WormBase Tree Display for Gene: WBGene00003776
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| WBGene00003776 | SMap | S_parent | Sequence | F52B10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | nmy-1 | |||||||
| Sequence_name | F52B10.1 | ||||||||
| Molecular_name | F52B10.1a | ||||||||
| F52B10.1a.1 | |||||||||
| CE31177 | |||||||||
| F52B10.1b | |||||||||
| CE04618 | |||||||||
| F52B10.1b.1 | |||||||||
| Other_name | CELE_F52B10.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | nmy-1 | ||||||||
| DB_info | Database | AceView | gene | XD535 | |||||
| WormQTL | gene | WBGene00003776 | |||||||
| WormFlux | gene | WBGene00003776 | |||||||
| NDB | locus_tag | CELE_F52B10.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003776|UniProtKB=Q20641 | |||||||
| family | PTHR45615 | ||||||||
| NCBI | gene | 180581 | |||||||
| RefSeq | protein | NM_001374981.3 | |||||||
| NM_076103.6 | |||||||||
| TrEMBL | UniProtAcc | A0A5E4LXR0 | |||||||
| Q20641 | |||||||||
| UniProt_GCRP | UniProtAcc | Q20641 | |||||||
| OMIM | gene | 160745 | |||||||
| 160775 | |||||||||
| 608568 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nmy | ||||||||
| Allele (107) | |||||||||
| Legacy_information | [C.elegansII] NMK. Encodes predicted non-muscle myosin heavy chain. [CGC] | ||||||||
| [Newbern C] nmy for Non-Muscle Myosin. | |||||||||
| Strain | WBStrain00001168 | ||||||||
| WBStrain00008459 | |||||||||
| WBStrain00026590 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Ortholog (59) | |||||||||
| Paralog (21) | |||||||||
| Structured_description | Concise_description | nmy-1 encodes a class II non-muscle myosin heavy chain related to Drosophila zipper, which plays a role in several aspects of embryonic morphogenesis; in C. elegans, NMY-1 is required for embryonic elongation and establishment of normal body morphology; however, nmy-1 functions redundantly with another non-muscle myosin heavy chain gene, nmy-2, during elongation and establishment of normal body morphology; mutations in nmy-1 suppress the hypercontraction phenotype produced by mutations in mel-11, a myosin phosphatase that regulates actomyosin filament contraction; in addition, NMY-1 may partner with MLC-4, myosin light chain 4, during elongation; NMY-1 expression is detected during embryogenesis, particularly at the onset of elongation. | Paper_evidence | WBPaper00002905 | |||||
| WBPaper00005654 | |||||||||
| WBPaper00006149 | |||||||||
| WBPaper00013563 | |||||||||
| WBPaper00017143 | |||||||||
| WBPaper00019610 | |||||||||
| WBPaper00023409 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 11 Sep 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable actin filament binding activity and microfilament motor activity. Involved in several processes, including locomotion; nematode larval development; and regulation of embryonic cell shape. Located in adherens junction and contractile fiber. Expressed in head; hypodermis; and tail. Human ortholog(s) of this gene implicated in several diseases, including aortic aneurysm (multiple); auditory system disease (multiple); and blood platelet disease (multiple). Is an ortholog of human MYH11 (myosin heavy chain 11). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (14) | ||||||||
| Molecular_info | Corresponding_CDS | F52B10.1a | |||||||
| F52B10.1b | |||||||||
| Corresponding_transcript | F52B10.1a.1 | ||||||||
| F52B10.1b.1 | |||||||||
| Other_sequence (63) | |||||||||
| Associated_feature (17) | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Chronogram1544 | ||||||||
| Expr2738 | |||||||||
| Expr6132 | |||||||||
| Expr1031765 | |||||||||
| Expr1151740 | |||||||||
| Expr2014340 | |||||||||
| Expr2032581 | |||||||||
| Drives_construct | WBCnstr00002060 | ||||||||
| WBCnstr00035872 | |||||||||
| Construct_product | WBCnstr00035872 | ||||||||
| Antibody | WBAntibody00000686 | ||||||||
| Microarray_results (16) | |||||||||
| Expression_cluster (192) | |||||||||
| Interaction (150) | |||||||||
| Map_info | Map | X | Position | -12.6731 | Error | 0.002148 | |||
| Positive | Positive_clone | B0410 | Author_evidence | Newbern C | |||||
| F52B10 | Author_evidence | Newbern C | |||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Y76F7 | Author_evidence | Newbern C | |||||||
| Mapping_data | Multi_point | 5597 | |||||||
| Pseudo_map_position | |||||||||
| Reference (26) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
