WormBase Tree Display for Gene: WBGene00003220
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| WBGene00003220 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mes-2 | Person_evidence | WBPerson632 | |||||
| Sequence_name | R06A4.7 | ||||||||
| Molecular_name | R06A4.7 | ||||||||
| R06A4.7.1 | |||||||||
| CE28067 | |||||||||
| Other_name | CELE_R06A4.7 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | mes-2 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mes | ||||||||
| Allele (84) | |||||||||
| Legacy_information | [C.elegansII] bn11 : grandchildless, progeny undergo normal embryogenesis but develop into agametic adults;few germ cells made. XO germ line less affected. Normal P granule staining. OA2: bn27, bn48. Cloned: 2.5 kb transcript, encodes SET domain protein, closest similarity to Drosophila Enhancer of zeste. [Capowski et al. 1991; SS] | ||||||||
| Strain | WBStrain00034436 | ||||||||
| WBStrain00037311 | |||||||||
| WBStrain00030108 | |||||||||
| WBStrain00022450 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Ortholog (31) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Concise_description | mes-2 encodes a SET domain-containing protein that is orthologous to the Drosophila Polycomb group protein Enhancer of zeste [E(Z)]; as a member of a Polycomb-like chromatin repressive complex with MES-3 and MES-6, MES-2 is required maternally for normal germline development and during larval development, for anteroposterior patterning; during germline development, the MES-2/MES-3/MES-6 complex is believed to be essential for maintaining repression of the X chromosome, and in transgenic animals, the complex is necessary for germline repression of repetitive transgenes; in axial patterning, the MES-2/MES-3/MES-6 complex is required in somatic tissues for maintaining homeotic gene repression, acting upstream of the Hox genes lin-39, mab-5, and egl-5, as well as the egl-5 target gene lin-32; in addition, MES-2 activity is required for normal levels and localization of MES-3 in >24-cell-stage embryos; MES-2 expression is detected in the primordial germ cells and germline nuclei throughout development, in all nuclei in early embryos, and in somatic nuclei, including those of the male tail, in L2 and L3 larvae; in the nucleus, MES-2 appears to localize to chromatin. | Paper_evidence | WBPaper00001477 | |||||
| WBPaper00003144 | |||||||||
| WBPaper00004657 | |||||||||
| WBPaper00005019 | |||||||||
| WBPaper00005301 | |||||||||
| WBPaper00005923 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 14 Mar 2006 00:00:00 | ||||||||
| Automated_description | Enables histone H3K27 methyltransferase activity. Involved in epigenetic regulation of gene expression; germ-line stem cell division; and tissue development. Part of PcG protein complex and nucleosome. Expressed in Z2; Z3; germ line; hypodermis; and intestine. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); and respiratory system cancer (multiple). Is an ortholog of human EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit) and EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (32) | ||||||||
| Molecular_info | Corresponding_CDS | R06A4.7 | |||||||
| Corresponding_CDS_history | R06A4.7:wp52 | ||||||||
| Corresponding_transcript | R06A4.7.1 | ||||||||
| Other_sequence | AF011893 | ||||||||
| SRC07064_1 | |||||||||
| FC813517.1 | |||||||||
| CRC00437_1 | |||||||||
| JI459720.1 | |||||||||
| JI469763.1 | |||||||||
| FC813514.1 | |||||||||
| CR00887 | |||||||||
| CBC09282_1 | |||||||||
| Associated_feature | WBsf644846 | ||||||||
| WBsf658401 | |||||||||
| WBsf990695 | |||||||||
| WBsf222455 | |||||||||
| WBsf222456 | |||||||||
| WBsf222457 | |||||||||
| Transcription_factor | WBTranscriptionFactor000613 | ||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern | Expr1414 | ||||||||
| Expr1415 | |||||||||
| Expr14366 | |||||||||
| Expr1021565 | |||||||||
| Expr1031520 | |||||||||
| Expr1155052 | |||||||||
| Expr1200358 | |||||||||
| Expr2013530 | |||||||||
| Expr2031764 | |||||||||
| Drives_construct | WBCnstr00036180 | ||||||||
| Construct_product | WBCnstr00036180 | ||||||||
| Regulate_expr_cluster | WBPaper00041688:mes-2_mes-4_downregulated | ||||||||
| WBPaper00041688:mes-2_mes-4_upregulated | |||||||||
| WBPaper00050094:mes-2(bn11)_downregulated | |||||||||
| WBPaper00050094:mes-2(bn11)_upregulated | |||||||||
| Antibody | WBAntibody00000184 | ||||||||
| WBAntibody00000738 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (121) | |||||||||
| Interaction (122) | |||||||||
| WBProcess | WBbiopr:00000135 | ||||||||
| Map_info | Map | II | Position | 22.9598 | Error | 0.005825 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | R06A4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 6099 | |||||||
| 6100 | |||||||||
| 6101 | |||||||||
| 6102 | |||||||||
| Multi_point | 2167 | ||||||||
| 5437 | |||||||||
| Reference (109) | |||||||||
| Method | Gene |
