated
WBPaper00050698:DEP-1_interacting
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:seam_expressed
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:body-wall-muscle_nucleus_expressed
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051461:pig-1(gm344)_downregulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053295:lin-22(icb38)_upregulated
WBPaper00053302:alovudine_72h_regulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:stavudine_72h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053318:Aging_downregulated_mRNA_N2
WBPaper00053318:mir-71(n4115)_downregulated_mRNA
WBPaper00053321:mes-4(RNAi)_downregulated_fed-L1_Truseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_fed-L1_Truseq
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053388:dauer_regulated_Cluster1
WBPaper00053599:oocyte_vs_mitosis_downregulated
WBPaper00053657:N2_M.humicola-infection_24hr
WBPaper00053771:up_at_dpy-7(e88)
WBPaper00054493:hpl-2(tm1489)_upregulated
WBPaper00055049:S.gordonii_upregulated
WBPaper00055103:thoc-5(wy822)_downregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055354:eat-2(ad1116)_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055386:daf-2(e1370)_upregulated
WBPaper00055482:Tunicamycin_downregulated
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00055897:heat-shock_upregulated
WBPaper00055969:electromagnetic-field_downregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056139:soil-microbiota_upregulated
WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
WBPaper00056284:ints-1(RNAi)_downregulated
WBPaper00056443:DietaryRestriction_downregulated
WBPaper00056809:smn-1(ok355)_downregulated
WBPaper00056826:hmc_biased
WBPaper00056868:P.aeruginosa_upregulated_smallRNA
WBPaper00056900:ERH-2_interacting
WBPaper00056900:PID-3_interacting
WBPaper00056900:TOFU-6_interacting
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057006:DietaryRestriction_upregulated
WBPaper00057154:HeatShock_upregulated_mRNA
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_upregulated_protein
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058942:henn-1(pk2295)_upregulated
WBPaper00058958:100mGy-irradiation-72h_upregulated
WBPaper00059117:B.subtilis_upregulated
WBPaper00059328:mrps-5(RNAi)_downregulated_protein
WBPaper00059421:daf-3(mgDf90)_downregulated
WBPaper00059605:MUT-16_interacting
WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059728:5ug_cholesterol_upregulated
WBPaper00059728:20ug_cholesterol_upregulated
WBPaper00059739:hira-1(gk835598)_downregulated_L4
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00059839:S.maltophilia_regulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060273:isp-1(qm150)_upregulated
WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
WBPaper00060661:sensory-neuron_enriched
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00061203:let-418(n3536)_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061221:H4K8ac_interacting
WBPaper00061340:BWM_anterior
WBPaper00061340:BWM_far_posterior
WBPaper00061340:mu_sph
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061377:MYRF-1_interacting
WBPaper00061377:MYRF-2_interacting
WBPaper00061377:PAN-1_interacting
WBPaper00061424:Diet_MYb120_upregulated
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061479:prg-1(tm872)_upregulated
WBPaper00061527:myo-3-Y71G12B.11_22540
WBPaper00061818:AFD_enriched_protein
WBPaper00061995:mter-4(syb3662syb3403)_downregulated
WBPaper00062143:PQN-59_interacting
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062498:PPM-1.D_interacting
WBPaper00062554:MAGU-2_interacting
WBPaper00062590:Aging_downregulated_neuron
WBPaper00064055:trl-1(cas1077)_upregulated_non-starved
WBPaper00064055:trl-1(cas1077)_upregulated_starved
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
WBPaper00064156:lbp-3(overexpress)_upregulated
WBPaper00064201:SNA-1_interacting
WBPaper00064201:SNA-3_interacting
WBPaper00064257:UNG-1_interacting
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064624:iHg-induced_aggregome
WBPaper00064716:paraquat_downregulated
WBPaper00064727:daf-2(e1370)_upregulated
WBPaper00064789:Day9_vs_Day1_upregulated_neuron
WBPaper00064871:hypoxia_downregulated_F3
WBPaper00064933:E.coli-binding_secret_protein
WBPaper00065032:PAO1_vs_Delt.Pf4-infection_downregulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065158:AFD_enriched
WBPaper00065258:anchor-cell_depleted
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065373:sek-1(km4)_upregulated_cisplatin
WBPaper00065373:sek-1(km4)_upregulated_Ref
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065734:unc-25(e156)_upregulated
WBPaper00065746:eat-2(ad1113)_downregulated
WBPaper00065749:Heat-Shock_upregulated_N2
WBPaper00065835:Day5_vs_Day1_downregulated
WBPaper00065835:Day11_vs_Day1_downregulated
WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
WBPaper00065841:1_1
WBPaper00065841:4_0
WBPaper00065841:4_1
WBPaper00065841:7_0
WBPaper00065841:7_1
WBPaper00065841:7_2
WBPaper00065841:7_3
WBPaper00065841:7_4
WBPaper00065841:38_1
WBPaper00065841:38_3
WBPaper00065841:102_0
WBPaper00065841:143_0
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066110:tetraploid_vs_diploid_upregulated
WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
cgc4386_cluster_5_6
cgc4489_group_8
WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00031003:0hr_muscle_enriched
WBPaper00031003:24hr_muscle_enriched
WBPaper00031003:hlh_1_enriched
WBPaper00031003:total_muscle_enriched
WBPaper00031252:AIN-1_IP_enriched
WBPaper00031252:AIN-2_IP_enriched
WBPaper00031532:Larva_Pan_Neuronal_Depleted
WBPaper00032165:differentially_expressed_with_age_medoid_3
WBPaper00032948:StarveUp2
WBPaper00035084:L1_enriched_AIN-2_IP
WBPaper00035084:L2_enriched_AIN-2_IP
WBPaper00035084:L3_enriched_AIN-2_IP
WBPaper00035084:L4_enriched_AIN-2_IP
WBPaper00035479:daf-16(RNAi)_upregulated
WBPaper00035560:ahr-1_downregulated
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00035873:osm-8_regulated
WBPaper00036286:Pattern_C
WBPaper00037113:CPF_16C_up-regulated
WBPaper00038304:octr-1_regulated
WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
WBPaper00040210:Diazinon_24C_regulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040821:Au-NP_regulated
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040985:AIN-2_asynchronous_muscle
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041906:I-3690_vs_OP50_3d
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00041960:N2_fasting_upregulated_anytime
WBPaper00042331:a-SWCNTs_downregulated
WBPaper00045673:colistin_upregulated
WBPaper00048989:N2_allantoin_downregulated
[cgc6390]:Cluster_C
Interaction (183)
WBProcessWBbiopr:00000006
WBbiopr:00000040
Map_infoMapVPosition3.84005Error0.021073
Well_ordered
PositivePositive_cloneK12F2Inferred_automaticallyFrom sequence, transcript, pseudogene data
SG25/35
Mapping_data2_point141
315
3133
3134
Multi_point148
782
1176
1177
1178
2809
2817
5284
Pos_neg_data300
3135
854
866
Reference (284)
RemarkData extracted from Williams & Waterston 1994
yk1d8.5,yk1d8.3, removed from sequence list sdm 11/00
MethodGene