| WBGene00003222 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | Y2H9A |
| Identity | Version | 1 |
| | Name | CGC_name | mes-4 | Person_evidence | WBPerson632 |
| | | Sequence_name | Y2H9A.1 |
| | | Molecular_name | Y2H9A.1 |
| | | | Y2H9A.1.1 |
| | | | CE27781 |
| | | Other_name | CELE_Y2H9A.1 | Accession_evidence | NDB | BX284605 |
| | | Public_name | mes-4 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | mes |
| | Allele (85) |
| | Legacy_information | [C.elegansII] bn50 : grandchildless, progeny undergo normal embryogenesis but develop into agametic adults(only 10 germ cells made). Normal P granule staining. XO germ line much less affected.OA3: bn23, bn58, bn67 (all similar). [Capowski et al. 1991; SS] |
| | Strain | WBStrain00022581 |
| | | WBStrain00034440 |
| | | WBStrain00036937 |
| | | WBStrain00029957 |
| | RNASeq_FPKM (74) |
| | GO_annotation (30) |
| | Ortholog (56) |
| | Paralog | WBGene00003040 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00016603 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00003220 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00004781 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00004782 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00008062 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00008206 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00008527 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00011729 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00012802 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00018023 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00019584 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00019690 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00019883 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00020006 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00020919 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00020920 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00021282 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00021515 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | mes-4 encodes a SET domain-containing protein that also contains three plant homeodomain (PHD) fingers; MES-4 is required maternally for normal germline development, but in contrast to MES-2, -3, and -6, does not appear to be required for somatic anteroposterior patterning; in germline development, MES-4 activity is essential for regulating active chromatin states and for excluding the MES-2/MES-3/MES-6 chromatin repression complex from the autosomes; MES-4 is also required for germline silencing of repetitive transgene arrays; MES-4 localizes to autosomes, and is detectable in the distal, mitotic region of the germline, in meiotic germ cells during late pachytene, and in oocytes; MES-4 is detected in all somatic and germline nuclei of the early embryo, but by the 100-cell stage, its expression becomes restricted to the primordial germ cells, Z2 and Z3; exclusion of MES-4 from X chromosomes requires the activity of the MES-2, -3, -6 complex. | Paper_evidence | WBPaper00002979 |
| | | | | | WBPaper00005301 |
| | | | | | WBPaper00005923 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 30 Jul 2004 00:00:00 |
| | | Automated_description | Enables histone H3K36 methyltransferase activity. Involved in germ-line sex determination and heterochromatin formation. Acts upstream of or within with a positive effect on dosage compensation by hypoactivation of X chromosome. Located in X chromosome; autosome; and nuclear chromosome. Part of chromatin. Expressed in Z2; Z3; and germ line. Human ortholog(s) of this gene implicated in several diseases, including Sotos syndrome 1; lung non-small cell carcinoma; and neuroblastoma. Is an ortholog of human NSD1 (nuclear receptor binding SET domain protein 1); NSD2 (nuclear receptor binding SET domain protein 2); and NSD3 (nuclear receptor binding SET domain protein 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0112103 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) |
| | | DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12766) |
| | | DOID:10907 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) |
| | | DOID:14748 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) |
| | | DOID:769 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) |
| | | DOID:8692 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12767) |
| | | DOID:9119 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14234) |
| Molecular_info | Corresponding_CDS | Y2H9A.1 |
| | Corresponding_CDS_history | Y2H9A.1:wp51 |
| | Corresponding_transcript | Y2H9A.1.1 |
| | Other_sequence | AF233290 |
| | | CBC09012_1 |
| | | CBC03017_1 |
| | | CRC01044_1 |
| | | CR09817 |
| | | CR07209 |
| | | CRC02608_1 |
| | Associated_feature (11) |
| | Gene_product_binds (4418) |
| | Transcription_factor | WBTranscriptionFactor000137 |
| Experimental_info | RNAi_result (41) |
| | Expr_pattern | Expr1905 |
| | | Expr4222 |
| | | Expr14367 |
| | | Expr1027992 |
| | | Expr1031522 |
| | | Expr1159295 |
| | | Expr1200052 |
| | | Expr2013532 |
| | | Expr2031766 |
| | Drives_construct | WBCnstr00036178 |
| | Construct_product | WBCnstr00036178 |
| | Regulate_expr_cluster | WBPaper00028483:Down_mes-4_vs_WT |
| | | WBPaper00028483:Up_mes-4_vs_WT |
| | | WBPaper00041688:mes-2_mes-4_downregulated |
| | | WBPaper00041688:mes-2_mes-4_upregulated |
| | | WBPaper00064315:mes-4(bn73)_downregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_downregulated_PGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_PGCs |
| | Antibody | WBAntibody00000524 |
| | | WBAntibody00001161 |
| | | WBAntibody00001162 |
| | | WBAntibody00001462 |
| | Microarray_results (18) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032425:up_in_lin-35 |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037682:sma-2_upregulated |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00038168:lin-15B(n744)_upregulated |
| | | WBPaper00038168:lin-35_upregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045050:drh-3 (ne4253)_downregulated |
| | | WBPaper00045420:fertilization_upregulated_protein |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046509:lin-35(n745)_upregulated |
| | | WBPaper00048690:hermaphrodite-Z1-Z4-daughter_enriched |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:daf-16(mu86)_downregulated_neuron |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050193:cec-4(ok3124)_downregulated_L1 |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050522:mafr-1(tm6082)_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:hypodermis_enriched |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:mes-4(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056290:hsp-6(mg585)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00057041:spc-1(cas971)_upregulated |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058691:set-2(bn129)_downregulated |
| | | WBPaper00058969:RIS_depleted |
| | | WBPaper00059027:neuron-synapses_enriched |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00061007:HB101_downregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061274:hypergravity_15xg_upregulated |
| | | WBPaper00061340:ADA_ADE_grandparent |
| | | WBPaper00061340:ASE_parent |
| | | WBPaper00061340:AVH_parent |
| | | WBPaper00061340:Ciliated_non_amphid_neuron |
| | | WBPaper00061340:Excretory_cell_parent |
| | | WBPaper00061340:I1_parent |
| | | WBPaper00061340:I2_grandparent |
| | | WBPaper00061340:Neuroblast_ASE_ASJ_AUA |
| | | WBPaper00061340:Neuroblast_IL1_IL2 |
| | | WBPaper00061340:OLQ_grandparent |
| | | WBPaper00061340:Parent_of_MI_pm1DR |
| | | WBPaper00061340:Pharyngeal_neuron |
| | | WBPaper00061340:RIA_parent |
| | | WBPaper00061527:pch-2-B0393.3 |
| | | WBPaper00061527:pcn-1-cyb-3_17196 |
| | | WBPaper00061699:daf-18(ok480)_upregulated |
| | | WBPaper00062056:lin-35(n745)_upregulated |
| | | WBPaper00062056:lin-36(we36)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064107:lin-35(n745)_upregulated |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064871:hypoxia_upregulated_F1 |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065149:lin-52(n771)_upregulated |
| | | WBPaper00065258:anchor-cell_depleted |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | WBPaper00065373:sek-1(km4)_upregulated_Ref |
| | | WBPaper00065841:1_0 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | cgc4489_group_2 |
| | | WBPaper00025032:cluster_148 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_B |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042574:N2_OrsayVirus_upregulated |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00047070:N2_starvation_downregulated |
| | | WBPaper00048637:lin-35(n745)_starvation_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | [cgc6390]:Cluster_F |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction (83) |
| Map_info | Map | V | Position | 5.34414 | Error | 0.004146 |
| | Well_ordered |
| | Positive | Positive_clone | Y2H9A | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | Y29H9A |
| | Mapping_data | 2_point | 6090 |
| | | | 6091 |
| | | | 6092 |
| | | | 6093 |
| | | | 6094 |
| | | | 6095 |
| | | | 6096 |
| | | | 6097 |
| | | | 6098 |
| | | Multi_point | 2157 |
| | | | 2158 |
| | | | 2159 |
| | | | 2160 |
| | | | 2161 |
| | | | 2162 |
| | | | 2163 |
| | | | 2164 |
| | | | 2165 |
| | | | 2166 |
| | | Pos_neg_data | 6685 |
| | | | 6686 |
| | | | 6687 |
| | Landmark_gene |
| Reference (120) |
| Remark | Sequence connection from [Strome S] |
| Method | Gene |
