WormBase Tree Display for Gene: WBGene00016603
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| WBGene00016603 | SMap | S_parent | Sequence | C43E11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | met-1 | Person_evidence | WBPerson1730 | |||||
| WBPerson268 | |||||||||
| Sequence_name | C43E11.3 | ||||||||
| Molecular_name | C43E11.3a | ||||||||
| C43E11.3a.1 | |||||||||
| CE30503 | |||||||||
| C43E11.3b | |||||||||
| CE08681 | |||||||||
| C43E11.3b.1 | |||||||||
| C43E11.3b.2 | |||||||||
| C43E11.3b.3 | |||||||||
| Other_name | CELE_C43E11.3 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | met-1 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00016603 | |||||
| WormFlux | gene | WBGene00016603 | |||||||
| NDB | locus_tag | CELE_C43E11.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00016603|UniProtKB=A4LBC2 | |||||||
| family | PTHR22884 | ||||||||
| NCBI | gene | 172026 | |||||||
| RefSeq | protein | NM_058939.6 | |||||||
| NM_182042.4 | |||||||||
| TREEFAM | TREEFAM_ID | TF352219 | |||||||
| TrEMBL | UniProtAcc | A4LBC3 | |||||||
| A4LBC2 | |||||||||
| UniProt_GCRP | UniProtAcc | A4LBC2 | |||||||
| OMIM | gene | 612778 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:57 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 23 Mar 2007 15:51:10 | WBPerson1849 | Event | Acquires_merge | WBGene00044017 | ||||
| Acquires_merge | WBGene00044017 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | met | ||||||||
| Allele (162) | |||||||||
| Strain | WBStrain00036305 | ||||||||
| WBStrain00027452 | |||||||||
| WBStrain00027568 | |||||||||
| WBStrain00036778 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Contained_in_operon | CEOP1168 | ||||||||
| Ortholog (100) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Concise_description | met-1 encodes a histone methyltransferase whose SET domain is similar to that of Saccharomyces cerevisiae Set2p; loss of met-1 activity in the background of a mutant class A synMuv gene, such as lin-15A, results in a multivulval phenotype, indicating that met-1 acts to negatively regulate vulval cell fate specification; as met-1 is required for normal levels of histone H3K36 and H3K9 trimethylation and met-1;lin-15A animals show an increase in lin-3 EGF expression, met-1 likely acts as part of a transcriptional repressor complex that negatively regulates lin-3 EGF transcription to restrict vulval development to three of the six cells in the vulval equivalence group; in addition, genetic studies indicate that met-1 likely acts redundantly with met-2 to inhibit vulval cell fates. | Paper_evidence | WBPaper00030864 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 01 Apr 2008 00:00:00 | ||||||||
| Automated_description | Enables histone H3K36 methyltransferase activity. Involved in negative regulation of transcription by RNA polymerase II and negative regulation of vulval development. Predicted to be located in nucleus. Predicted to be part of chromatin. Expressed in hypodermis; intestine; and muscle cell. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); gastrointestinal system cancer (multiple); and idiopathic pulmonary fibrosis. Is an ortholog of human SETD2 (SET domain containing 2, histone lysine methyltransferase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060307 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18420) | ||||
| DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18420) | ||||||
| DOID:4467 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18420) | ||||||
| DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18420) | ||||||
| DOID:9253 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18420) | ||||||
| DOID:0050156 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18420) | ||||||
| DOID:3910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18420) | ||||||
| DOID:7474 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18420) | ||||||
| DOID:3571 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18420) | ||||||
| DOID:1790 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18420) | ||||||
| Molecular_info | Corresponding_CDS | C43E11.3a | |||||||
| C43E11.3b | |||||||||
| Corresponding_CDS_history | C43E11.3:wp173 | ||||||||
| C43E11.3a:wp136 | |||||||||
| C43E11.3b:wp90 | |||||||||
| C43E11.3b:wp136 | |||||||||
| Corresponding_transcript | C43E11.3a.1 | ||||||||
| C43E11.3b.1 | |||||||||
| C43E11.3b.2 | |||||||||
| C43E11.3b.3 | |||||||||
| Other_sequence | CR05423 | ||||||||
| MH05940 | |||||||||
| CRC07104_1 | |||||||||
| CRC07781_1 | |||||||||
| Associated_feature (14) | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Expr14350 | ||||||||
| Expr1016667 | |||||||||
| Expr1037129 | |||||||||
| Expr1146371 | |||||||||
| Expr2013535 | |||||||||
| Expr2031769 | |||||||||
| Drives_construct | WBCnstr00027945 | ||||||||
| Construct_product | WBCnstr00027945 | ||||||||
| Regulate_expr_cluster | WBPaper00064315:met-1(bn200)_downregulated_PGCs | ||||||||
| WBPaper00064315:met-1(bn200)_upregulated_PGCs | |||||||||
| Antibody | WBAntibody00002850 | ||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (131) | |||||||||
| Interaction (39) | |||||||||
| Map_info | Map | I | Position | -1.53098 | Error | 0.003143 | |||
| Positive | Positive_clone | C43E11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5329 | |||||||
| 4507 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (30) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
