| WBGene00003776 | SMap | S_parent | Sequence | F52B10 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | nmy-1 |
| | | Sequence_name | F52B10.1 |
| | | Molecular_name | F52B10.1a |
| | | | F52B10.1a.1 |
| | | | CE31177 |
| | | | F52B10.1b |
| | | | CE04618 |
| | | | F52B10.1b.1 |
| | | Other_name | CELE_F52B10.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | nmy-1 |
| | DB_info | Database | AceView | gene | XD535 |
| | | | WormQTL | gene | WBGene00003776 |
| | | | WormFlux | gene | WBGene00003776 |
| | | | NDB | locus_tag | CELE_F52B10.1 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00003776|UniProtKB=Q20641 |
| | | | | family | PTHR45615 |
| | | | NCBI | gene | 180581 |
| | | | RefSeq | protein | NM_001374981.3 |
| | | | | | NM_076103.6 |
| | | | TrEMBL | UniProtAcc | A0A5E4LXR0 |
| | | | | | Q20641 |
| | | | UniProt_GCRP | UniProtAcc | Q20641 |
| | | | OMIM | gene | 160745 |
| | | | | | 160775 |
| | | | | | 608568 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | nmy |
| | Allele (107) |
| | Legacy_information | [C.elegansII] NMK. Encodes predicted non-muscle myosin heavy chain. [CGC] |
| | | [Newbern C] nmy for Non-Muscle Myosin. |
| | Strain | WBStrain00001168 |
| | | WBStrain00008459 |
| | | WBStrain00026590 |
| | RNASeq_FPKM (74) |
| | GO_annotation (27) |
| | Ortholog (59) |
| | Paralog (21) |
| | Structured_description | Concise_description | nmy-1 encodes a class II non-muscle myosin heavy chain related to Drosophila zipper, which plays a role in several aspects of embryonic morphogenesis; in C. elegans, NMY-1 is required for embryonic elongation and establishment of normal body morphology; however, nmy-1 functions redundantly with another non-muscle myosin heavy chain gene, nmy-2, during elongation and establishment of normal body morphology; mutations in nmy-1 suppress the hypercontraction phenotype produced by mutations in mel-11, a myosin phosphatase that regulates actomyosin filament contraction; in addition, NMY-1 may partner with MLC-4, myosin light chain 4, during elongation; NMY-1 expression is detected during embryogenesis, particularly at the onset of elongation. | Paper_evidence | WBPaper00002905 |
| | | | | | WBPaper00005654 |
| | | | | | WBPaper00006149 |
| | | | | | WBPaper00013563 |
| | | | | | WBPaper00017143 |
| | | | | | WBPaper00019610 |
| | | | | | WBPaper00023409 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson324 |
| | | | | Date_last_updated | 11 Sep 2006 00:00:00 |
| | | Automated_description | Predicted to enable actin filament binding activity and microfilament motor activity. Involved in several processes, including locomotion; nematode larval development; and regulation of embryonic cell shape. Located in adherens junction and contractile fiber. Expressed in head; hypodermis; and tail. Human ortholog(s) of this gene implicated in several diseases, including aortic aneurysm (multiple); auditory system disease (multiple); and blood platelet disease (multiple). Is an ortholog of human MYH11 (myosin heavy chain 11). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model (14) |
| Molecular_info | Corresponding_CDS | F52B10.1a |
| | | F52B10.1b |
| | Corresponding_transcript | F52B10.1a.1 |
| | | F52B10.1b.1 |
| | Other_sequence (63) |
| | Associated_feature (17) |
| Experimental_info | RNAi_result (11) |
| | Expr_pattern | Chronogram1544 |
| | | Expr2738 |
| | | Expr6132 |
| | | Expr1031765 |
| | | Expr1151740 |
| | | Expr2014340 |
| | | Expr2032581 |
| | Drives_construct | WBCnstr00002060 |
| | | WBCnstr00035872 |
| | Construct_product | WBCnstr00035872 |
| | Antibody | WBAntibody00000686 |
| | Microarray_results (16) |
| | Expression_cluster | WBPaper00029047:atx-3_upregulated |
| | | WBPaper00029359_1280 |
| | | WBPaper00029359_1289 |
| | | WBPaper00029359_1304 |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1497 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1604 |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00032976:non_compensated_genes |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00037047:aging_accelerated_insoluble_protein |
| | | WBPaper00037047:insoluble_protein |
| | | WBPaper00037950:dopaminergic-neurons_embryo_enriched |
| | | WBPaper00037950:excretory-cell_larva_enriched |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00040134:nhr-49(RNAi)_regulated_protein |
| | | WBPaper00044037:eat-2_upregulated |
| | | WBPaper00044128:DietaryRestriction_upregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:rising_dev_expression |
| | | WBPaper00044746:aging_upregulated_Day5 |
| | | WBPaper00044746:aging_upregulated_HeatShock |
| | | WBPaper00044786:emr-1(gk119)_upregulated |
| | | WBPaper00045314:S.aureus-induced_hlh-30(tm1978) |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h |
| | | WBPaper00046509:htz-1(ok3099)_upregulated |
| | | WBPaper00046509:lin-35(n745)_upregulated |
| | | WBPaper00048611:MnCl2_downregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049134:hpk-1(pk1393)_upregulated |
| | | WBPaper00049159:Microwave_upregulated_adult |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00049920:Glucose-Diet_upregulated_N2 |
| | | WBPaper00049920:hyl-2(tm2031)_upregulated |
| | | WBPaper00050182:lmn-1(L535P)_upregulated |
| | | WBPaper00050686:glp-1(e2141)_upregulated |
| | | WBPaper00050698:DEP-1_interacting |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051310:LIN-41_interacting |
| | | WBPaper00051404:alg-1(gk214)_downregulated |
| | | WBPaper00051404:alg-2(ok304)_downregulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq |
| | | WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053814:15C_downregulated_PY79 |
| | | WBPaper00054410:set-26(tm2467)_downregulated |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055386:daf-2(e1370)_upregulated |
| | | WBPaper00055969:electromagnetic-field_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_20C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056167:ifo-1(kc2)_downregulated |
| | | WBPaper00056284:ints-5(RNAi)_upregulated |
| | | WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057068:ints-4(RNAi)_downregulated |
| | | WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium |
| | | WBPaper00057288:Cold_downregulated_protein |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059440:LAG-1_repressed_4hr-auxin |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059728:5ug_cholesterol_upregulated |
| | | WBPaper00059728:20ug_cholesterol_upregulated |
| | | WBPaper00059895:wounding_upregulated |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060084:cco-1(RNAi)_downregulated_lin-40(yth27) |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:pm6 |
| | | WBPaper00061340:Seam_cell |
| | | WBPaper00061340:T |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061527:mup-2-unc-87_284 |
| | | WBPaper00061651:Spermatheca_enriched |
| | | WBPaper00061818:ELKS-1_interacting |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064005:starvation_downregulated_N2_mRNA |
| | | WBPaper00064055:trl-1(cas1077)_upregulated_non-starved |
| | | WBPaper00064055:trl-1(cas1077)_upregulated_starved |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064201:SNA-1_interacting |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064727:daf-2(e1370)_upregulated |
| | | WBPaper00064735:bet-1(RNAi)_vs_N2_upregulated |
| | | WBPaper00064735:bet-1(uth41)_vs_N2_upregulated |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected |
| | | WBPaper00065258:anchor-cell_enriched |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065623:98 |
| | | WBPaper00065841:11_2 |
| | | WBPaper00065841:43_0 |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066085:hda-3(ok1991)_upregulated |
| | | WBPaper00066085:sin-3(syb2172)_upregulated |
| | | WBPaper00066232:ash-2(RNAi)_downregulated_WT |
| | | cgc4489_group_4 |
| | | WBPaper00025032:cluster_12 |
| | | WBPaper00025099:MA_specific |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026952:class_E |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00030985:Enterococcus_faecalis_upregulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00032165:A_to_C_transit_increased |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_1 |
| | | WBPaper00032948:FedUp |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036286:Pattern_I |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00038231:Cry5B_1.5-fold_upregulated |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00040963:TA300_up |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041906:I-3690_vs_OP50_3d |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00042258:DA1877_upregulated_GravidAdult |
| | | WBPaper00045015:nhr-25(RNAi)_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_downregulated |
| | | WBPaper00047070:N2_starvation_downregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:Cluster_C |
| | Interaction (150) |
| Map_info | Map | X | Position | -12.6731 | Error | 0.002148 |
| | Positive | Positive_clone | B0410 | Author_evidence | Newbern C |
| | | | F52B10 | Author_evidence | Newbern C |
| | | | | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | Y76F7 | Author_evidence | Newbern C |
| | Mapping_data | Multi_point | 5597 |
| | Pseudo_map_position |
| Reference (26) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
