WormBase Tree Display for Gene: WBGene00016603

WBGene00016603 SMap: S_parent: Sequence: C43E11
  Identity: Version: 2
    Name: CGC_name: met-1 Person_evidence: WBPerson1730
            WBPerson268
      Sequence_name: C43E11.3
      Molecular_name: C43E11.3a
        C43E11.3a.1
        CE30503
        C43E11.3b
        CE08681
        C43E11.3b.1
        C43E11.3b.2
        C43E11.3b.3
      Other_name: CELE_C43E11.3 Accession_evidence: NDB BX284601
      Public_name: met-1
    DB_info: Database: WormQTL gene WBGene00016603
        WormFlux gene WBGene00016603
        NDB locus_tag CELE_C43E11.3
        Panther gene CAEEL|WormBase=WBGene00016603|UniProtKB=A4LBC2
          family PTHR22884
        NCBI gene 172026
        RefSeq protein NM_058939.6
            NM_182042.4
        TREEFAM TREEFAM_ID TF352219
        TrEMBL UniProtAcc A4LBC3
            A4LBC2
        UniProt_GCRP UniProtAcc A4LBC2
        OMIM gene 612778
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:57 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 23 Mar 2007 15:51:10 WBPerson1849 Event: Acquires_merge: WBGene00044017
      Acquires_merge: WBGene00044017
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: met
    Allele (162)
    Strain: WBStrain00036305
      WBStrain00027452
      WBStrain00027568
      WBStrain00036778
    RNASeq_FPKM (74)
    GO_annotation (19)
    Contained_in_operon: CEOP1168
    Ortholog: WBGene00033170 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            Inparanoid_8
      WBGene00160599 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
      WBGene00062392 Caenorhabditis remanei From_analysis: TreeFam
            Inparanoid_8
      WBGene00153489 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00162566 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00141579 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00145193 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00194473 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00156683 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00142923 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00147168 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00155482 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00142524 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00153750 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00156892 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00141349 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00154782 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00184572 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00123699 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00069493 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00061549 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00066924 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00066923 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00062311 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00063295 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00065102 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00060735 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00094649 Pristionchus pacificus From_analysis: Inparanoid_8
      WBGene00191067 Caenorhabditis brenneri From_analysis: WormBase-Compara
      WBGene00023621 Caenorhabditis briggsae From_analysis: WormBase-Compara
      WBGene00027903 Caenorhabditis briggsae From_analysis: WormBase-Compara
      WBGene00034486 Caenorhabditis briggsae From_analysis: WormBase-Compara
      WBGene00034487 Caenorhabditis briggsae From_analysis: WormBase-Compara
      WBGene00036618 Caenorhabditis briggsae From_analysis: WormBase-Compara
      WBGene00036619 Caenorhabditis briggsae From_analysis: WormBase-Compara
      WBGene00226014 Brugia malayi From_analysis: WormBase-Compara
      WBGene00226798 Brugia malayi From_analysis: WormBase-Compara
      WBGene00230701 Brugia malayi From_analysis: WormBase-Compara
      CSP26.g13377 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP26.g20816 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP26.g5162 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP26.g6800 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP26.g8798 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP31.g9174 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP31.g9176 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g12089 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g15262 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP38.g9723 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP40.g11127 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g11128 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g11133 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g12232 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g12368 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g15313 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g15690 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g16239 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g19966 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g19967 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g20554 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g20852 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g22103 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g24669 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g8251 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cnig_chr_IV.g12157 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Cnig_chr_IV.g12296 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Cnig_chr_IV.g12297 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Cnig_chr_IV.g13540 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Cnig_chr_X.g24856 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Cnig_chr_X.g24857 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Cnig_chr_X.g24858 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp5_scaffold_02870.g28197 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_00115 Caenorhabditis latens From_analysis: WormBase-Compara
      FL83_00116 Caenorhabditis latens From_analysis: WormBase-Compara
      FL83_00117 Caenorhabditis latens From_analysis: WormBase-Compara
      FL83_00118 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_024834 Caenorhabditis remanei From_analysis: WormBase-Compara
      GCK72_024836 Caenorhabditis remanei From_analysis: WormBase-Compara
      GCK72_024837 Caenorhabditis remanei From_analysis: WormBase-Compara
      Sp34_10349400 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrI_pilon.g677 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00182724 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00218395 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00051270 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00051271 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00051272 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00051273 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00051274 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00066438 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00238265 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00246807 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00291387 Trichuris muris From_analysis: WormBase-Compara
      WBGene00296004 Trichuris muris From_analysis: WormBase-Compara
      WBGene00302914 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000003704 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
      FB:FBgn0030486 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
      ZFIN:ZDB-GENE-030131-6101 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
      ZFIN:ZDB-GENE-030131-2140 Danio rerio From_analysis: OrthoFinder
            OrthoInspector
      HGNC:18420 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
      MGI:1918177 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
      RGD:1305576 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
    Paralog (19)
    Structured_description: Concise_description: met-1 encodes a histone methyltransferase whose SET domain is similar to that of Saccharomyces cerevisiae Set2p; loss of met-1 activity in the background of a mutant class A synMuv gene, such as lin-15A, results in a multivulval phenotype, indicating that met-1 acts to negatively regulate vulval cell fate specification; as met-1 is required for normal levels of histone H3K36 and H3K9 trimethylation and met-1;lin-15A animals show an increase in lin-3 EGF expression, met-1 likely acts as part of a transcriptional repressor complex that negatively regulates lin-3 EGF transcription to restrict vulval development to three of the six cells in the vulval equivalence group; in addition, genetic studies indicate that met-1 likely acts redundantly with met-2 to inhibit vulval cell fates. Paper_evidence: WBPaper00030864
          Curator_confirmed: WBPerson1843
            WBPerson1823
            WBPerson567
          Date_last_updated: 01 Apr 2008 00:00:00
      Automated_description: Enables histone H3K36 methyltransferase activity. Involved in negative regulation of transcription by RNA polymerase II and negative regulation of vulval development. Predicted to be located in nucleus. Predicted to be part of chromatin. Expressed in hypodermis; intestine; and muscle cell. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); gastrointestinal system cancer (multiple); and idiopathic pulmonary fibrosis. Is an ortholog of human SETD2 (SET domain containing 2, histone lysine methyltransferase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0060307 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18420)
      DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18420)
      DOID:4467 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18420)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18420)
      DOID:9253 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18420)
      DOID:0050156 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18420)
      DOID:3910 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18420)
      DOID:7474 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18420)
      DOID:3571 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18420)
      DOID:1790 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18420)
  Molecular_info: Corresponding_CDS: C43E11.3a
      C43E11.3b
    Corresponding_CDS_history: C43E11.3:wp173
      C43E11.3a:wp136
      C43E11.3b:wp90
      C43E11.3b:wp136
    Corresponding_transcript: C43E11.3a.1
      C43E11.3b.1
      C43E11.3b.2
      C43E11.3b.3
    Other_sequence: CR05423
      MH05940
      CRC07104_1
      CRC07781_1
    Associated_feature (14)
  Experimental_info: RNAi_result (12)
    Expr_pattern: Expr14350
      Expr1016667
      Expr1037129
      Expr1146371
      Expr2013535
      Expr2031769
    Drives_construct: WBCnstr00027945
    Construct_product: WBCnstr00027945
    Regulate_expr_cluster: WBPaper00064315:met-1(bn200)_downregulated_PGCs
      WBPaper00064315:met-1(bn200)_upregulated_PGCs
    Antibody: WBAntibody00002850
    Microarray_results (28)
    Expression_cluster (131)
    Interaction (39)
  Map_info: Map: I Position: -1.53098 Error: 0.003143
    Positive: Positive_clone: C43E11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5329
        4507
    Pseudo_map_position
  Reference (30)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene