WormBase Tree Display for Gene: WBGene00011729
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| WBGene00011729 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | set-16 | Person_evidence | WBPerson1730 | |||||
| WBPerson268 | |||||||||
| WBPerson632 | |||||||||
| Sequence_name | T12D8.1 | ||||||||
| Molecular_name | T12D8.1 | ||||||||
| T12D8.1.1 | |||||||||
| CE44315 | |||||||||
| Other_name | tag-350 | Person_evidence | WBPerson201 | ||||||
| CELE_T12D8.1 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | set-16 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:52 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 03 May 2007 10:33:07 | WBPerson2970 | Name_change | CGC_name | set-16 | ||||
| Other_name | tag-350 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | set | ||||||||
| Allele (187) | |||||||||
| Strain | WBStrain00027470 | ||||||||
| WBStrain00036268 | |||||||||
| WBStrain00036332 | |||||||||
| WBStrain00037730 | |||||||||
| WBStrain00033873 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Ortholog (49) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Concise_description | set-16 encodes an H3K methyltransferases of the SET1/mixed lineage leukaemia (MLL) family; SET-16 regulates levels of H3K4 trimethylation in vivo and the SET-16 SET domain has H3K4 monomethylase activity in vitro; set-16 is an essential gene and also plays a role in attenuating Ras-mediated signaling during vulval development, by regulating expression of ajm-1, which encodes a component of cellular junctions; a set-16::GFP reporter fusion is expressed at high levels in the non-vulval descendants of the vulval precursor cells and at lower levels in the vulval cells themselves. | Paper_evidence | WBPaper00030864 | |||||
| WBPaper00035979 | |||||||||
| WBPaper00036383 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 21 Sep 2010 00:00:00 | ||||||||
| Automated_description | Enables histone H3K4 methyltransferase activity. Involved in programmed cell death and regulation of vulval development. Part of MLL3/4 complex. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P8.p hermaphrodite; and linker cell. Human ortholog(s) of this gene implicated in several diseases, including Kabuki syndrome; Kleefstra syndrome 2; and carcinoma (multiple). Is an ortholog of human KMT2D (lysine methyltransferase 2D). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (24) | ||||||||
| Molecular_info | Corresponding_CDS | T12D8.1 | |||||||
| Corresponding_CDS_history | T12D8.1:wp189 | ||||||||
| T12D8.1:wp209 | |||||||||
| Corresponding_transcript | T12D8.1.1 | ||||||||
| Other_sequence (27) | |||||||||
| Associated_feature (21) | |||||||||
| Transcription_factor | WBTranscriptionFactor000787 | ||||||||
| Experimental_info | RNAi_result (45) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00003187 | ||||||||
| WBCnstr00005991 | |||||||||
| WBCnstr00012809 | |||||||||
| WBCnstr00030435 | |||||||||
| WBCnstr00038155 | |||||||||
| Construct_product | WBCnstr00030435 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (146) | |||||||||
| Interaction (85) | |||||||||
| Map_info | Map | III | Position | 21.3268 | Error | 0.002729 | |||
| Positive | Positive_clone | T12D8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5295 | |||||||
| 4243 | |||||||||
| 5609 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (23) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
